1. Sato, S., Suzuki, S., Naiki-Ito, A., Komiya, M., Long, N., Kato, H., Sagawa, H., Yamashita, Y., Shirai, T., Takahashi, S.: Establishment of an invasive prostate cancer model in transgenic rats by intermittent testosterone administration. J Toxicol Pathol, 27: 43-49, 2014.

2. Okamoto, Y., Shinjo, K., Shimizu, Y., Sano, T., Yamao, K., Gao, W., Fujii, M., Osada, H., Sekido, Y., Murakami, S., Tanaka, Y., Joh, T., Sato, S., Takahashi, S., Wakita, T., Zhu, J., Issa, J-PJ., Kondo, Y.: Hepatitis virus infection affects DNA methylation in mice with humanized livers. Gastroenterology, 146: 562-572, 2014.

3. Chew, SH., Okazaki, Y., Nagai, H., Misawa, N., Akatsuka, S., Yamashita, K., Jiang, L., Yamashita, Y., Noguchi, M., Hosoda, K., Sekido, Y., Takahashi, T., Toyokuni, S.: Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production. Carcinogenesis, 35: 164-172, 2014.

4. Kawakubo, T., Yasukochi, A., Toyama, T., Takahashi, S., Okamoto, K., Tsukuba, T., Nakamura, S., Ozaki, Y., Nishigaki, K., Yamashita, H., Yamamoto, K.: Repression of cathepsin E increases the risk of mammary carcinogenesis and links to poor prognosis in breast cancer patients. Carcinogenesis, 35: 714-726, 2014.

5. Nakasuka, K., Ito, S., Miyata, K., Inomata, M., Yoshida, T., Tamai, N., Suzuki, S., Murakami, Y., Sato, K., Suzuki, S., Eishi, Y., Morimoto, S.: A case of idiopathic giant cell myocarditis with a past history of sarcoidosis. J Card Cases, 9: 35-39, 2014.

6. Kimura, Y., Sato, S., Hitomi, E., Ohyama, M., Adachi, K., Inagaki, Y., Yamakawa, Y., Hirano, A., Kawai, H., Tsuchida, K., Senoo, K., Katsumi, K., Joh, T.: Coexpression of organic anion-transporting polypeptides 1B3 and multidrug-resistant protein 2 increases the enhancement effects of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid on hepatocellular carcinoma in magnetic resonance imaging. Hepatol Res, 44: 327-337, 2014.

7. Dodmane, PR., Arnold, LL., Muirhead, DE., Suzuki, S., Yokohira, M., Pennington, KL., Dave, BJ., Lu, X., Le, XC., Cohen, SM.: Characterization of intracellular inclusions in the urothelium of mice exposed to inorganic arsenic. Toxicol Sci, 137: 36-46, 2014.

8. Shimura, T., Ebi, M., Yamada, T., Hirata, Y., Nishiwaki, H., Mizushima, T., Asukai, K., Togawa, S., Takahashi, S., Joh, T.: Multicenter, prospective, comparative trial of magnifying chromoendoscopy and endoscopic ultrasonography to predict invasion depth of early colorectal cancer. Clin Gastroenterol Hepatol, 12: 662-668, 2014.

9. Fujii, K., Yamashita, Y., Yamamoto, T., Takahashi, K., Hashimoto, K., Miyata, T., Kawai, K., Kikkawa, F., Toyokuni, S., Nagasaka, T. Ovarian mucinous tumors arising from mature cystic teratomas. A molecular genetic approach for understanding the cellular origin. Hum Pathol, 45: 717-724, 2014.

10. Tsujiuchi, T., Natsume, A., Motomura, K., Kondo, G., Ranjit, M., Hachisu, R., Sugimura, I., Tomita, S., Takehara, I., Woolley, M., Barua, NU., Gill, SS., Bienemann, AS., Yamashita, Y., Toyokuni, S., Wakabayashi, T.: Preclinical evaluation of an O6-methylguanine-DNA methyltransferase-siRNA/liposome complex administered by convection-enhanced delivery to rat and porcine brains. Am J Transl Res, 6: 169-178, 2014.

11. Miyabe, K., Notohara, K., Nakazawa, T., Hayashi, K., Naitoh, I., Okumura, F., Shimizu, S., Yoshida, M., Yamashita, H., Takahashi, S., Ohara, H., Joh, T.: Histological evaluation of obliterative phlebitis for the diagnosis of autoimmune pancreatitis. J Gastroenterol, 49: 715-726, 2014.

12. Oseto, K., Suzumori, N., Nishikawa, R., Nishikawa, H., Arakawa, A., Ozaki, Y., Asai, H., Kawai, M., Mizuno, K., Takahashi, S., Shirai, T., Yamada-Namikawa, C., Nakanishi, M., Kajiyama, H., Kikkawa, F., Sugiura-Ogasawara, M.: Mutational analysis of FOXL2 p.C134W and expression of bone morphogenetic protein 2 in Japanese patients with granulosa cell tumor of ovary. J Obst Gynecol Res, 40: 1197-1204, 2014.

13. Shinjo, K., Yamashita, Y., Yamamoto, E., Akatsuka, S., Uno, N., Kamiya, A., Niimi, K., Sakaguchi, Y., Nagasaka, T., Takahashi, T., Shibata, K., Kajiyama, H., Kikkawa, F., Toyokuni, S.: Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. Int J Cancer, 135: 308-318, 2014.

14. Oomura, M., Sakakibara, N., Suzuki, S., Wakita, A., Mori, Y., Kamimoto, K.: Intravascular lymphomatosis mimicking primary central nervous system lymphoma: A case report and literature review. Case Rep Neurol, 6: 101-108, 2014.

15. Kuno, T., Hata, K., Takamatsu, M., Hara, A., Hirose, Y., Takahashi, S., Imaida, K., Tanaka, T.: The peroxisome proliferator-activated receptor (PPAR) α agonist fenofibrate suppresses chemically induced lung alveolar proliferative lesions in male obese hyperlipidemic mice. Int J Mol Sci, 15: 9160-9172, 2014.

16. Arnold, LL., Suzuki, S., Yokohira, M., Kakiuchi-Kiyota, S., Pennington, KL., Cohen SM.: Time course of urothelial changes in rats and mice orally administered arsenite. Toxicol Pathol, 42: 855-862, 2014.

17. Yamashita, Y., Ito, Y., Isomura, H., Takemura, N., Okamoto, A., Motomura, K., Tsujiuchi, T., Natsume, A., Wakabayashi, T., Toyokuni, S., Tsurumi, T.: Lack of presence of the human cytomegalovirus in human glioblastoma. Mod Pathol, 27: 922-929, 2014.

18. Yamashita, H., Naitoh, I., Nakazawa, T., Hayashi, K., Miyabe, K., Shimizu, S., Kondo, H., Yoshida, M., Umemura, S., Hori, Y., Ohara, H., Takahashi, S., Joh, T.: A comparison of the diagnostic efficacy in type 1 autoimmune pancreatitis based on biopsy specimens from various organs. Pancreatology, 14: 186-192, 2014.

19. Endo, Y., Yu, D., Yoshimoto, N., Asano, T., Hato, Y., Yamashita, H., Sato, S., Takahashi, S., Fujii, Y., Toyama, T.: HER2 mutation status in Japanese HER2-negative breast cancer patients. Jpn J Clin Oncol, 44: 619-623, 2014.

20. Johmura, Y., Shimada, M., Misaki, T., Naiki-Ito, A., Miyoshi, H., Motoyama, N., Ohtani, N., Hara, E., Nakamura, M., Morita, A., Takahashi, S., Nakanishi, M.: Necessary and sufficient role for a mitosis skip in senescence induction. Mol Cell, 55: 73-84, 2014.

21. Jiang, L., Yamashita, Y., Chew, SH, Akatsuka, S., Ukai, S., Wang, S., Nagai, H., Okazaki, Y., Takahashi, T., Toyokuni, S.: Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma. J Pathol, 233: 402-414, 2014.

22. Naiki, T., Naiki-Ito, A., Asamoto, M., Kawai, N., Tozawa, K., Etani, T., Sato, S., Suzuki, S., Shirai, T., Kohri, K., Takahashi, S.: GPX2 overexpression is involved in cell proliferation and prognosis of castration-resistant prostate cancer. Carcinogenesis, 35: 1962-1967, 2014.

23. Hachiya, K., Wakami, K., Tani, T., Yoshida, A., Suzuki, S., Suda, H., Ohte, N.: Double-valve replacement for mitral and aortic regurgitation in a patient with Libman-Sacks endocarditis. Intern Med, 53: 1769-1773, 2014.

24. Arima, H., Hirate, H., Sugiura, T., Suzuki, S., Takahashi, S., Sobue, K.: IV injection of polystyrene beads for mouse model of sepsis causes severe glomerular injury. J Intensive Care, 2: 21, 2014.

25. Shirai, T., Imai, N., Wang, J., Takahashi, S., Kawabe, M., Wake, K., Kawai, H., Watanabe, S., Furukawa, F., Fujiwara, O.: Multigenerational effects of whole body exposure to 2.14 GHz W-CDMA cellular phone signals on brain function in rats. Bioelectromagnetics,
35: 497-511, 2014.

26. Tozawa, K., Yasui, T., Umemoto, Y., Mizuno, K., Okada, A., Kawai, N., Takahashi, S., Kohri, K.: The pitfalls of robot-assisted radical prostatectomy: A comparison of positive surgical margins between robotic and laparoscopic surgery. Int J Urol, 21: 976-979, 2014.

27. Hayashi, Y., Sasaki, H., Takeshita, S., Nishikawa, R., Nishikawa, H., Arakawa, A., Yamashita, Y., Takahashi, S., Sugiura-Ogasawara, M.: Usefulness of immunohistochemistry for detection of the BRAF V600E mutation in serous ovarian tumors. Oncol Rep, 32:1815-1819, 2014.

28. Asano, T., Sato, S., Yoshimoto, N., Endo, Y., Hato, Y., Yu, D., Takahashi, S., Fujii, Y., Toyama, T.: High expression of LMTK3 is an independent factor indicating a poor prognosis in Japanese estrogen receptor α-positive breast cancer patients. Jpn J Clin Oncol, 44: 889-897, 2014.

29. Punfa, W., Suzuki, S., Pitchakarn, P., Yodkeeree, S., Naiki, T., Takahashi, S., Limtrakul, P.: Curcumin-loaded PLGA nanoparticles conjugated with anti-P-glycoprotein antibody to overcome multidrug resistance. Asian Pac J Cancer Prev, 15: 9249-9258, 2014.

30. Katano, H., Yamada, K., Sakurai, K., Takahashi, S.: Depiction of the vasa vasorum during carotid endarterectomy by intraoperative videoangiography. J Stroke Cerebrovasc Dis, 23: 2920-2927, 2014.

31. Endo, Y., Yamashita, H., Takahashi S., Sato, S., Yoshimoto, N., Asano, T., Hato, Y., Dong, Y., Fujii, Y., Toyama, T.: Immunohistochemical determination of the miR-1290 target arylamine N-acetyltransferase 1 (NAT1) as a prognostic biomarker in breast cancer. BMC Cancer, 14: 990, 2014.

32. Goshima, T., Sato, S., Haruta, M., Murata, K., Takahashi, S., Chiba, Y., Sharif, J., Koseki, H., Nakanishi, M., Shimada, M.: Predominant expression of MPP8 in spermatocytes and its implication for regulation of spermatogenesis. Nagoya Med J, 54: 51-60, 2014.

1. Suzuki, S., Shiraga, K., Sato, S., Punfa, W., Naiki-Ito, A., Yamashita, Y., Shirai, T., Takahashi, S.: Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis. Cancer Sci, 104: 1711-1717, 2013.

2. Suzuki, S., Pitchakarn, P., Sato, S., Shirai, T., Takahashi, S.: Apocynin, an NADPH oxidase inhibitor, suppresses progression of prostate cancer via Rac1 dephosphorylation. Exp Toxicol Pathol, 65: 1035-1041, 2013.

3. Osada, S., Suzuki, S., Yoshimi, C., Matsumoto, M., Shirai, T., Takahashi, S., Imagawa, M.: Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis. Oncol Rep, 30: 1669-1674, 2013.

4. Suzuki, S., Pitchakarn, P., Ogawa, K., Naiki-Ito, A., Chewonarin, T., Punfa, W., Asamoto, M., Shirai, T., Takahashi, S.: Expression of glutathione peroxidase 2 is associated with not only early hepatocarcinogenesis but also late stage metastasis. Toxicology, 311: 115-123, 2013.

5. Tokuda, N., Numata, S., Li, XJ., Nomura, T., Takizawa, M., Kondo, Y., Yamashita, Y., Hashimoto, N., Kiyono, T., Urano, T., Furukawa, K., Furukawa K.: β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5. Glycobiology, 10: 1175-1183, 2013.

6. Natsume, A., Ito, M., Katsushima, K., Ohka, F., Hatanaka, A., Shinjo, K., Sato, S., Takahashi, S., Ishikawa, Y., Takeuchi, I., Shimogawa, H., Uesugi, M., Okano, H., Kim, S.U., Wakabayashi, T., Issa, JP., Sekido, Y., Kondo, Y.: Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res, 73: 4559-4570, 2013.

7. Endo, Y., Sugiura, H., Yamashita, H., Takahashi, S., Yoshimoto, N., Iwasa, M., Asano, T., Toyama, T.: Myoepithelial carcinoma of the breast treated with surgery and chemotherapy. Case Rep Oncol Med, 2013: 164761, 2013.

8. Ogawa, K., Murasaki, T., Sugiura, S., Nakanishi, M., Shirai, T.: Organ differences in the impact of p27 (kip1) deficiency on carcinogenesis induced by N-methyl-N-nitrosourea. J Appl Toxcol, 33: 471-479, 2013.

9. Long, N., Suzuki, S., Sato, S., Naiki-Ito, A., Sakatani, K., Shirai, T., Takahashi, S.: Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways. Cancer Sci, 104: 298-303, 2013.

10. Endo, Y., Toyama, T., Takahashi, S., Yoshimoto, N., Iwasa, M., Asano, T., Fujii, Y., Yamashita, H.: MiR-1290 and its potential targets are associated with characteristics of estrogen receptor a-positive breast cancer. Endocr Relat Cancer, 20: 91-102, 2013.

11. Yasui, T., Tozawa, K., Kurosawa, S., Umemoto, Y., Okada, A., Mizuno, K., Kubota, Y., Kawai, N., Sasaki, S., Hayashi, Y., Takeuchi, M., Shibamoto, Y., Takahashi, S., Kojima, Y., Kohri, K.: Outcomes of robot-assisted laparoscopic prostatectomy with a posterior approach to the seminal vesicle in 150 Japanese patients. Nagoya Med J, 53: 11-25, 2013.

12. Kobayashi, D., Kawai, N., Sato, S., Naiki, T., Yamada, K., Tozawa, K., Kobayashi, T., Takahashi, S., Kohri, K.: Thermotherapy using magnetic cationic liposomes powerfully suppresses prostate cancer bone metastasis in a novel rat model. Prostate, 73: 913-922, 2013.

13. Tang, D., Kryvenko, ON., Wang, Y., Trudeau, S., Rundle, A., Takahashi, S., Shirai, T., Rybicki, BA.: Elevated 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in benign prostate and subsequent risk for prostate cancer. Int J Cancer, 133: 961-971, 2013.

14. Pitchakarn, P., Chewonarin, T., Ogawa, K., Suzuki, S., Asamoto, M., Takahashi, S., Shirai, T., Limtrakul, P.: Ellagic acid inhibits migration and invasion by prostate cancer cell lines. Asian Pac J Cancer Prev, 14: 2859-2863, 2013.

15. Yamashita, Y., Akatsuka, S., Shinjo, K., Yatabe, Y., Kobayashi, H., Seko, H., Kajiyama, H., Kikkawa, F., Takahashi, T., Toyokuni, S.: Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. PLoS One, 8: e57724, 2013.

1. Naiki, T., Asamoto, M., Toyoda-Hokaiwado, N., Naiki-Ito, A., Tozawa, K., Kohri, K., Takahashi, S., Shirai, T. Organ specific Gst-pi expression of the metastatic androgen independent prostate cancer cells in nude mice. Prostate, 72: 533-541, 2012.

2. Ogawa, K., Mamiya, S., Sato, S., Naiki-Ito, A., Suzuki, S., Takahashi, S., Cohen, SM., Shirai, T.: Immunohistochemical analysis of uroplakins, urothelial specific proteins, in sinonasal Schneiderian papillomas. Histopathology, 60: 365-369, 2012.

3. Ogawa, K., Pitchakarn, P., Suzuki, S., Chewonarin, T., Tang, M., Takahashi, S., Naiki-Ito, A., Sato, S., Takahashi, S., Asamoto, M., Shirai, T.: Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells. Cancer Sci, 103: 860-867, 2012.

4. Pitchakarn, P., Suzuki, S., Ogawa, K., Pompimon, W., Takahashi, S., Asamoto, M., Limtrakul, P., Shirai, T.: Kuguacin J, a triterpenoid from Momordica charantia leaf, modulates the progression of androgen-independent human prostate cancer cell line, PC3. Fd Chem Toxicol, 50: 840-847, 2012.

5. Takahashi, S., Uemura, H., Seeni, A., Tang, M., Komiya, M., Long, N., Ishiguro, H., Kubota, Y., Shirai, T.: Therapeutic targeting of angiotensin II receptor type 1 to regulate androgen receptor in prostate cancer. Prostate, 72: 1559-1572, 2012.

6. Toyama, T., Kondo, N., Endo, Y., Sugiura, H., Yoshimoto, N., Iwasa, M., Takahashi, S., Fujii, Y., Yamashita, H.: High expression of microRNA-210 is an independent factor indicating a poor prognosis in Japanese triple-negative breast cancer patients. Jpn J Clin Oncol, 42: 256-263, 2012.

7. Sato, S., Takahashi, S., Asamoto, M., Nakanishi, M., Wakita, T., Ogura, Y., Yatabe, Y., Shirai, T.: Histone H1 expression in human prostate cancer tissues and cell lines. Pathol Int, 62: 84-92, 2012.

8. Yasui, Y., Yamada, K., Takahashi, S., Sugiura-Ogasawara, M., Sato, K., Miyazawa, D., Sugiyama, T., Kitade, Y., Ueda, H.: PMA induces GCMa phosphorylation and alters its stability via the PKC- and ERK-dependent pathway. Biochem Biophys Res Comm, 417: 1127-1132, 2012.

9. Naitoh, I., Nakazawa, T., Hayashi, K., Miyabe, K., Shimizu, S., Kondo, H., Yoshida, M., Yamashita H., Nojiri, S., Takahashi, S., Joh, T.: A case of IgG4-related sclerosing cholangitis overlapping with primary biliary cirrhosis. Intern. Med, 51: 1695-1699, 2012.

10. Delhase, M., Kim, SY., Lee, H., Naiki-Ito, A., Chen, Y., Ahn, ER., Murata, K., Kim, SJ., Lautsch, N., Kobayashi, K. S., Shirai, T., Karin, M., Nakanishi, M.: TANK-binding kinase 1(TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci USA, 109: 177-186, 2012.

11. Shibata, MA., Khan, IA., Iinuma, M., Shirai, T.: Natural Products for Medicine. J Biomed Biotechnol, 2012: 147120, 2012.

12. Naiki-Ito, A., Kato, H., Asamoto, M., Naiki, T., Shirai, T.: Age-dependent carcinogenic susceptibility in rat liver is related to potential of gap junctional intercellular communication. Toxicol Pathol, 40: 715-721, 2012.

13. Suzuki, S., Arnold, LL., Pennington, KL., Kakiuchi-Kiyota, S., Chen, B., Lu, X., Le, XC., Cohen, SM.: Effects of co-administration of dietary sodium arsenate and 2,3-dimercaptopropane-1-sulfonic acid (DMPS) on the rat bladder epithelium. Toxicology, 299: 155-159, 2012.

14. Shirai, T., Takahashi, S., Suzuki, S., Sato, S., Naiki-Ito, A., Asamoto, M.: Experimental chemoprevention of prostate cancer: rat model. In: Shirai, T. et al. (eds.), Prostate cancer: biology, carcinogenesis and prevention. pp95-99, Princess Takamatsu Cancer Research Fund, Tokyo, 2012.

1. Sano, H., Nakazawa, T., Ando, T., Hayashi, K., Naitoh, I., Okumura, F., Miyabe, K., Yoshida, M., Takahashi, S., Ohara, H., Joh, T.: Clinical characteristics of inflammatory bowel disease associated with primary sclerosing cholangitis. J Hepatobiliary Pancreat Sci, 18: 154-161, 2011.

2. Miyaki, T., Nojiri, S., Shinkai, N., Senda, K., Kusakabe, A., Matsuura, K., Iio, E., Takahashi, S., Joh, T.: Pitavastatin improves steatosis and fibrosis in nonalcoholic steatohepatitis model rats. Hepatol Res, 41: 375-385, 2011.

3. Yamashita, H., Iwase, H., Toyama, T., Takahashi, S., Sugiura, H., Yoshimoto, N., Endo, Y., Fujii, Y., Kobayashi, S.: Estrogen receptor-positive breast cancer in Japanese women: trends in incidence, characteristics and prognosis. Ann Oncol, 22: 1318-1325, 2011.

4. Wei, M., Wanibuchi, H., Nakae, D., Tsuda, H., Takahashi, S., Hirose, M., Totsuka, Y., Tatematsu, M., Fukushima, S.: Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoxaline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21Cip/WAF1. Cancer Sci, 102: 88-94, 2011.

5. Imai, N., Kawabe, M., Hikage, T., Nojima, T., Takahashi, S., Shirai, T.: Effects on rat testis of 1.95-GHz W-CDMA for IMT-2000 cellular phones. Syst Biol Rep Med, 57: 204-209, 2011.

6. Takeshita, K., Takahashi, S., Tang, M., Seeni, A., Asamoto, M., Shirai, T.: Hypertension is positively associated with prostate cancer development in the TRAP transgenic rat model. Pathol Int, 61: 202-209, 2011.

7. Endo, Y., Toyama, T., Takahashi, S., Sugiura, H., Yoshimoto, N., Iwasa, M., Kobayashi, S., Fujii, Y., Yamashita, H.: High estrogen receptor expression and low Ki67 expression are associated with improved time to progression during first-line endocrine therapy with aromatase inhibitors in breast cancer. Int J Clin Oncol, 16: 512-518, 2011.

8. Pitchakarn, P., Suzuki, S., Ogawa, K., Pompimon, W., Takahashi, S., Asamoto, M., Limtrakul, P., Shirai, T.: Induction of G1 arrest and apoptosis in androgen-dependent human prostate cancer by Kuguacin J, a triterpenoid from Momordica charantia leaf. Cancer Lett, 306: 142-150, 2011.

9. Tanaka, M., Kataoka, H., Mabuchi, M., Sakuma, S., Takahashi, S., Tsujii, R., Akashi, H., Ohi, H., Yano, S., Morita, A., Joh, T.: Anti-cancer effects of novel photodynamic therapy with glycoconjugated chlorin for gastric and colon cancer. Anticancer Res, 31: 763-769, 2011.

10. Yoshimoto, N., Nishiyama, T., Toyama, T., Takahashi, S., Shiraki, N., Sugiura, H., Endo, Y., Iwasa, M., Fujii, Y., Yamashita, H.: Genetic and environmental predictors, endogenous hormones and growth factors and risk of estrogen receptor-positive breast cancer in Japanese women. Cancer Sci, 102: 2065-2072, 2011.

11. Yoshimoto, N., Toyama, T., Takahashi, S., Sugiura, H., Endo, Y., Iwasa, M., Fujii, Y., Yamashita, H. Distinct expressions of microRNAs that directly target estrogen receptor α in human breast cancer. Breast Cancer Res Treat, 130: 331-339, 2011.

12. Suzuki, S., Pitchakarn, P., Takeshita, K., Asamoto, M., Takahashi, S., Sato, S., Shirai, T. Roles for rat hepatocyte malignant transforming factor (HMTF) in late-stage of hepatocarcinogenesis. Toxicol Pathol, 39: 1084-1090, 2011.

13. Rybicki, BA., Neslund-Dudas, C., Bock, CH., Nock, NL., Rundle, A., Jankowski, M., Levin, AM., Beebe-Dimmer, J., Savera, AT., Takahashi, S., Shirai, T., Tang, D. Red wine consumption is inversely associated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adduct levels in prostate. Cancer Prev Res, 4: 1636-1644, 2011.

14. Ito, S., Nakasuka, K., Miyata, K., Inomata, M., Yoshida, T., Tamai, N., Suzuki, S., Murakami, Y., Suzuki, S., Sato, K.: Late in-stent restenosis after sirolimus-eluting stent implantation is related to thrombus formation-insight from a case with IVUS,OCT,and histological findings. J Cardiol, 5: 83-86, 2011.

15. Tang, M., Ogawa, K., Asamoto, M., Chewonarin, T., Suzuki, S., Tanaka, T., Shirai, T.: Effects of nobiletin on PhIP-Induced prostate and colon carcinogenesis in F344 rats. Nutr Cancer, 63: 227-33, 2011.

16. Matsumoto, H., Yakabe, Y., Saito, F., Saito, K., Sumida, K., Sekijima, M., Nakayama, K., Miyaura, H., Otsuka, M., Shirai, T.: New short term prediction method for chemical carcinogenicity by hepatic transcript profiling following 28-day toxicity tests in rats. Cancer Informatics, 10: 259-271, 2011.

17. Doi, Y., Tamano, S., Kawabe, M., Sano, M., Imai, N., Nakashima, H., Furukawa, F., Hagiwara, A., Otsuka, M., Shirai, T.: Concordance between results of medium-term liver carcinogenesis bioassays and long-tern findings for carcinogenic 2-nitropropane and non-carcinogenic 1-nitropropane in F344 rats. J Toxicol Pathol, 24: 207-213, 2011.

18. Kakiuchi-Kiyota, S., Arnold, LL., Yokohira, M., Koza-Taylor, P., Suzuki, S., Varney, M., Pennington, KL., Cohen, SM.: Evaluation of direct and indirect effects of the PPARγ agonist troglitazone on mouse endothelial cell proliferation. Toxicol Pathol, 39: 1032-1045, 2011.

19. Kakiuchi-Kiyota, S., Arnold, LL., Yokohira, M., Suzuki, S., Pennington, KL., Cohen, SM.: Evaluation of PPARγ agonists on rodent endothelial cell proliferation. Toxicology, 287: 91-98, 2011.

20. Ito, S., Yoshida, T., Suzki, S.: A case of extended late-phase in-stent restenosis after implantation of a bare-metal stent: intravascular ultrasound, optical coherence tomography and immunoihistochemical findings. J Invasive Cardiol, 23: E86-91, 2011.

21. Yokohira, M., Arnold, LL., Pennington, KL., Suzuki, S., Kakiuchi-Kiyota, S., Herbin-Davis, K., Thomas, DJ., Cohen, SM.: Effect of sodium arsenite dose administered in the drinking water on the urinary bladder epithelium of female arsenic (+3 oxidation state) methyltransferase knockout mice. Toxicol Sci, 121: 257-266, 2011.

22. Naiki, T., Hamamoto, S., Kawai, N., Naiki-Ito, A., Kojima, Y., Yasui, T., Tozawa, K., Kohri, K.: Giant retroperitoneal mucinous tumor supportively diagnosed as a dedifferentiated liposarcoma by fluorescence in situ hybridiazation of MDM2 gene. ISRN Urol, 2011: 261735, 2011.

1. Sato, S., Takahashi, S., Asamoto, M., Naiki, T., Naiki-Ito, A., Asai, K., Shirai, T.: Tranilast suppresses prostate cancer growth and osteoclast differentiation in vivo and in vitro. Prostate, 70:229-238, 2010.

2. Takahashi, S., Imai, N., Nabae, K., Wake, K., Kawai, H., Wang, J., Watanabe, S., Kawabe, M., Fujiwara, O., Ogawa, K., Tamano, S., Shirai, T.: Lack of adverse effects of whole-body exposure to a mobile telecommunication electromagnetic field on the rat fetus. Radiation Res, 173:362-372, 2010.

3. Naiki-Ito, A., Asamoto, M., Naiki, T., Ogawa, K., Takahashi, S., Sato, S., Shirai, T.: Gap junction dysfunction reduces acetaminophen hepatotoxicity with impact on apoptotic signaling and connexin 43 protein induction in rat. Toxicol Pathol, 38: 280-286, 2010.

4. Suzuki, S., Takeshita, K., Doi, Y., Asamoto, M., Takahashi, S., Naiki-Ito, A., Shirai, T.: 2-Amino-3,8-dimethylimidazo[4,5-f]quinoline (MeIQx)-induced hepatocarcinogenesis is not enhanced by CYP1A inducers, alpha- and beta-naphthoflavone; relationship to interlobular distribution of CYP1A expression. Toxicol Pathol, 38:568-582, 2010.

5. Kubota, E., Kataoka, H., Aoyama, M., Mizoshita, T., Mori, Y., Shimura, T., Sasaki, M., Takahashi, S., Asai, K., Joh, T.: Role of ES cell-expressed Ras, ERas in tumorigenicity of gastric cancer. Am J Pathol, 177:955-963, 2010.

6. Pitchakarn, P., Ogawa, K., Suzuki, S., Takahashi, S., Asamoto, M., Chewonarin, T., Limtrakul, P., Shirai, T.: Momordica Charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo. Cancer Sci, 101:2234-2240, 2010.

7. Tsuda, H., Futakuchi, M., Fukamachi, K., Shirai, T., Imaida, K., Fukushima, S., Tatematsu, M., Furukawa, F., Tamano, S., Ito, N.: A medium-term, rapid rat bioassay model for the detection of carcinogenic potential of chemicals. Toxicol Pathol, 38: 182-187, 2010.

8. Yamaguchi, T., Kanemitsu, H., Yamamoto, S., Komatsu, M., Uemura, H., Tamura, K., Shirai, T.: N,N’-bis(2-chloroethyl)- N-nitrosourea (BCNU)-induced apoptosis of neural progenitor cells in the developing fetal rat brain. J Toxicol Pathol, 23: 25-30, 2010.

9. Ichikawa, K., Tagawa, Y., Kawai, M., Asamoto, M., Shirai, T.: Promoting effects of streptozotocin-induced diabetes on Induction of hepatic preneoplastic Lesions by diethylnitrosamine in rats. J Toxicol Pathol, 23: 125-131, 2010.

10. Niida, H., Murata, K., Shimada, M., Ogawa, K., Ohta, K., Suzuki, K., Fujigaki, H., Khaw, AK., Banerjee, B., Hande, M., Miyamoto, T., Miyoshi, I., Shirai, T., Motoyama, N., Delhase, M., Appella, E., Nakanishi, M.: Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. EMBO J, 29: 3558-3570, 2010.

11. Yachida, S., Imaida, K., Yokohira, M., Hashimoto, N., Suzuki, S., Okano, K., Wakabayashi, H., Maeta, H., Suzuki, Y.: Jun activation domain binding protein 1 is overexpressed from the very early stages of hepatocarcinogenesis. Ann Surg Oncol, 17: 3386-3393, 2010.

12. Yokohira, M., Arnold, LL., Pennington, KL., Suzuki, S., Kakiuchi-Kiyota, S., Herbin-Davis, K., Thomas, DJ., Cohen, SM.: Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice. A preliminary report. Toxicol Appl Pharmacol, 246: 1-7, 2010.

13. Suzuki, S., Arnold, LL., Pennington, KL., Chen, B., Naranmandura, H., Le, XC., Cohen, SM.: Dietary administration of sodium arsenite to rats: relations between dose and urinary concentrations of methylated and thio-metabolites and effects on the rat urinary bladder epithelium. Toxicol Appl Pharmacol, 244: 99-105, 2010.

14. Suzuki, S., Arnold, LL., Pennington, KL., Kakiuchi-Kiyota, S., Wei, M., Wanibuchi, H., Cohen, SM.: Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat. Toxicol Sci, 113: 349-357, 2010.

1. Takada, H., Nakazawa, T., Ohara, H., Ando, T., Hayashi, K., Naito, I., Okumura, F., Tanaka, H., Yamada, T., Takahashi, S., Joh, T.: Role of osteopontin in calcification in autoimmune pancreatitis Dig Dis Sci, 54: 793-801, 2009.

2. Takahashi, S., Takeshita, K., Seeni, A., Sugiura, S., Tang, M., Sato, S., Kuriyama, H., Nakadate, M., Abe, K., Maeno, Y., Nagao M., Shirai, T.: Suppression of prostate cancer in a transgenic rat model via γ-tocopherol activation of caspase signaling. Prostate, 69: 644-651, 2009.

3. Harper, CE., Patel, BB., Cook, LM., Wang, J., Shirai, T., Eltoum, IA., Lamartiniere, CA.: Characterization of SV-40 Tag rats as a model to study prostate cancer. BMC Cancer, 9: 30, 2009.

4. Suzuki, S., Takeshita, K., Asamoto, M., Takahashi, S., Kandori, H., Tsujimura, K., Saito, F., Masuko, K., Shirai, T.: High mobility group box associated with cell proliferation appears to play an important role in hepatocellular carcinogenesis in rats and humans. Toxicology, 255: 160-170, 2009.

5. Takeuchi, M., Sasaki, S., Ito, M., Okada, S., Takahashi, S., Kawai, T., Suzuki, K., Oshima, H., Hara, M., Shibamoto, Y.: Urinary bladder cancer: diffusion-weighted MR imaging–accuracy for diagnosing T stage and estimating histologic grade. Radiology, 251: 112-121, 2009.

6. Inawaka, K., Kawabe, M., Takahashi, S., Doi, Y., Tomigahara, Y., Tarui, H., Abe, J., Kawamura, S., Shirai, T.: Maternal exposure to anti-androgenic compounds, vinclozolin, flutamide and procymidone, has no effects on spermatogenesis and DNA methylation in male rats of subsequent generations. Toxicol Appl Pharmacol, 237: 178-187, 2009.

7. Tanida, S., Kataoka, H., Kubota, E., Mori, Y., Sasaki, M., Ogasawara, N., Wada, T., Mizoshita, T., Shimura, T., Murakami, K., Mizushima, T., Hirata, Y., Okamoto, Y., Mabuchi, M., Ebi, M., Tanaka, M., Kamiya, T., Takahashi, S., Joh, T.: Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma. Int J Clin Oncol, 14: 266-269, 2009.

8. Ogawa, K., Nabae, K., Wang, J., Wake, K., Watanabe, S., Kawabe, M., Fujiwara, O., Takahashi, S., Ichihara, T., Tamano, S., Shirai, T.: Effects of gestational exposure to 1.95-GHz W-CDMA signals for IMT-2000 cellular phones: Lack of embryotoxicity and teratogenicity in rats. Bioelectromagnetics, 30: 205-212, 2009.

9. Tang, M., Asamoto, M., Ogawa, K., Naiki-Ito, A., Sato, S., Takahashi, S., Shirai, T.: Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor. Pathol. Int., 59: 790-796, 2009.

10. Sugiyama, M., Tanaka, Y., Kurbanov, F., Maruyama, I., Shimada, T., Takahashi, S., Shirai, T., Hino, K., Sakaida, I., Mizokami, M.: Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes. Gastroenterology, 136: 652-662, 2009.

11. Yamashita, H., Takahashi, S., Ito, Y., Yamashita, T., Ando, Y., Toyama, T., Sugiura, H.,Yoshimoto, N., Kobayashi, S., Fujii, Y., Iwase, H.: Predictors of response to exemestane as primary endocrine therapy in estrogen receptor-positive breast cancer. Cancer Sci, 100: 2028-2033, 2009.

12. Matsumoto, H., Yakabe, Y., Saito, K., Sumida, K., Sekijima, M., Nakayama, K., Miyaura, H., Saito, F., Otsuka, M., Shirai, T.: Discrimination of carcinogens by hepatic transcript profiling in rats following 28-day administration. Cancer Inform, 7: 253-269 2009.

13. Naitoh, I., Nakazawa, T., Ohara, H., Sano, H., Ando, T., Hayashi, K., Tanaka, H., Okumura, F., Miyabe, K., Yoshida, M., Takahashi, S., Joh, T.: Autoimmune pancreatitis associated with various extrapancreatic lesions during a long-term clinical course successfully treated with azathioprine and corticosteroid maintenance therapy. Intern Med, 48: 2003-2007, 2009.

14. Said, MM., Ogawa, K., Pitchakarn, P., Takahashi, S., Asamoto, M., Shirai, T.: Cyclooxygenase 2 and prostaglandin E2 are not involved in N-nitrosodiethylamine-initiated early rat hepatocarcinogenesis. J Toxicol Pathol, 22: 263-271, 2009.

15. Futakuchi, M., Nannuru, KC., Varney, ML., Sadanandam, A., Nakao, K., Asai, K., Shirai, T., Sato, SY., Singh, RK.: Transforming growth factor-beta signaling at the tumor-bone interface promotes mammary tumor growth and osteoclast activation. Cancer Sci, 100: 71-81, 2009.

16. Long, N., Hardiville, S., Pierce, A., Fukamachi, K., Futakuchi, M., Alexander, DB., Shirai, T., Tsuda, H.: Construction of a multi-functional helper-dependent adenovirus based system for cancer gene therapy. Asian Pac J Cancer Prev, 10: 939-960, 2009.

17. Naitoh, I., Nakazawa, T., Ohara, H., Ando, T., Hayashi, K., Tanaka, H., Okumura, F., Takahashi, S., Joh, T.: Endoscopic transpapillary intraductal ultrasonography and biopsy in the diagnosis of IgG4-related sclerosing cholangitis. J Gastroenterol, 44:1147-1155, 2009.

18. Suzuki, S., Arnold, LL., Pennington, KL., Chen, B., Le, XC., Cohen, SM.: Effects of an epidermal growth factor receptor inhibitor on arsenic associated toxicity in the rat bladder epithelium. Toxicol Lett, 187: 124-129, 2009.

19. Suzuki, S., Arnold, LL., Pennington, KL., Kakiuchi-Kiyota, S., Cohen, SM.: Effects of co-administration of dietary sodium arsenite and an NADPH oxidase inhibitor on the rat bladder epithelium. Toxicology, 261: 41-46, 2009.

20. Kakiuchi-Kiyota, S., Vetro, JA., Suzuki, S., Varney, ML., Han, HY., Nascimento, M., Pennington, KL., Arnold, LL., Singh, RK., Cohen, SM.: Effects of the PPARgamma agonist troglitazone on endothelial cells in vivo and in vitro: differences between human and mouse. Toxicol Appl Pharmacol, 237: 83-90, 2009.

1. Shirai, T.: Significance of chemoprevention for prostate cancer development: Experimental in vivo approaches to chemoprevention. Pathol. Int., 58: 1-16, 2008.

2. Hikosaka, A., Ogawa, K., Sugiura, S., Asamoto, M., Takeshita, F., Sato, SY., Nakanishi, M., Kohri, K., Shirai, T.: Susceptibility of p27kip1 knockout mice to urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine may not simply be due to enhanced proliferation. Int J Cancer, 122: 1222-1228, 2008.

3. Nabae, K., Hayashi, SM., Kawabe, M., Ichihara, T., Hagiwara, A., Tamano, S., Tsushima, Y., Uchida, K., Koda, T., Nakamura, M., Ogawa, K., Shirai, T.: A 90-day oral toxicity study of purple corn color, a natural food colorant, in F344 rats. Fd Chem Toxicol, 46: 774-780, 2008.

4. Yamashita, S., Takahashi, S., McDonell, N., Watanabe, N., Niwa, T., Hosoya, K., Tsujino, Y., Shirai, T., Ushijima, T.: Methylation silencing of transforming growth Factor-β receptor type II in rat prostate cancers. Cancer Res., 68: 2112-2121, 2008.

5. Yamanaka, H., Yakabe, Y., Saito, K., Sekijima, M., Sato, H., Shirai, T.: High-accuracy prediction of carcinogenicity by global quantitative analysis of post-translational modifications in a 28-day in vivo rat study. Cancer Genomics Proteomics, 5: 105-116, 2008.

6. Seeni, A., Takahashi, S., Takeshita, K., Tang, M., Sugiura, S., Sato, S., Shirai, T.: Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model. Asian Pac J Cancer Prev, 9: 7-14, 2008.

7. Hokaiwado, N., Takeshita, F., Naiki-Ito, A., Asamoto, M., Ochiya, T., Shirai, T.: Glutathione S-transferase pi mediates proliferation of androgen-independent prostate cancer cells. Carcinogenesis, 29: 1134-1138, 2008.

8. Tanaka, Y., Sanchez, LV., Sugiyama, M., Sakamoto, T., Kurbanov, F., Tatematsu, K., Roman, S., Takahashi, S., Shirai, T., Panduro, A., Mizokami, M.: Characteristics of hepatitis B virus genotype G coinfected with genotype H in chimeric mice carrying human hepatocytes. Virology, 376: 408–415, 2008.

9. Mizoguchi, Y., Ogawa, K., Futakuchi, M., Takahashi, S., Hirose, M., Shirai, T.: Differences in expression patterns of cell cycle regulators after cessation of genotoxic and non-genotoxic carcinogen treatment in the rat forestomach. J Toxicol Pathol, 21: 77-87, 2008.

10. Hagiwara, H., Sato, H., Ohde, Y., Takano, Y., Seki, T., Ariga, T., Hokaiwado, N., Asamoto, M., Shirai, T., Nagashima, Y., Yano, T.: 5-Aza-2’-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene. Br J Pharmacol, 153: 1373-1381, 2008.

11. Nakagawa, M., Hara, M., Shibamoto, Y., Yano, M., Takahashi, S.: CT findings of bronchial glandular papilloma. J Thorac Imaging, 23: 210-212, 2008.

12. Nakagawa, M., Hara, M., Oshima, H., Shibamoto, Y., Sato, Y., Kondo, S., Suzuki, T., Takahashi, S.: Pleural bronchogenic cysts: Imaging findings. J Thorac Imaging, 23: 284-288, 2008.

13. Kawabe, M., Futakuchi, M., Tamano, S., Shirai, T., Hirose, M.: Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesis model. Fd Chem Toxicol, 46: 2758-2763, 2008.

14. Sato, S., Futakuchi, M., Ogawa, K., Asamoto, M., Nakao, K., Asai, K., Shirai, T.: Transforming growth factor beta derived from bone matrix promotes cell proliferation of prostate cancer and osteoclast activation-associated osteolysis in the bone microenvironment. Cancer Sci, 99: 316-323, 2008.

15. Wang, Z., Luque, RM., Kineman, RD., Ray, VH., Christov, KT., Lantvit, DD., Shirai, T., Hedayat, S., Unterman, TG., Bosland, MC., Prins, GS., Swanson, SM.: Disruption of growth hormone signaling retards prostate carcinogenesis in the probasin/TAg rat. Endocrinology, 149: 1366-1376, 2008.

16. Kawai, N., Futakuchi, M., Yoshida, T., Ito, A., Sato, S., Naiki, T., Honda, H., Shirai, T., Kohri, K.: Effect of heat therapy using magnetic nanoparticles conjugated with cationic liposomes on prostate tumor in bone. Prostate, 68: 784-792, 2008.

17. Toyama, T., Yamashita, H., Kondo, N., Okuda, K., Takahashi, S., Sasaki, H., Sugiura, H., Iwase, H., Fujii, Y.: Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers. BMC Cancer, 8: 309, 2008.

18. Uemura, H., Ishiguro, H., Ishiguro, Y., Hoshino, K., Takahashi, S., Kubota, Y.: Angiotensin II induces oxidative stress in prostate cancer. Mol Cancer Res, 6: 250-258, 2008.

19. Suzuki, S., Arnold, LL., Ohnishi, T., Cohen, SM.: Effects of inorganic arsenic on the rat and mouse urinary bladder. Toxicol Sci, 106: 350-363, 2008.

20. Nascimento, MG., Suzuki, S., Wei, M., Tiwari, A., Arnold, LL., Lu, X., Le, XC., Cohen, SM.: Cytotoxicity of combinations of arsenicals on rat urinary bladder urothelial cells in vitro. Toxicology, 249: 69-74, 2008.

1. Sumida, K., Saito, K., Oeda, K., Otsuka, M., Tsujimura, K., Miyaura, H., Nakayama, K., Kawano, Y., Kawakami, Y., Asamoto, M., Shirai, T.: Optimization of an animal test protocol for toxicogenomics studies (i); requirement study of a protocol. J Toxicol Sci, 32: 19-32, 2007.

2. Sumida, K., Saito, K., Oeda, K., Otsuka, M., Tsujimura, K., Miyaura, H., Nakayama, K., Kawano, Y., Kawakami, Y., Asamoto, M., Shirai, T.: Optimization of an animal test protocol for toxicogenomics studies (ii); a-cross-laboratory gene expression analysis. J Toxicol Sci, 32: 33-45, 2007.

3. Tang, M., Ogawa, K., Asamoto, M., Hokaiwado, N., Seeni, A., Suzuki, S., Takahashi, S., Tanaka, T., Ichikawa, K., Shirai, T.: Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells. Cancer Sci, 98: 471-477, 2007.

4. Cho, YM., Takahashi, S., Asamoto, M., Suzuki, S., Tang, M., Shirai, T.: Suppressive effects of antiandrogens, finasteride and flutamide, on development of prostatic lesions in a transgenic rat model. Prostate Cancer Prostatic Dis, 10: 378-383, 2007.

5. Sugiyama, M., Tanaka, Y., Sakamoto, T., Maruyama, I., Shimada, T., Takahashi, S., Shirai, T., Kato, H., Nagao, M., Miyakawa, Y., Mizokami, M.: Early dynamics of hepatitis B virus in chimeric mice carrying human hepatocytes monoinfected or coinfected with genotype G. Hepatology, 45: 929-937, 2007.

6. Imazawa, T., Nishikawa, A., Miyauchi, M., Okazaki, K., Takahashi, S., Umemura, T., Hirose, M.: DNA adduct formation, nucleolar segregation and cell proliferation in rats treated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. J Toxicol Pathol, 20: 39-47, 2007.

7. Tsuda, H., Iigo, M., Takasuka, N., Ueda, S., Ohshima, Y., Fukamachi, K., Shirai, T., Hirano, S., Matsuda, E., Wakabayashi, K.: Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats. Fd Chem Toxicol, 45: 1013-1019, 2007.

8. Yamanaka, H., Yakabe, Y., Saito, K., Sekijima, M., Shirai, T.: Quantitative proteomic analysis of rat liver for carcinogenicity prediction in a 28-day repeated dose study. Proteomics, 7: 781-795, 2007.

9. Shirai, T., Ichihara, T., Wake, K., Watanabe, S., Yamanaka, Y., Kawabe, M., Taki, M., Fujiwara, O., Wang, J., Takahashi, S., Tamano, S.: Lack of promoting effects of chronic exposure to 1.95-GHz W-CDMA signals for IMT-2000 cellular system on development of N-ethylnitrosourea-induced central nervous system tumors in F344 rats. Bioelectromagnetics, 28: 562-572, 2007.

10. Hokaiwado, N., Asamoto, M., Futakuchi, M., Ogawa, K., Takahashi, S., Shirai, T.: Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication. J Membrane Biol, 218: 101-106, 2007.

11. Naiki-Ito, A., Asamoto, M., Hokaiwado, N., Takahashi, S., Yamashita, H., Tsuda, H., Ogawa, K., Shirai, T.: Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens. Cancer Res, 67: 11353-11358, 2007.

12. Futakuchi, M., Hirose, M., Kawabe, M., Yamaguchi, T., Sato, S., Shirai, T.: Combined chemopreventive effects of perilla or corn oil and indomethacin in a rat medium-term multiorgan carcinogenesis model. J Toxicol Pathol, 20: 245-252, 2007.

13. Toyama, T., Zhang, Z., Nishio, M., Hamaguchi, M., Kondo, N., Iwase, H., Iwata, H., Takahashi, S., Yamashita, H., Fujii, Y.: Association of TP53 codon 72 polymorphisms and the outcome of adjuvant therapy in breast cancer patients. Breast Cancer Res, 9: R34, 2007.

14. Kato, T., Hashimoto, Y., Okada, S., Tozawa, K., Takahashi, S., Kohri, K.: Carbohydrate antigen 19-9-positive prostatic ductal adenocarcinoma effectively treated with cisplatin and gemcitabine. Int J Urol, 14:1103-1106, 2007.

1. Hikosaka, A., Futakuchi, M., Ogiso, T., Suzuki, S., Kohri, K., Shirai, T.: Lack of prophylactic effect of incadronate on skeletal lesions associated with implants of prostate cancer. Eur Urol., 49: 176-182, 2006.

2. Ohara, H., Nakazawa, T., Sano, H., Joh, T., Takahashi, S.: Histopathologic similarities of inflammatory pseudotumor to autoimmune pancreatitis: A morphologic and immunohistochemical study of 4 cases. Pancreas, 32:115-117, 2006.

3. Takahashi, S., Suzuki, S., Takahashi, S., Inaguma, S., Asamoto, M., Shirai, T.: Differences between latent and clinical prostate carcinomas: Lower cell proliferation activity in latent cases. Prostate, 66: 211-217, 2006.

4. Kuribayashi, M., Asamoto, M., Suzuki, S., Hokaiwado, N., Ogawa, K., Shirai, T.: Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences. Cancer Lett, 232: 289-299, 2006.

5. Shirai, T., Ogawa, K., Takahashi, S.: Carcinogenic effects of mixtures of chemicals. J Toxicol Pathol, 19: 1-13, 2006.

6. Suzuki, S., Takahashi, S., Takahashi, S., Takeshita, K., Hikosaka, A., Wakita, T., Nishiyama, N., Fujita, T., Okamura, T., Shirai, T.: Expression of prothymosin alpha is correlated with development and progression in human prostate cancers. Prostate, 66: 463-469, 2006.

7. Kawabe, M., Sano, M., Hagiwara, A., Tamano, S., Suzuki, S., Shirai, T.: Lack of carcinogenicity of L-isoleucine in F344/DuCrj rats. Fd Chem Toxicol, 44: 278-285, 2006.

8. Kawai, N., Ito, A., Nakahara, Y., Honda, H., Kobayashi, T., Futakuchi, M., Shirai, T., Tozawa, K., Kohri, K.: Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core. Prostate, 66: 718-727, 2006.

9. Ogawa, K., Masutani, M., Kato, K., Tang, M., Kamada, N., Suzuki, H., Nakagama, H., Sugimura, T., Shirai, T.: Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice. Cancer Lett, 236: 32-38, 2006.

10. Sunden, Y., Suzuki, T., Orba, Y., Umemura, T., Asamoto, M., Nagashima, K., Tanaka, S., Sawa, H.: Characterization and application of polyclonal antibodies that specifically recognize JC virus large T antigen. Acta Neuropathol, 111: 379-387, 2006.

11. Said, MM., Hokaiwado, N., Tang, M., Ogawa, K., Suzuki, S., Ghanem, HM., Esmat, AY., Asamoto, M., Rafaie, FM., Shirai, T.: Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist. Cancer Sci, 97: 459-467, 2006.

12. Yamauchi, A., Kawai, K., Tsukamoto, S., Ideyama, Y., Shirai, T., Akaza, H.: Persistence of prostatic intraepithelial neoplasia after effective chemoprevention of microscopic prostate cancer with antiandrogen in a rat model. J Urol, 175: 348-352, 2006.

13. Murasaki, T., Asamoto, M., Hokaiwado, N., Ogawa, K., Shirai, T.: Limited effects of disrupted gap junctions in the liver on multi-organ carcinogenesis induced by diisopropanolnitrosamine in the mutant connexin 32 transgenic rat. J Toxicol Pathol, 19: 93-97, 2006.

14. Romanenko, AM., Morimura, K., Kinoshita, A., Wanibuchi, H., Takahashi, S., Zaparin, WK., Vinnichenko, WI., Vozianov, AF., Fukushima, S.: Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident. Cancer Sci., 97:1168-1174, 2006.

15. Tamano, S., Kawabe, M., Ichihara, T., Hagiwara, A., Sano, M., Asamoto, M., Shirai, T.: Close relation of transforming growth factor-α positive hepatic foci to hepatocellular tumor development in the rat. J Toxicol Pathol, 19: 99-106, 2006.

16. Zhu, A., Rashid, A., Cleary, K., Abbruzzese, JL., Friess, H., Takahashi, S., Shirai, T., Li, D.: Detection of 2-amino-1-methy1-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in human pancreatic tissues. Biomarkers, 11: 319-328, 2006.

17. Imai, N., Doi, Y., Nabae, K., Tamano, S., Hagiwara, A., Kawabe, M., Ichihara, T., Ogawa, K., Shirai, T.: Lack of hinokitiol (beta-thujaplicin) carcinogenicity in F344/DuCrj rats. J Toxicol Sci, 31: 357-370, 2006.

18. Nabae, K., Doi, Y., Takahashi, S., Ichihara, T., Toda, C., Ueda, K., Okamoto, Y., Kojima, N., Tamano, S., Shirai, T.: Toxicity of di(2-ethylhexyl)phthalate (DEHP) and di(2-ethylhexyl)adipate (DEHA) under conditions of renal dysfunction induced with folic acid in rats: Enhancement of male reproductive toxicity of DEHP is associated with an increase of the mono-derivative. Reprod Toxicol, 22: 411-417, 2006.

19. Okamura, T., Uemoto, Y., Yamashita, K., Suzuki, S., Shirai, T., Hashimoto, Y., Kohri, K.: Pitfalls with MRI evaluation of prostate cancer detection: comparison of findings with histopathological assessment of retropubic radical prostatectomy specimens. Urol Int, 77: 301-306, 2006.

20. Nakayama, K., Kawano Y., Kawakami, Y., Moriwaki, N., Sekijima, M., Otsuka, M., Yakabe, Y., Miyaura, H., Saito, K., Sumida, K., Shirai, T.: Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a 28-day repeat-dose toxicity study. Toxicol Appl Pharmacol, 217: 299-307, 2006.

21. Doi, Y., Ichihara, T., Hagiwara, A., Imai, N., Tamano, S., Orikoshi, H., Ogasawara, K., Sasaki, Y., Nakamura, M., Shirai, T.: A ninety-day oral toxicity study of a new type of processed gum arabic, from Acacia tree (Acacia senegal) exudates, in F344 rats. Fd Chem Toxicol, 44: 560-566, 2006.

22. Tsujimura, K., Asamoto, M., Suzuki, S., Hokaiwado, N., Ogawa, K., Shirai, T.: Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells. Cancer Sci, 97: 1002-1010, 2006.

1. Kioi, M., Takahashi, S., Kawakami, M., Kawakami, K., Kreitman, RJ., Puri, RK.: Expression and targeting of interleukin-4 receptor for primary and advanced ovarian cancer therapy. Cancer Res, 65: 8388-8396, 2005.

2. Shirai, T., Kawabe, M., Ichihara, T., Fujiwara, O., Taki, M., Watanabe, S., Wake, K., Yamanaka, Y., Imaida, K., Asamoto, M., Tamano, S.: Chronic exposure to a 1.439 GHz electromagnetic field used for cellular phones does not promote N-ethylnitrosourea induced central nervous system tumors in F344 rats. Bioelectromagnetics, 26: 59-68, 2005.

3. Ichihara, T., Miyashita, K., Kawabe, M., Imaida, K., Asamoto, M., Ogiso, T., Tamano, S., Hirose, M., Shirai, T.: Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat. J Toxicol Sci, 30: 1-6, 2005.

4. Ito, A., Asamoto, M., Hokaiwado, N., Takahashi, S., Shirai, T.: Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells. Cancer Lett, 219: 105-112, 2005.

5. Ozaki, M., Ozaki, K., Watanabe, T., Uwagawa, S., Okuno, Y., Shirai, T.: Susceptibilities of p53 knockout and rasH2 transgenic mice to urethane-induced lung carcinogenesis are inherited from their original strains. Toxicol Pathol, 33: 267-271, 2005.

6. Ichihara, T., Tamano, S., Yoshino, H., Imaida, K., Ishikawa, H., Kakizoe, T., Shirai, T.: Lack of chemoprevention or promotion effects of docosahexaenoic acid on small intestine, colon, liver, lung, thyroid, esophagus, kidney, and forestomach carcinogenesis in a rat medium-term multi-organ carcinogenesis model. J Toxicol Pathol, 18: 53-59, 2005.

7. Ichihara, T., Imai, N., Toda, Y., Hagiwara, A., Tamano, S., Shirai, T.: Evidence of a threshold dose for promotion of hepatocarcinogenesis by hexachlorobenzene in a rat medium-term liver bioassay. J Toxicol Pathol, 18: 7-11, 2005.

8. Yamashita, S., Suzuki, S., Nomoto, T., Kondo, Y., Wakazono, K., Tsujino, Y., Sugimura, T., Shirai, T., Homma, Y., Ushijima, T.: Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged. Cancer Res., 65: 2610-2616, 2005.

9. Lynch, CC., Hikosaka, A., Acuff, HB., Martin, MD., Kawai, N., Singh, RK., Vargo-Gogola, TC., Begtrup, JL., Peterson, TE., Fingleton, B., Shirai, T., Matrisian, LM., Futakuchi, M.: MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell, 7: 485-496, 2005.

10. Ogawa, K., Asamoto, M., Suzuki, S., Tsujimura, K., Shirai, T.: Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions. Med Mol Morphol, 38: 23-29, 2005.

11. Yamada, T., Kuno, A., Ogawa, K., Tang, M., Masuda, K., Nakamura, S., Ando, T., Okamoto, T., Ohara, H., Nomura, T., Joh, T., Shirai, T., Itoh, M.: Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats. J Pharmacol Exp Ther, 313: 36-45, 2005.

12. Fukushima, S., Wanibuchi, H., Morimura, K., Nakae, D., Tsuda, H., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F.: Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver. Cancer Lett, 222: 11-15, 2005.

13. Kawabe, M., Ichihara, T., Sano, M., Hagiwara, A., Tamano, S., Ogawa, K., Shirai, T.: Lack of carcinogenicity of silicone resin (KS66) in F344 rats. Fd Chem Toxicol, 43: 1065-1071, 2005.

14. Sugiura, S., Asamoto, M., Hokaiwado, N., Hirose, M., Shirai, T.: Harman and norharman suppressed but NaNO2 enhanced the development of preneoplastic liver cell foci in 2-amino-3,8-dimethylimidazo- [4,5-f]quinoxaline (MeIQx)-treated rats. J Toxicol Pathol, 18: 99-104, 2005.

15. Ikeda, Y., Cho, YM., Takahashi, S., Tang, M., Asamoto, M., Ogawa, K., Shirai, T.: Equivocal impact of transplacental and lactational exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine, on prostate and colon lesion development in F344 rats. Cancer Lett, 224: 23-30, 2005.

16. Nabae, K., Ichihara, T., Hagiwara, A., Hirota, T., Toda, Y., Tamano, S., Nishino, M., Ogasawara, T., Sasaki, Y., Nakamura, M., Shirai, T.: A 90-day oral toxicity study of beta-carotene derived from Blakeslea trispora, a natural food colorant, in F344 rats. Fd Chem Toxicol, 43: 1127-1133, 2005.

17. Kandori, H., Suzuki, S., Asamoto, M., Murasaki, T., Tang, M., Ogawa, K., Shirai, T.: Influence of atrazine administration and reduction of calorie intake on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Sci, 96: 221-226, 2005.

18. Okamoto, T., Yamada, T., Kuno, A., Ogawa, K., Tang, M., Sano, H., Ohara, H., Nakao, H., Kataoka, H., Shirai, T., Itoh, M.: FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration. Pancreas, 30: e64-e70, 2005.

19. Kawai, N., Ito, A., Nakahara, Y., Futakuchi, M., Shirai, T., Honda, H., Kobayashi, T., Kohri, K.: Anticancer effect of hyperthermia on prostate cancer mediated by magnetite cationic liposomes and immune-response induction in transplanted syngeneic rats. Prostate, 64: 373-381, 2005.

20. Hagiwara, A., Yoshino, H., Sano, M., Kawabe, M., Tamano, S., Sakaue, K., Nakamura, M., Tada, M., Imaida, K., Shirai, T.: Thirteen-week feeding study of thaumatin (a natural proteinaceous sweetener), sterilized by electron beam irradiation, in Sprague-Dawley rats. Fd Chem Toxicol, 43: 1297-1302, 2005.

21. Zhao, L., Futakuchi, M., Suzuki, S., Ohhara, Y., Hashimoto, T., Suzuki, T., Manabe, T., Shirai, T.: Kinetics of marked development of lung metastasis of rat prostatic carcinomas transplanted in syngeneic rats. Clin Exp Metastasis, 22: 309-318, 2005.

22. Kuribayashi, M., Wang, J., Fujiwara, O., Doi, Y., Nabae, K., Tamano, S., Ogiso, T., Asamoto, M., Shirai, T.: Lack of effects of 1439 MHz electromagnetic near field exposure on the blood-brain barrier in immature and young rats. Bioelectromagnetics, 26: 578-588, 2005.

23. Yoshino, H., Futakuchi, M., Cho, YM., Ogawa, K., Takeshita, F., Imai, N., Tamano, S., Shirai, T.: Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. Clin Exp Metastasis, 22: 441-447, 2005.

24. Yoshino, H., Imai, N., Nabae, K., Doi, Y., Tamano, S., Ogawa, K., Shirai, T.: Thirteen-week oral toxicity study of dokudami extract (Houttuynia Cordata Thunb.) in F344/DuCrj rats. J Toxicol Pathol, 18: 175-182, 2005.

25. Yoshino, H., Nabae, K., Doi, Y., Ichihara, T., Tamano, S., Suzuki, S., Shirai, T.: Lack of effects of gestational and lactational exposure to 4-nonylphenol on PhIP-induced rat prostate carcinogenesis. J Toxicol Pathol, 18: 183-188, 2005.

26. Hokaiwado, N., Asamoto, M., Ogawa, K., Shirai, T.: Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat. Toxicol Pathol, 33: 695-701, 2005.

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