1. Kawakami M., Kawakami, K., Takahashi, S., Abe, M., Puri, RK.: Analysis of interleukin-13 receptor α2 expression in human pediatric brain tumors. Cancer, 101: 1036-1042, 2004.

2. Futakuchi, M., Ogawa, K., Tamano, S., Takahashi, S., Shirai, T.: Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma. Cancer Sci, 95: 18-24, 2004.

3. Hokaiwado, N., Asamoto, M., Tsujimura, K., Hirota, T., Ichihara, T., Satoh, T., Shirai, T.: Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system. Cancer Sci, 95: 123-130, 2004.

4. Tsutsumi, T., Ichihara, T., Kawabe, M., Yoshino, H., Asamoto, M., Suzuki, S., Shirai, T.: Renal toxicity induced by folic acid is associated with the enhancement of male reproductive toxicity of di(n-butyl)phthalate in rats. Reprod Toxicol, 18: 35-42, 2004.

5. Suzuki, S., Asamoto, M., Tsujimura, K., Shirai, T.: Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue. Carcinogenesis, 25: 439-443, 2004.

6. Hikosaka, A., Asamoto, M., Hokaiwado, N., Kato, K., Kuzutani, K., Kohri, K., Shirai, T.: Inhibitory effects of soy isoflavones on rat prostate carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 25: 381-387, 2004.

7. Kikuchi, M., Inagaki, T., Ogawa, K., Banno, S., Matsumoto, Y., Ueda, R., Hanaki, H.: Histopathological investigation of salivary glands in the asymptomatic elderly. Arch Gerontol Geriatr, 38: 131-138, 2004.

8. Ogawa, K., Tada, T., Takeuchi, Y., Suenaga, M., Suzuki, S., Shirai, T.: Reactive angioendotheliomatosis of the intestine. Am J Surg Pathol, 28: 257-261, 2004.

9. Ogawa, K., Tada, T., Takahashi, S., Sugiyama, N., Inaguma, S., Takahashi, SS., Shirai, T.: Malignant solitary fibrous tumor of the meninges. Virchows Arch, 444: 459-464, 2004.

10. Orita, S., Hirose, M., Takahashi, S., Imaida, K., Ito, N., Shudo, K., Ohigashi, H., Murakami, A., Shirai, T.: Modifying effects of 1′-acetoxychavicol acetate (ACA) and the novel synthetic retinoids Re-80, Am-580 and Am-55P in a two-stage carcinogenesis model in female rats. Toxicol Pathol, 32: 250-257, 2004.

11. Fukushima, S., Wanibuchi, H., Morimura, K., Iwai, S., Nakae, D., Kishida, H., Tsuda, H., Uehara, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F.: Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine. Toxicol Sci, 80: 109-114, 2004.

12. Qin, LQ., Xu, JY., Wang, PY., Ganmaa, D., Li, J., Wang, J., Kaneko, T., Hoshi, K., Shirai, T., Sato, A.: Low-fat milk promotes the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. Int J Cancer, 110: 491-496, 2004.

13. Asamoto, M., Hokaiwado, N., Murasaki, T., Shirai, T.: Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals. Hepatology, 40: 205-210, 2004.

14. Inaguma, S., Takahashi, S., Imaida, K., Suzuki, S., Shirai, T.: p-Nonylphenol pretreatment during the late neonatal period has no effect on 3,2′-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats. Cancer Lett, 212: 159-166, 2004.

15. Suzuki, S., Sato, K., Katada, E., Kuno, Y., Mizoguchi, N., Tokuda, H., Inaguma, S., Asamoto, M., Dohi, Y.: Periampullary somatostatinoma and multiple gastrointestinal stromal tumors associated with von Recklinghausen’s disease. J Gastroenterol, 39: 1011-1012, 2004.

16. Jin, M., Sawa, H., Suzuki, T., Shimizu, K., Makino, Y., Tanaka, S., Nojima, T., Fujioka, Y., Asamoto, M., Suko, N., Fujita, M., Nagashima, K.: Investigation of simian virus 40 large T antigen in 18 autopsied malignant mesothelioma patients in Japan. J Med Virol, 74: 668-676, 2004.

17. Ohnishi, H., Asamoto, M., Tsujimura, K., Hokaiwado, N., Takahashi, S., Ogawa, K., Kuribayashi, M., Ogiso, T., Okuyama, H., Shirai, T.: Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo. Cancer Sci, 95: 936-942, 2004.

18. Naito, A., Suzuki, A., Ueda, S., Nomoto, H., Toriyama-Baba, H., Asamoto, M., Tsuda, H.: Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats. Cancer Sci, 95: 399-403, 2004.

19. Uchida, A., Oka, Y., Aoyama, M., Suzuki, S., Yokoi, T., Katano, H., Mase, M., Tada, T., Asai, K., Yamada, K.: Expression of myelencephalon-specific protease in transient middle cerebral artery occlusion model of rat brain. Brain Res Mol Brain Res, 126: 129-136, 2004.

1. Ito, N., Tamano, S., Shirai, T.: A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals. Cancer Sci. 94: 3-8, 2003.

2. Neal, GE., Judah, DJ., Hard, GG., Ito, N.: Differences in ethoxyquin nephrotoxicity between male and female F344 rats. Fd Chem Toxicol, 41: 193-200, 2003.

3. Takahashi, S., Suzuki, S., Inaguma, S., Ikeda, Y., Cho, YM., Hayashi, N., Inoue, T., Sugimura, Y., Nishiyama, N., Fujita, T., Chao, J., Ushijima, T., Shirai, T.: Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers. Prostate. 54: 187-193, 2003.

4. Cho, YM., Takahashi, S., Asamoto, M., Suzuki, S., Inaguma, S., Hokaiwado, N., Shirai, T.: Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: Lack of influence of carcinogen or testosterone treatment. Cancer Sci, 94: 153-157, 2003.

5. Fukushima, S., Wanibuchi, H., Morimura, K., Wei, M., Kanae, D., Konishi, Y., Tsuda, H., Takasuka, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F.: Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Lett, 191: 35-40, 2003.

6. Suzuki, T., Mizuo, K., Nakazawa, H., Funae, Y., Fushiki, S., Fukushima, S., Shirai, T., Narita, M.: Prenatal and neonatal exposure to bisphenol-A enhances the central dopamine D1 receptor-mediated action in mice: Enhancement of the methamphetamine-induced abuse state. Neuroscience, 117: 639-644, 2003.

7. Zhu, J., Chang, P., Bondy, ML., Sahin, AA., Singletary, SE., Takahashi, S., Shirai, T., Li, D.: Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer. Cancer Epidemiol Biomarkers Prev, 12: 830-837, 2003.

8. Sugiura, S., Ogawa, K., Hirose, M., Takeshita, F., Asamoto, M., Shirai, T.: Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate. Carcinogenesis, 24: 547-553, 2003.

9. Takeshita, F., Ogawa, K., Asamoto, M., Shirai, T.: Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Lett, 194: 25-35, 2003.

10. Ito, A., Asamoto, M., Hokaiwado, N., Shirai, T.: Regulation of cell proliferation by induction of p21/WAF1 in rat bladder carcinoma cells using the Cre-loxP system. Cancer Lett, 193: 183-188, 2003.

11. Kuno, A., Yamada, T., Masuda, K., Ogawa, K., Sogawa, M., Nakamura, S., Nakazawa, T., Ohara, H., Nomura, T., Joh, T., Shirai, T., Itoh, M.: Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats. Gastroenterology, 124: 1010-1019, 2003.

12. Cheng, JL., Futakuchi, M., Ogawa, K., Iwata, T., Kasai, M., Tokudome, S., Hirose, M., Shirai, T.: Dose response study of conjugated fatty acid derived from safflower oil on mammary and colon carcinogenesis pretreated with 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH) in female Sprague-Dawley rats. Cancer Lett, 196: 161-168, 2003.

13. Cheng, J., Ogawa, K., Kuriki, K., Yokoyama, Y., Kamiya, T., Seno, K., Okuyama, H., Wang, J., Luo, C., Fujii, T., Ichikawa, H., Shirai, T., Tokudome, S.: Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors. Cancer Lett, 193: 17-24, 2003.

14. Hagiwara, A., Imai, N., Ichihara, T., Sano, M., Tamano, S., Aoki, H., Yasuhara, K., Koda, T., Nakamura, M., Shirai, T.: A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats. Fd Chem Toxicol, 41: 1157-1164, 2003.

15. Akagi, K., Sano, M., Ogawa, K., Hirose, M., Goshima, H., Shirai, T.: Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats. Toxicol Pathol, 31: 388-396, 2003.

16. Ichihara, T., Yoshino, H., Imai, N., Tsutsumi, T., Kawabe, M., Tamano, S., Inaguma, S., Suzuki, S., Shirai, T.: Lack of carcinogenic risk in the prostate with transplacental and lactational exposure to bisphenol A in rats. J Toxicol Sci, 28: 165-171, 2003.

17. Kato, T., Miyamoto, M., Date, T., Yasui, K., Taya, C., Yonekawa, H., Ohue, C., Yagi, S., Seki, E., Hirano, T., Fujimoto, J., Shirai, T., Wakita, T.: Repeated hepatocyte injury promotes hepatic tumorigenesis in hepatitis C virus transgenic mice. Cancer Sci. 94: 679-685, 2003.

18. Hagiwara, A., Imai, N., Doi, Y., Nabae, K., Hirota, T., Yoshino, H., Kawabe, M., Tsushima, Y., Aoki, H., Yasuhara, K., Koda, T., Nakamura, M., Shirai, T.: Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats. Cancer Lett. 199: 9-17, 2003.

19. Inaguma, S., Takahashi, S., Ohnishi, H., Suzuki, S., Cho, YM., Shirai, T.: High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) prostate carcinogenesis. Cancer Sci., 94: 974-979, 2003.

20. Yoshida, M., Shimomoto, T., Katashima, S., Shirai, T., Nakae, D., Watanabe, G., Taya, K., Maekawa, A.: Effects of maternal exposure to nonylphenol on growth and development of the female reproductive system and uterine carcinogenesis in rats. J Toxicol Pathol, 16: 259-266, 2003.

21. Hokaiwado, N., Asamoto, M., Cho, YM., Tsuda, H., Shirai, T.: Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Sci, 94: 1042-1045, 2003.

22. Yamada, T., Kuno, A., Masuda, K., Ogawa, K., Sogawa, M., Nakamura, S., Ando, T., Sano, H., Nakazawa, T., Ohara, H., Nomura, T., Joh, T., Itoh, M.: Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats. J Pharmacol Exp Ther, 307: 17-23, 2003.

23. Hagiwara, A., Sano, M., Ichihara, T., Yoshino, H., Miyata, E., Tamano, S., Aoki, H., Yukawa, C., Koda, T., Nakamura, M., Shirai, T.: Four-week oral toxicity study of 1-carboxy-5,7-dibromo-6-hydroxy-2,3,4- trichloroxanthone (HXCA), an impurity of Phloxine B, in F344 rats. J Toxicol Sci, 28: 445-453, 2003.

24. Nakamura, S., Yamada, T., Hashimoto, T., Takahashi, S., Sogawa, M., Ohara, H., Nakazawa, T., Sano, H., Kuno, A., Joh, T., Nomura, T., Arakawa, T., Itoh, M.: Estradiol alleviates acinar cell apoptosis and chronic pancreatitis in male Wistar Bonn/Kobori rats. Pancreas, 26:e59-e66, 2003.

25. Hasegawa, C., Yamada, T., Ohara, H., Nakazawa, T., Sano, H., Ando, H., Kunimatsu, M., Ozaki, Y., Takahashi, S., Nomura, T., Joh, T., Itoh, M.: Taurochenodeoxycholic acid-induced biphasic hepatotoxicity in isolated perfused rat liver: Roles of Ca2+ and calpain. Hepatogastroenterology, 50: 972-978, 2003.

26. Yamada, T., Takahashi, S., Masuda, K., Ohara, H., Nakazawa, T., Sano, H., Ando, T., Nakamura, S., Kobayashi, S., Kuno, A., Aoki, S., Nomura, T., Joh, T., Itoh, M.: Kupffer cell depletion attenuates colonic and extracolonic granulomatous inflammation in chronic colitis. J Lab Clin Med, 142: 268-277, 2003.

27. Shirai, T., Asamoto, M.: Application of toxicogenomics to the endocrine disruption issue. Pure Appl Chem, 75: 2419-2422, 2003.

28. Imaida, K., Tamano, S., Hagiwara, A., Fukushima, S., Shirai, T., Ito, N.: Application of rat medium-term bioassays for detecting carcinogenic and modifying potentials of endocrine active substances. Pure Appl Chem, 75: 2491-2495, 2003.

1. Hagiwara, A., Sano, M., Tanaka, H., Kawabe, M., Tamano, S., Kadota, T., Yanagisawa, T., Maemura, S., Ito, N., Shirai, T.: Lack of enhancing effect of two Kampo medicines, Sho-saiko-to (TJ-9) and Sairei-to (TJ-114), on rat urinary bladder carcinogenesis initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Teratog Carcinog Mutagen, 22: 41-50, 2002.

2. Takahashi, S., Suzuki, S., Inaguma, S., Ikeda, Y., Cho, YM., Nishiyama, N., Fujita, T., Inoue, T., Hioki, T., Sugimura, Y., Ushijima, T., Shirai, T.: Down-regulation of human X-box binding protein 1 (hXBP-1) expression correlates with tumor progression in human prostate cancers. Prostate, 50: 154-161, 2002.

3. Hagiwara, A., Yoshino, H., Ichihara, T., Kawabe, M., Tamano, S., Aoki, H., Koda, T., Nakamura, M., Imaida, K., Ito, N., Shirai, T.: Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine. J Toxicol Sci, 27: 57-68, 2002.

4. Futakuchi, M., Hirose, M., Imaida, K., Takahashi, S., Ogawa, K., Asamoto, M., Miki, T., Shirai, T.: Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats. Carcinogenesis, 23: 283-287, 2002.

5. Asamoto, M., Hokaiwado, N., Cho, YM., Shirai, T.: Effects of genetic background on prostate and taste bud carcinogenesis due to SV40 T antigen expression under probasin gene promoter control. Carcinogenesis, 23: 463-467, 2002.

6. Hirose, M., Nishikawa, A., Shibutani, M., Imai, T., Shirai, T.: Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats. Environ Mol Mutagen, 39: 271-278, 2002.

7. Futakuchi, M., Cheng, JL., Hirose, M., Kimoto, N., Cho, YM., Iwata, T., Kasai, M., Tokudome, S., Shirai, T.: Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Cancer Lett, 178: 131-139, 2002.

8. Kuroda, H., Ohtsuru, A., Futakuchi, M., Kawashita, Y., Nagayama, Y., Fukuda, E., Namba, H., Shirai, T., Kanematsu, T., Yamashita, S.: Distinctive gene expression of receptor-type tyrosine kinase families during rat hepatocarcinogenesis. Int J Mol Med, 9: 473-480, 2002.

9. Takahashi, S., Suzuki, S., Inaguma, S., Cho, YM., Ikeda, Y., Hayashi, N., Inoue, T., Sugimura, Y., Nishiyama, N., Fujita, T., Ushijima, T., Shirai, T.: Down-regulation of Lsm1 is involved in human prostate cancer progression. Br J Cancer, 86: 940-946, 2002.

10. Takahashi, S., Inaguma, S., Cho, YM., Imaida, K., Wang, J., Fujiwara, O., Shirai, T.: Lack of mutation induction with exposure to 1.5 GHz electromagnetic near fields used for cellular phones in brains of Big Blue mice. Cancer Res, 62: 1956-1960, 2002.

11. Williams, GM., Iatropoulos, MJ., Jeffrey, AM., Shirai, T.: Protective effect of acetaminophen against colon cancer initiation effects of 3,2′-dimethyl-4-aminobiphenyl in rats. Eur J Cancer Prev, 11: 39-48, 2002.

12. Takahashi, S., Inaguma, S., Sakakibara, M., Cho, YM., Suzuki, S., Ikeda, Y., Cui, L., Shirai, T.: DNA methylation in the androgen receptor gene promotor region in rat prostate cancer, Prostate, 52: 82-88, 2002.

13. Inoue, T., Hioki, T., Hayashi, N., Takahashi, S., Shirai, T., Sugimura, Y.: Preoperative predictors of cancerous involvement of the neurovascular bundles in patients with localized prostate cancer. Int J Urol, 9: 47-53, 2002.

14. Tamano, S., Sano, M., Kawabe, M., Hagiwara, A., Nakamura, M., Imaida, K., Shirai, T.: Purple sweet potato color lacks tumor promoting or carcinogenic potential in a medium-term multi-organ carcinogenesis bioassay in male rats. Jpn J Fd Chem, 9: 22-29, 2002.

15. Ito, N.: Genetically modified foods: Hazard identification and risk assessment. Exp Toxicol Pathol, 54: 57-59, 2002.

16. Asamoto, M., Hokaiwado, N., Cho, YM., Shirai, T.: A transgenic rat model of prostate carcinogenesis, J Toxicol Pathol, 15: 191-196, 2002.

17. Fukushima, S., Wanibuchi, H., Morimura, K., Wei, M., Nakae, D., Konishi, Y., Tsuda, H., Uehara, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F., Wakabayashi, K., Totsuka, Y.: Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine. Jpn J Cancer Res, 93: 1076-1082, 2002.

18. Futakuchi, M., Ogawa, K., Sano, M., Tamano, S., Takeshita, F., Shirai, T.: Suppression of lung metastasis by aspirin but not indomethacin in an in vivo model of chemically induced hepatocellular carcinoma. Jpn J Cancer Res, 93: 1175-1181, 2002.

19. Shirai, T., Kato, K., Futakuchi, M., Takahashi, S., Suzuki, S., Imaida, K., Asamoto, M.: Organ differences in the enhancing potential of 2-amino-1-methy-6-phenylimidazo[4,5-b]pyridine on carcinogenicity in the prostate, colon and pancreas. Mutat Res, 506-507: 129-136, 2002.

20. Suzuki, S., Takahashi, S., Asamoto, M., Inaguma, S., Ogiso, T., Hirose, M., Shirai, T.: Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole – a CYP1A2 inducer. Cancer Lett, 185: 39-45, 2002.

21. Yoshino, H., Ichihara, T., Kawabe, M., Imai, N., Hagiwara, A., Asamoto, M., Shirai, T. Lack of significant alteration in the prostate or testis of F344 rat offspring after transplacental and lactational exposure to bisphenol A. J Toxicol Sci, 27: 433-439, 2002.

22. Hirose, M., Yamaguchi, T., Mizoguchi, Y., Akagi, K., Futakuchi, M., Shirai, T.: Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses. Cancer Lett, 188: 163-170, 2002.

23. Shirai, T., Asamoto, A., Takahashi, S., Imaida, K.: Diet and prostate cancer. Toxicology, 181-182: 89-94, 2002.

24. Yada, H., Hirose, M., Tamano, S., Kawabe, M., Sano, M., Takahashi, S., Futakuchi, M., Miki, T., Shirai, T.: Effects of antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model. Jpn J Cancer Res, 93: 1299-1307, 2002.

25. Fujiwara, H., Emi, M., Nagai, H., Nishimura, T., Konishi, N., Kubota, Y., Ichikawa, T., Takahashi, S., Shuin, T., Habuchi, T., Ogawa, O., Inoue, K., Skolnick, MH., Swensen, J., Camp, NJ., Tavtigian, SV.: Association of common missense changes in ELAC2 (HPC2) with prostate cancer in a Japanese case-control series. J Hum Genet, 47: 641-648, 2002.

1. Hagiwara, A., Miyashita, K., Yoshino, H., Sano, M., Tamano, S., Koda, T., Nakamura, M., Imaida, K., Shirai, T.: Four-week feeding study of Kusagi color, a natural blue food colorant, in F344 rats. Jpn J Fd Chem, 8: 174-179, 2001.

2. Ogawa, K., Hirose, M., Sugiura, S., Cui, L., Imaida, K., Ogiso, T., Shirai, T.: Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis. Nutr Cancer, 40: 134-139, 2001.

3. Tamano, S., Hagiwara, A., Kawabe, M., Sano, M., Tanaka, H, Imaida, K., Shirai, T., Ito, N.: Summary of test results of medium-term carcinogenesis bioassays targeting the liver or multi-organs. Toxicol Pathol, 29(Suppl.): 320-322, 2001.

4. Tamano, S., Hatahara, Y., Sano, M., Hagiwara, A., Nakamura, M., Washino, T., Imaida, K.: 13-week oral toxicity and 4-week recovery study of enzymatically modified isoquecitrin in F344/DuCrj rats Jpn. J Fd Chem., 8: 161-167, 2001.

5. Hokaiwado, N., Asamoto, M., Cho, YM., Imaida, K., Shirai, T.: Frequent c-Ha-ras gene mutations in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Lett, 163: 187-190, 2001.

6. Imaida, K., Tamano, S., Kato, K., Ikeda, Y., Asamoto, M., Takahashi, S., Nir, Z., Murakoshi, M., Nishino, H., Shirai, T.: Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis. Carcinogenesis, 22: 467-472, 2001.

7. Hagiwara A, Miyashita K, Nakanishi T, Sano M, Tamano S, Asai I, Nakamura M, Imaida K, Ito N, Shirai, T.: Lack of tumor promotion effects of carrageenan on 1,2-dimethylhydrazine-induced colorectal carcinogenesis in male F344 rats. J Toxicol Pathol, 14: 37-43, 2001.

8. Ogawa, K., Nakanishi, H., Takeshita, F., Futakuchi, M., Asamoto, M., Imaida, K., Tatematsu, M., Shirai, T.: Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice. Int J Cancer, 91: 797-802, 2001.

9. Watanabe, N., Okochi, E., Hirayama, Y., Shimada, Y., Yanagihara, K., Yoshida, MC., Takahashi, S., Mochizuki, M., Sugimura, T., Nagao, M., Ushijima, T.: Single nucleotide instability without microsatellite instability in rat mammary carcinomas. Cancer Res, 61: 2632-2640, 2001.

10. Thamavit, W., Pratoomtone, P., Kongtim, S., Shirai, T., Ito, N.: Inhibition by vitamin E of cholangiocarcinoma induction due to combined nitrite and aminopyrine. Asian Pac J Cancer Prev, 2: 69-70, 2001.

11. Kimoto, N., Hirose, M., Futakuchi, M., Iwata, T., Kasai, M., Shirai, T.: Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats. Cancer Lett, 168: 15-21, 2001.

12. Hirose, M., Hoshiya, T., Mizoguchi, Y., Nakamura, A., Akagi, K., Shirai, T.: Green tea catechins enhance tumor development in the colon without effects in the lung or thyroid after pretreatment with 1,2-dimethylhydrazine or 2,2′-dihydroxy-di-n-propylnitrosamine in male F344 rats. Cancer Lett, 168: 23-29, 2001.

13. Hagiwara, A., Takesada, Y., Tanaka, H., Tamano, S., Hirose, M., Ito, N., Shirai, T.: Dose-dependent induction of glandular stomach preneoplastic and neoplastic lesions in male F344 rats treated with catechol chronically. Toxicol Pathol, 29: 180-186, 2001.

14. Tatsura, H., Ogawa, K., Sakata, T., Okamura, T.: A nested variant of transitional cell carcinoma of the urinary bladder: a case report. Jpn J Clin Oncol, 31: 287-289, 2001.

15. Asamoto, M., Hokaiwado, N., Cho, YM., Takahashi, S., Ikeda, Y., Imaida, K., Shirai, T.: Prostate carcinomas developing in transgenic rats with SV40 T antigen expression under probasin promoter control are strictly androgen dependent. Cancer Res, 61: 4693-4700, 2001.

16. Asamoto, M., Hokaiwado, N., Cho, YM., Ikeda, Y., Takahashi, S., Shirai, T. : Metastasizing neuroblastomas from taste buds in rats transgenic for the simian virus 40 large T antigen under control of the probasin gene promoter. Toxicol Pathol, 29: 363-368, 2001.

17. Imaida, K., Sano, M., Tamano, S., Asamoto, M., Ogawa, K., Futakuchi, M., Shirai, T.: Organ dependent enhancement of rat 3,2′-dimethyl-4-aminobiphenyl (DMAB) carcinogenesis by 2-amino-1-methyl-6-phenyl- imidazo[4,5-b]pyridine (PhIP): positive effects on the intestine but not the prostate. Carcinogenesis, 22: 1295-1299, 2001.

18. Hagiwara, A., Miyashita, K., Nakanishi, T., Sano, M., Tamano, S., Kadota, T., Koda, T., Nakamura, M., Imaida, K., Ito, N., Shirai, T.: Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine. Cancer Lett, 171: 17-25, 2001.

19. Shimizu, K., Iida, M., Takahashi, S.: Hodgkin’s disease producing granulocyte colony stimulating factor. Am J Hematol, 68: 134, 2001.

20. Mori, T., Imaida, K., Tamano, S., Sano, M., Takahashi, S., Asamoto, M., Takeshita, M., Ueda, H., Shirai, T.: Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2′-dimethyl-4-aminobiphenyl. Jpn J Cancer Res, 92: 1026-1033, 2001.

21. Imaida, K., Kuzutani, K., Wang, J., Fujiwara, O., Ogiso, T., Kato, K., Shirai, T.: Lack of promotion of 7,12-dimethhylbenz[a]anthracene-initiated mouse skin carcinogenesis by 1.5 GHz electromagnetic near fields. Carcinogenesis, 22: 1837-1841, 2001.

22. Ito, N.: Genetically modified foods – hazard identification and risk assessment. J Toxicol Pathol, 14: 327-329, 2001.

1. Ogawa, K., Kimoto, N., Asamoto, M., Nakanishi, M., Takahashi, S., Shirai, T.: Aberrant expression of p27Kip1 is associated with malignant transformation of the rat urinary bladder epithelium. Carcinogenesis, 21: 117-121, 2000.

2. Zhang, R., Suzuki, T., Takahashi, S., Yoshida, A., Kawaguchi, H., Maruyama, H., Yabu, Y., Fu, J., Shirai, T., Ohta, N.: Cloning and molecular characterization of calpain, a calcium-activated neutral proteinase, from different strains of Schistosoma japonicum. Parasitol Int, 48: 233-242, 2000.

3. Cui, L., Takahashi, S., Tada, M., Kato, K., Yamada, Y., Kohri, K., Shirai, T.: Immunohistochemical detection of carcinogen-DNA adducts in normal human prostate tissues transplanted into the subcutis of athymic nude mice: Results with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 3,2′-dimethyl-4-aminobiphenyl (DMAB) and relation to cytochrome P450s and N-acetyltransferase activity. Jpn J Cancer Res, 91: 52-58, 2000.

4. Imaida, K., Ogawa, K., Takahashi, S., Ito, T., Yamaguchi, T., Totsuka, Y., Wakabayashi, K., Tanaka, K., Ito, N., Shirai, T.: Delay of DNA-adduct repair and severe toxicity in xeroderma pigmentosum group A gene (XPA) deficient mice treated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Cancer Lett, 150: 63-69, 2000.

5. Yaono, M., Tamano, S., Mori, T., Kato, K., Imaida, K., Asamoto, M., Shirai, T.: Lobe specific effects of testosterone and estrogen on 3,2′-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis. Cancer Lett, 150: 33-40, 2000.

6. Takahashi, S., Ikeda, Y., Kimoto, N., Okochi, E., Cui, L., Nagao, M., Ushijima, T., Shirai, T.: Mutation induction by mechanical irritation caused by uracil-induced urolithiasis in Big Blue rats. Mutat Res, 447: 275-280, 2000.

7. Maruyama, H., Osada, Y., Yoshida, A., Futakuchi, M., Kawaguchi, H., Zhang, R., Fu, J., Shirai, T., Kojima, S., Ohta, N.: Protective mechanisms against the intestinal nematode Strongyloides venezuelensis in Schistosoma japonicum-infected mice. Parasite Immunol, 22: 279-286, 2000.

8. Ito, N., Imaida, K., Asamoto, M., Shirai, T.: Early detection of carcinogenic substances and modifiers in rats. Mutat Res, 462: 209-217, 2000.

9. Shirai, T., Takahashi, S., Cui, L., Futakuchi, M., Kato, K., Tamano, S., Imaida, K.: Experimental prostate carcinogenesis—rodent models. Mutat Res, 462: 219-226, 2000.

10. Imaida, K., Hagiwara, A., Yoshino, H., Tamano, S., Sano, M., Futakuchi, M., Ogawa, K., Asamoto, M., Shirai, T.: Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure. Cancer Lett, 155: 105-114, 2000.

11. Archer, CL., Morse, P., Jones, RF., Shirai, T., Haas, GP., Wang, CY.: Carcinogenicity of the N-hydroxy derivative of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 2-amino-3,8-dimethylimidazo[4,5-f]- quinoxaline and 3,2′-dimethyl-4-aminobiphenyl in the rat. Cancer Lett, 155: 55-60, 2000.

12. Hirose, M., Yamaguchi, T., Cui, L., Kimoto, N., Futakuchi, M., Kono, T., Nishibe, S., Shirai, T.: Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats. Cancer Lett, 155: 79-88, 2000.

13. Kato, K., Takahashi, S., Cui, L., Toda, T., Suzuki, S., Futakuchi, M., Sugiura, S., Shirai, T.: Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis. Jpn J Cancer Res, 91: 786-791, 2000.

14. Takahashi, S., Ikeda, Y., Orita, S., Sakakibara, M., Kimoto, N., Suzuki, S., Imaida, K., Shirai, T.: Enhancing effects of 2-amino-4,5-diphenylthiazole-induced polycystic kidneys on renal carcinogenesis in rats treated with dimethylnitrosamine. Toxicol Appl Pharmacol, 167: 12-17, 2000.

15. Akaza, H., Tsukamoto, S., Morita, T., Yamauchi, A., Onozawa, M., Shimazui, T., Ideyama, Y., Shirai, T.: Promoting effects of antiandrogenic agents on rat ventral prostate carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl (DMAB). Prostate Cancer Prostatic Dis, 3: 115-119, 2000.

16. Tiwawech, D., Hirose, M., Futakuchi, M., Cui, L., Thamavit, W., Ito, N., Shirai, T.: Enhancing effects of Thai edible plants on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay. Cancer Lett, 158: 195-201, 2000.

17. Cohen, S.M., Shirai, T., Steineck, G.: Epidemiology and etiology of premalignant and malignant urothelial changes. Scand J Urol Nephrol Suppl, 205: 105-115, 2000.

18. Kawabe, M., Cui, L., Kimoto, N., Sano, M., Hirose, M., Shirai, T.: Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation. Nutr Cancer, 37: 179-186, 2000.

19. Shirai, T., Imaida, K., Ito, N. Prostate. In: Nagao, M. and Sugimura, T. eds, Food Born Carcinogens — heterocyclic amines. pp270-274, John Wiley & Sons, Ltd, 2000.

20. Imaida, K., Shirai, T., Ito, N. Degenerative Changes. In: Nagao, M. and Sugimura, T. eds, Food Born Carcinogens — heterocyclic amines, pp275-284, John Wiley & Sons, Ltd, 2000.

1. Iwasaki, S., Kato, K., Mori, T., Takahashi, S., Futakuchi, M., Shirai, T.: Development of androgen-independent carcinomas from androgen-dependent preneoplastic lesions in the male accessory sex organs of rats treated with 3,2′-dimethyl-4-aminobiphenyl and testosterone propionate. Jpn J Cancer Res, 90: 23-30, 1999.

2. Moore, MA., Tsuda, H., Tamano, S., Hagiwara, A., Imaida, K., Shirai, T., Ito, N.: Marriage of a medium-term liver model to surrogate markers — a practical approach for risk and benefit assessment. Toxicol Pathol, 27: 237-242, 1999.

3. Hagiwara, A., Murai, T., Yoshino, H., Goshima, H., Mori, S., Takashima, A., Shirai, T., Fukushima, S.: Hepatocarcinogenic activity of N-butyl-N-(4-hydroxybutyl)nitrosamine in rats is not modified by sodium L-ascorbate. Teratog Carcinog Mutagen, 19: 33-42, 1999.

4. Hagiwara, A., Boonyaphiphat, P., Tanaka, H., Kawabe, M., Tamano, S., Kaneko, H., Matsui, M., Hirose, M., Ito, N., Shirai, T.: Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants -tocopherol and n-tritriacontane-16,18-dione, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)- induced mammary and colonic carcinogenesis in female F344 rats. Jpn J Cancer Res, 90: 399-405, 1999.

5. Ogawa, K., Tsuda, H., Shirai, T., Ogiso, T., Wakabayashi, K., Dalgard, DW., Thorgeirsson, UP., Thorgeirsson, SS., Adamson, RH., Sugimura, T.: Lack of carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in cynomolgus monkeys. Jpn J Cancer Res, 90: 622-628, 1999.

6. Hirose, M., Hakoi, K., Takahashi, S., Hoshiya, T., Akagi, K., Cui, L., Saito, K., Kaneko, H., Shirai, T.: Sequential morphological and biological changes in the glandular stomach induced by oral administration of catechol to male F344 rats. Toxicol Pathol, 27: 448-455, 1999.

7. Sano, M., Hagiwara, A., Tamano, S., Hasegawa, R., Imaida, K., Ito, N., Shirai, T.: Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation. J Toxicol Sci, 24: 177-186, 1999.

8. Kimura, S., Kawabe, M., Ward, JM., Morishima, H., Kadlubar, FF., Hammons, GJ., Fernandez-Salguero, P., Gonzalez, FJ.: CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice. Carcinogenesis, 20: 1825-1830, 1999.

9. Richie, JP., Bono, A., Denis, LJ., Jewett, MA., Kakizoe, T., Kotake, T., Shirai, T., Ten Kate, FJ.: Tumor, nodes, metastasis (TNM) classification of bladder cancer., Urol Oncol, 4: 90-93, 1998.

10. Shirai, T.: Commentary: Oncosis and apoptosis: Two faces of necrosis in a new proposal to clear up the confusion regarding cell death. Toxicol Pathol, 27: 495-496, 1999.

11. Shirai, T., Cui, L., Takahashi, S., Futakuchi, M., Asamoto, M., Kato, K., Ito, N.: Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate. Cancer Lett, 143: 217-221, 1999.

12. Hirose, M., Takahashi, S., Ogawa, K., Futakuchi, M., Shirai, T., Shibutani, M., Uneyama, C., Toyoda, K., Iwata, H.: Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats. Cancer Lett, 143: 173-178, 1999.

13. Okochi, E., Watanabe, N., Shimada, Y., Takahashi, S., Wakazono, K., Shirai, T., Sugimura, T., Nagao, M., Ushijima, T.: Preferential induction of guanine deletion at 5′-GGGA-3′ in rat mammary glands by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Carcinogenesis, 20: 1933-1938, 1999.

14. Futakuchi, M., Hirose, M., Ogiso, T., Kato, K., Sano, M., Ogawa, K., Shirai, T.: Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model. Jpn J Cancer Res, 90: 1196-1202, 1999.

15. Ikeda, Y., Takahashi, S., Kimura, J., Cho, YM., Imaida, K., Shirai, S., Shirai, T.: Anophthalmia in litters of female rats treated with the food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Toxicol Pathol, 27: 628-631, 1999.

16. Hirose, M., Fukushima, S., Imaida, K., Ito, N., Shirai, T.: Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis. Anticancer Res, 19: 3665-3670, 1999.

17. Ogawa, K., St. John, M., de Oliveira, ML., Arnold, L., Shirai, T., Sun, TT., Cohen, SM.: Comparison of uroplakin expression during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats and mice. Toxicol Pathol, 27: 645-651, 1999.

18. Hirose, M., Takahashi, S., Ogawa, K., Futakuchi, M., Shirai, T.: Phenolics: Blocking agents for heterocyclic amine-induced carcinogenesis. Fd Chem Toxicol, 37: 985-992, 1999.

19. Ogawa, K., Johansson, SL., Cohen, SM.: Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. Am J Pathol, 155: 1047-1050, 1999.

20. Shirai, T., Hirose, M., Ito, N. : Medium-term bioassays in rats for rapid detection of the carcinogenic potential of chemicals. In: McGregor, DB., Rice, JM., Venitt, D. (eds.), The use of short- and medium-term tests for carcinogens and data on genetic effects in carcinogenic hazard evaluation. IARC Scientific Publications No. 146, pp251-272. International Agency for Research on Cancer, Lyon, 1999.

21. Hirose, M., Ito, N.: Forestomach and glandular stomach carcinogenesis. In: Kitchin, KT. (ed.) Carcinogenicity — Testing, predicting, and interpreting chemical effects. pp467-497. Marcel Dekker, Inc., New York, 1999.

22. Thamavit, W., Shirai, T., Ito, N.: Liver flukes and biliary cancer. In: Parsonnet, J. (ed.) Microbes and malignancy — Infection as a cause of human cancers. pp346-371. Oxford University Press, New York, Oxford, 1999.

1. Shirai, T., Takahashi, S., Cui, L., Yamada, Y., Tada, M., Kadlubar, FF., Ito, N.: Use of polyclonal antibodies against carcinogen-DNA adducts in analysis of carcinogenesis. Toxicol Lett, 102-103: 441-446, 1998.

2. Cui, L., Mori, T., Takahashi, S., Imaida, K., Akagi, K., Yada, H., Yaono, M., Shirai, T.: Slight promotion effects of intermittent administration of testosterone propionate and/or diethylstilbestrol on 3,2′-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis. Cancer Lett, 122: 195-199, 1998.

3. Tsukamoto, S., Akaza, H., Onozawa, M., Shirai, T., Ideyama, Y.: A five-alpha reductase inhibitor or an antiandrogen prevents the progression of microscopic prostate carcinoma to macroscopic carcinoma in rats. Cancer, 82: 531-537, 1998.

4. Hasegawa, R., Futakuchi, M., Mizoguchi, Y., Yamaguchi, T., Shirai, T., Ito, N., Lijinsky, W.: Studies of initiation and promotion of carcinogenesis by N-nitroso compounds. Cancer Lett, 123: 185-191, 1998.

5. Imaida, K., Taki, M., Yamaguchi, T., Ito, T., Watanabe, S., Wake, K., Aimoto, A., Kamimura, Y., Ito, N., Shirai, T.: Lack of promoting effects of the electromagnetic near-field used for cellular phones (929.2 MHz) on rat liver carcinogenesis in a medium-term liver bioassay. Carcinogenesis, 19: 311-314, 1998.

6. Wada, S., Hirose, M., Shichino, Y., Ozaki, K., Hoshiya, T., Kato, K., Shirai, T.: Effects of catechol, sodium chloride and ethanol either alone or in combination on gastric carcinogenesis in rats pretreated with N-methyl-N’-nitro-N-nitrosoguanidine. Cancer Lett, 123: 127-134, 1998.

7. Hirose, M., Takesada, Y., Tanaka, H., Tamano, S., Kato, T., Shirai, T.: Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model. Carcinogenesis, 19: 207-212, 1998.

8. Ogawa, K., Iwasaki, S., Esumi, H., Fukushima, S., Shirai, T.: Modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) of 3,2′-dimethyl-4-aminobiphenyl (DMAB)-induced rat pancreatic and intestinal tumorigenesis. Cancer Lett, 124: 31-37, 1998.

9. Takahashi, S., Hirose, M., Tamano, S., Ozaki, M., Orita, S., Ito, T., Takeuchi, M., Ochi, H., Fukada, S., Kasai, H., Shirai, T.: Immunohistochemical detection of 8-hydroxy-2′-deoxyguanosine in paraffin-embedded sections of rat liver after carbon tetrachloride treatment. Toxicol Pathol, 26: 247-252, 1998.

10. Kato, K., Takahashi, S., Mori, T., Futakuchi, M., Cui, L., Ito, N., Shirai, T.: Establishment of transplantable rat prostate carcinomas from primary lesions induced by 3,2′-dimethyl-4-aminobiphenyl and testosterone. J Toxicol Pathol, 11: 27-32, 1998.

11. Futakuchi, M., Hirose, M., Miki, T., Tanaka, H., Ozaki, M., Shirai, T.: Inhibition of DMBA-initiated rat mammary tumour development by 1-O-hexyl-2,3,5-trimethylhydroquinone, phenylethyl isothiocyanate, and novel synthetic ascorbic acid derivatives. Eur J Cancer Prev, 7: 153-159, 1998.

12. Kato, T., Hirose, M., Takahashi, S., Hasegawa, R., Kohno, T., Nishibe, S., Kato, K., Shirai, T.: Effects of the lignan, arctiin, on 17-β ethinyl estradiol promotion of preneoplastic liver cell foci development in rats. Anticancer Res, 18: 1053-1058, 1998.

13. Mizoguchi, Y., Hirose, M., Yamaguchi, T., Boonyaphiphat, P., Miki, T., Shirai, T.: Dose dependence of 1-O-hexyl-2,3,5-trimethylhydroquinone promotion of forestomach carcinogenesis in rats pretreated with N-ethylnitrosourethane., Jpn J Cancer Res, 89: 475-480, 1998.

14. Hirose, M., Futakuchi, M., Tanaka, H., Orita, SI., Ito, T., Miki, T., Shirai, T.: Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: results of extended and combination treatment experiments. Eur J Cancer Prev, 7: 61-67, 1998.

15. Ogawa, K., Futakuchi, M., Hirose, M., Boonyaphiphat, P., Mizoguchi, Y., Miki, T., Shirai, T.: Stage and organ dependent effects of 1-O-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, n-heptadecane-8,10- dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis model. Int J Cancer, 76: 851-856, 1998.

16. Tamano, S., Hirose, M., Tanaka, H., Hagiwara, A., Shirai, T.: Variation in susceptibility to the induction of forestomach tumours by butylated hydroxyanisole among rats of different strains. Fd Chem Toxicol, 36: 299-304, 1998.

17. Hirose, M., Ito, T., Takahashi, S., Ozaki, M., Ogiso, T., Nihro, Y., Miki, T., Shirai, T.: Prevention by synthetic phenolic antioxidants of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)- or activated MeIQx-induced mutagenesis and MeIQx-induced rat hepatocarcinogenesis, and role of antioxidant activity in the prevention of carcinogenesis. Eur J Cancer Prev, 7: 233-241, 1998.

18. Asamoto, M., Hori, T., Baba-Toriyama, H., Sano, M., Takahashi, S., Tsuda, H., Shirai, T.: p16 gene overexpression in mouse bladder carcinomas. Cancer Lett, 127: 9-13, 1998.

19. Hirose, M., Yamaguchi, T., Kimoto, N., Ogawa, K., Futakuchi, M., Sano, M., Shirai, T.: Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats. Int J Cancer, 77: 773-777, 1998.

20. Lucia, MS., Bostwick, DG., Bosland, M., Cockett, AT., Knapp, DW., Leav, I., Pollard, M., Rinker-Schaeffer, C., Shirai, T., Watkins, BA.: Workgroup I: Rodent models of prostate cancer. Prostate, 36: 49-55, 1998.

21. Takahashi, S., Kimoto, N., Orita, S., Cui, L., Sakakibara, M., Shirai, T.: Relationship between CD44 expression and differentiation of human prostate adenocarcinomas. Cancer Lett, 129: 97-102, 1998.

22. Yamada, Y., Tozawa, K., Cui, L., Takahashi, S., Shirai, T., Kohri, K.: Characteristics of nonneoplastic human prostate tissue transplanted into nude mice. Prostate, 37: 109-115, 1998.

23. Kitano, M., Ichihara, T., Matsuda, T., Wanibuchi, H., Tamano, S., Hagiwara, A., Imaoka, S., Funae, Y., Shirai, T., Fukushima, S.: Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat. Carcinogenesis, 19: 1475-1480, 1998.

24. Takahashi, S., Tamano, S., Hirose, M., Kimoto, N., Ikeda, Y., Sakakibara, M., Tada, M., Kadlubar, FF., Ito, N., Shirai, T.: Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): Detection in paraffin-embedded sections and tissue distribution. Cancer Res, 58: 4307-4313, 1998.

25. Zhang, R., Takahashi, S., Orita, S., Yoshida, A., Maruyama, H., Shirai, T., Ohta, N.: p53 gene mutations in rectal cancer associated with schistosomiasis japonica in Chinese patients. Cancer Lett, 131: 215-221, 1998.

26. Imaida, K., Taki, M., Watanabe, S., Kamimura, Y., Ito, T., Yamaguchi, T., Ito, N., Shirai, T.: The 1.5 GHz electromagnetic near-field used for cellular phones does not promote rat liver carcinogenesis in a medium-term liver bioassay. Jpn J Cancer Res, 89: 995-1002, 1998.

27. Ito, N., Imaida, K., Tamano, S., Hagiwara, A., Shirai, T.: Medium-term bioassays as alternative carcinogenicity test. J Toxicol Sci, 23 Suppl 2: 103-106, 1998.

28. Hashimoto, Y., Suzuki, T., Shimizu, Y., Otobe, Y., Nakamura, T., Nakamura, Y., Tanaka, M., Ito, K., Ueda, N., Hayashi, S., Manabe, T., Futakuchi, M., Shirai, T.: ABO-incompatible living related liver transplantation for fulminant hepatitis: report of a successful pediatric case with long-term follow-up. Transplant Proc, 30: 3510-3512, 1998.

29. Ito, N., Imaida, K., Hirose, M., Shirai, T.: Medium-term bioassays for carcinogenicity of chemical mixtures. Environ Health Perspect, 106 Suppl 6: 1331-1336, 1998.

30. Bosland, MC., Tuomari, DL., Elwell, MR., Shirai, T., Ward, JM., McConnel, RF.: Proliferative lesions of the prostate and other accessory sex glands in male rats. In: Guides for Toxicologic Pathology, pp1-20. STP/ARP/AFIP, Washington, DC, 1998.

31. Ito, N., Imaida, K., Hagiwara, A., Tamano, S., Shirai, T.: Effects of ingesting a combination of 20 or 40 pesticides at ADI levels on carcinogenesis in rats. In: Reviews in Toxicology 2, pp85-92, IOS Press, 1998.

1. Shirai, T., Sano, M., Tamano, S., Takahashi, S., Hirose, M., Futakuchi, M., Hasegawa, R., Imaida, K., Matsumoto, K., Wakabayashi, K., Sugimura, T., Ito, N.: The prostate: A target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods. Cancer Res, 57: 195-198, 1997.

2. Masui, T., Nakanishi, H., Inada, K., Imai, T., Mizoguchi, Y., Yada, H., Futakuchi, M., Shirai, T., Tatematsu, M.: Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes. Cancer Lett, 112: 33-45, 1997.

3. Hirose, M., Mizoguchi, Y., Yaono, M., Tanaka, H., Yamaguchi, T., Shirai, T.: Effects of green tea catechins on the progression or late promotion stage of mammary gland carcinogenesis in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz(a)anthracene. Cancer Lett, 112: 141-147, 1997.

4. Kim, DJ., Han, BS., Ahn, B., Hasegawa, R., Shirai, T., Ito, N., Tsuda, H.: Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model. Carcinogenesis, 18: 377-381, 1997.

5. Takaba, K., Hirose, M., Yoshida, Y., Kimura, J., Ito, N., Shirai, T.: Effects of n-tritriacontane-16,18-dione, curcumin, chlorophyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model. Cancer Lett, 113: 39-46, 1997.

6. Asamoto, M., Iwahori, Y., Okamura, T., Shirai, T., Tsuda, H.: Decreased expression of the p16/MTS1 gene without mutation is frequent in human urinary bladder carcinomas. Jpn J Clin Oncol, 27: 22-25, 1997.

7. Saeki, K., Kadoi, M., Kawazoe, Y., Futakuchi, M., Tiwawech, D., Shirai, T.: Modification of the carcinogenic potency of quinoline, a hepatocarcinogen, by fluorine atom substitution: evaluation of carcinogenicity by a medium-term assay. Biol Pharm Bull, 20: 40-43, 1997.

8. Imaida, K., Hasegawa, R., Kato, T., Futakuchi, M., Takahashi, S., Ogawa, K., Asamoto, M., Yamamoto, T., Suzuki, K., Inagaki, T., Shinagawa, N., Shirai, T.: Clinicopathological analysis on cancers of autopsy cases in a geriatric hospital. Pathol Int, 47: 293-300, 1997.

9. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T., Tamano, S., Hagiwara, A.: Medium-term rat liver bioassay for rapid detection of hepatocarcinogenic substances. J Toxicol Pathol, 10: 1-11, 1997.

10. Yada, H., Hasegawa, R., Hirose, M., Shirai, T., Ito, N.: Effects of verapamil on PhIP-induced tumorigenesis in F344 rats. J Toxicol Pathol, 10: 45-49, 1997.

11. Kawabe, M., Shibata, MA., Sano, M., Takesada, Y., Tamano, S., Ito, N., Shirai, T.: Decrease of prostaglandin E2 and 5-bromo-2′-deoxyuridine labeling but not prostate tumor development by indomethacin treatment of rats given 3,2′-dimethyl-4-aminobiphenyl and testosterone propionate. Jpn J Cancer Res, 88: 350-355, 1997.

12. Miyata, E., Kawabe, M., Sano, M., Takesada, Y., Takahashi, S., Shirai, T.: Effects of tamoxifen, an antiestrogen, on rat prostate carcinogenesis by 3,2′-dimethyl-4-aminobiphenyl and testosterone do not support an estrogen role in testosterone promotion. Prostate, 31: 9-13, 1997.

13. Ozaki, M., Shibata, MA., Takahashi, S., Orita, S., Kawabe, M., Shirai, T.: Lack of involvement of p53 gene mutations in N-methyl-N-nitrosourea-induced bladder tumor progression in N-butyl-N-(4-hydroxybutyl)- nitrosamine-treated rats and no suppression by indomethacin. Cancer Lett, 115: 249-255, 1997.

14. Tanaka, H., Hirose, M., Kawabe, M., Sano, M., Takesada, Y., Hagiwara, A., Shirai, T.: Post-initiation inhibitory effects of green tea catechins on 7,12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis in female Sprague-Dawley rats. Cancer Lett, 116: 47-52, 1997.

15. Ito, N., Hasegawa, R., Imaida, K., Tamano, S., Hagiwara, A., Hirose, M., Shirai, T.: Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat. Mutat Res, 376: 107-114, 1997.

16. Shirai, T.: A medium-term rat liver bioassay as a rapid In vivo test for carcinogenic potential: A historical review of model development and summary of results from 291 tests. Toxicol Pathol, 25: 453-460, 1997.

17. Shirai, T.: Society of Toxicologic Pathologists — Japanese Society of Toxicologic Pathology: a long and fruitful partnership. Toxicol Pathol, 25: 668-669, 1997.

18. Hirose, M., Shirai, T., Lee, MS., Wang, CY., King, CM.: Carcinogenicity of the N-acyl derivatives of N-hydroxy-trans-4-aminostilbene in CD rats. Chem Biol Interact, 106: 123-132, 1997.

19. Pfau, W., Schulze, C., Shirai, T., Hasegawa, R., Brockstedt, U.: Identification of the major hepatic DNA adduct formed by the food mutagen 2-amino-9H-pyrido[2,3-b]indole (AαC). Chem Res Toxicol, 10: 1192-1197, 1997.

20. Pfau, W., Brockstedt, U., Shirai, T., Ito, N., Marquardt, H.: Pancreatic DNA adducts formed in vitro and in vivo by the food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP) and 2-amino-3-methyl- 9H-pyrido[2,3-b]indole (MeAaC). Mutat Res, 378: 13-22, 1997.

21. Hagiwara, A., Kawabe, M., Tanaka, H., Kokubo, Y., Sano, M., Tamano, S., Kadota, T., Nakamura, M., Imaida, K.: Two different constituents of madder colors lack tumor promoting or carcinogenic potential in a medium-term multi-organ carcinogenesis bioassay in rats. Jpn J Fd Chem, 4: 99-106, 1997.

22. Fukushima, S., Takada, N., Takahashi, S., Wanibuchi, H.: Development of medium-term bioassays for detection of chemopreventive agents. In: Ohigashi, H. et al. (eds.), Food factors for cancer prevention. pp88-91, Springer-Verlag Tokyo, Tokyo, 1997.

23. Hirose, M., Hasegawa, R., Futakuchi, M., Tanaka, H., Miki, T., Kaneko, H., Shirai, T.: Prevention of chemically induced rat carcinogenesis by antioxidants: Focus on HTHQ. I In: Ohigashi, H. et al. (eds.), Food factors for cancer prevention. pp82-87, Springer-Verlag Tokyo, Tokyo, 1997.

24. Shirai, T., Takahashi, S., Tamano, S.: Preneoplasia and neoplasia of the rat male genital tract. In: Bannasch, P. & Gössner, W. (eds.), Pathology of Neoplasia and Preneoplasia in Rodents, Vol. 2, pp141-162, Schattauer, Stuttgart, Germany, 1997.

1. Takahashi, S., Hall, J., Montesano, R.: Temporal cell-type-specific mRNA expression of O6-methylguanine-DNA methyltransferases in liver of rats treated with dimethylnitrosamine. Am J Pathol, 148: 497-507, 1996.

2. Yaono, M., Hasegawa, R., Kato, K., Kimura, J., Cui, L., Tada, M., Shirai, T.: Immunohistochemical demonstration of 3,2′-dimethyl-4-aminobiphenyl DNA adduct formation in various organs of Syrian golden hamsters. Cancer Lett, 98: 145-149, 1996.

3. Cui, L., Hasegawa, R., Ogawa, K., Yamada, Y., Takahashi, S., Shirai, T.: Histopathological analysis of invasive bladder carcinomas induced by 3,2′-dimethyl-4-aminobiphenyl in hamsters. Jpn J Cancer Res, 87: 37-43, 1996.

4. Ogawa, K., Imaida, K., Masui, T., Kawabe, M., Hasegawa, R., Kato, K., Ito, N., Shirai, T.: Chemically induced lung and forestomach neoplasias in transgenic mice carry mutant forms of the human c-Ha-ras transgene. Carcinogenesis, 17: 341-345, 1996.

5. Totsuka, Y., Fukutome, K., Takahashi, M., Takahashi, S., Tada, A., Sugimura, T., Wakabayashi, K.: Presence of N2-(deoxyguanosin-8-yl)-2-amino3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues. Carcinogenesis, 17: 1029-1034, 1996.

6. Chemin, I., Takahashi, S., Belloc, C., Lang, MA., Ando, K., Guidotti, LG., Chisari, FV., Wild, CP.: Differential induction of carcinogen metabolizing enzymes in a transgenic mouse model of fulminant hepatitis. Hepatology, 24: 649-656, 1996.

7. Kimura, J., Hasegawa, R., Yaono, M., Kato, T., Wakabayashi, K., Sugimura, T., Ito, N., Shirai, T.: Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in Sprague-Dawley rats. Cancer Lett, 101: 73-78, 1996.

8. Kato, T., Hasegawa, R., Nakae, D., Hirose, M., Yaono, M., Cui, L., Kobayashi, Y., Konishi, Y., Ito, N., Shirai, T.: Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels., Jpn J Cancer Res, 87: 127-133, 1996.

9. Wada, S., Kato, T., Mutai, M., Ozaki, K., Yamaguchi, S., Kim, DJ., Baba-Toriyama, H., Asamoto, M., Ito, N., Tsuda, H.: Modifying influence of swine serum-induced liver fibrosis on development of preneoplastic lesions in rat liver. Jpn J Cancer Res, 87: 240-246, 1996.

10. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T.: Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents. Exp Toxicol Pathol, 48: 113-119, 1996.

11. Tanaka, H., Hasegawa, R., Takesada, Y., Ogiso, T., Hirose, M., Shirai, T.: Effects of carbamate insecticides in a rat medium-term bioassay for hepatocarcinogens. J Toxicol Environ Health, 47: 493-498, 1996.

12. Kawabe, M., Takesada, Y., Tamano, S., Hagiwara, A., Ito, N., Shirai, T.: Subchronic toxicity study of L-isoleucine in F344 rats. J Toxicol Environ Health, 47: 499-508, 1996.

13. Wild, CP., Hasegawa, R., Barraud, L., Chutimataewin, S., Chapot, B., Ito, N., Montesano, R.: Aflatoxin-albumin adducts: A basis for comparative carcinogenesis between animals and humans. Cancer Epidemiol Biomarkers Prev, 5: 179-189, 1996.

14. Futakuchi, M., Hasegawa, R., Yamamoto, A., Cui, L., Ogiso, T., Ito, N., Shirai, T.: Low susceptibility of the spontaneously hypertensive rat (SHR) to quinoline-induction of hepatic hemangioendothelial sarcomas. Cancer Lett, 104: 37-41, 1996.

15. Sano, M., Miyata, E., Tamano, S., Hagiwara, A., Ito, N., Shirai, T.: Lack of carcinogenicity of tamarind seed polysaccharide in B6C3F1 mice. Fd Chem Toxicol, 34: 463-467, 1996.

16. Mori, T., Cui, L., Kato, K., Takahashi, S., Imaida, K., Iwasaki, S., Ito, N., Shirai, T.: Direct effects of testosterone, dihydrotestosterone and estrogen on 3,2′-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in castrated F344 rats. Jpn J Cancer Res, 87: 570-574, 1996.

17. Kimura, J., Takahashi, S., Ogiso, T., Yoshida, Y., Akagi, K., Hasegawa, R., Kurata, M., Hirose, M., Shirai, T.: Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model. Jpn J Cancer Res, 87: 589-594, 1996.

18. Cui, L., Hasegawa, R., Ogawa, K., Futakuchi, M., Shirai, T.: Enhancing effects of high-fat diet on 3,2′-dimethyl-4-aminobiphenyl urinary bladder carcinogenesis in the hamster. J Toxicol Pathol, 9: 169-174, 1996.

19. Takahashi, S., Imaida, K., Shirai, T., Wakabayashi, K., Nagao, M., Sugimura, T., Ito, N.: Chronic administration of the mutagenic heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces cardiac damage with characteristic mitochondrial changes in Fischer rats. Toxicol Pathol, 24: 273-277, 1996.

20. Hagiwara, A., Miyata, E., Tamano, S., Shibata, MA., Sugiura, S., Inoue, M., Hirose, M.: Non-carcinogenicity of 2,2′-[(4-aminophenyl)imino]bisethanol sulfate in a long-term feeding study in Fischer 344 rats. Fd Chem Toxicol, 34: 537-546, 1996.

21. Thamavit, W., Tiwawech, D., Moore, MA., Ito, N., Shirai, T.: Equivocal evidence of complete carcinogenicity after repeated infection of Syrian hamsters with Opisthorchis viverrini. Toxicol Pathol, 24: 493-497, 1996.

22. Futakuchi, M., Lijinsky, W., Hasegawa, R., Hirose, M., Ito, N., Shirai, T.: Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat. Cancer Lett, 106: 263-269, 1996.

23. Hasegawa, R., Shirai, T., Ito, N.: Synergism in hepatocarcinogenesis induced by heterocyclic amines in rats. J Toxicol Pathol, 9: 241-248, 1996.

24. Tamano, S., Hagiwara, A., Tanaka, H., Kawabe, M., Sano, M., Takahashi, S., Shirai, T.: Histopathological evaluation of spontaneous hepatocellular tumors in B6C3F1 hybrid mice. J Toxicol Pathol, 9: 263-271, 1996.

25. Tamano, S., Rehm, S., Waalkes, MP., Ward, JM.: High incidence and histogenesis of seminal vesicle adenocarcinoma and lower incidence of prostate carcinomas in the Lobund-Wistar prostate cancer rat model using N-nitrosomethylurea and testosterone. Vet Pathol, 33: 557-567, 1996.

26. Imaida, K., Hagiwara, A., Yada, H., Masui, T., Hasegawa, R., Hirose, M., Sugimura, T., Ito, N., Shirai, T.: Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res, 87: 1116-1120, 1996.

27. Hasegawa, R., Yoshimura, I., Imaida, K., Ito, N., Shirai, T.: Analysis of synergism in hepatocarcinogenesis based on preneoplastic foci induction by 10 heterocyclic amines in the rat. Jpn J Cancer Res, 87: 1125-1133, 1996.

28. Hashimoto, Y., Asamoto, M., Futakuchi, M., Okamura, T., Kohri, K., Shirai, T.: Immunohistochemical demonstration of p53 protein nuclear accumulation in preneoplastic and neoplastic lesions of the human urinary bladder. J Urol Pathol, 5: 21-27, 1996.

29. Imaida, K., Fukushima, S.: Initiation-promotion model for assessment of carcinogenicity: Medium-term liver bioassay in rats for rapid detection of carcinogenic agents. J Toxicol Sci, 21: 483-487, 1996.

30. Tamano, S., Ward, JM., Diwan, BA., Keefer, LK., Weghorst, CM., Calvert, RJ., Henneman, JR., Ramljak, D., Rice, JM.: Histogenesis and the role of p53 and K-ras mutations in hepatocarcinogenesis by glyceryl trinitrate (nitroglycerin) in male F344 rats. Carcinogenesis, 17: 2477-2486, 1996.

31. Nakanishi, H., Takeuchi, S., Kato, K., Shimizu, S., Kobayashi, K., Tatematsu, M., Shirai, T.: Establishment and characterization of three androgen-independent, metastatic carcinoma cell lines from 3,2′-dimethyl-4-aminobiphenyl-induced prostatic tumors in F344 rats. Jpn J Cancer Res, 87: 1218-1226, 1996.

32. Kobayashi, K., Nakanishi, H., Inada, K., Fujimitsu, Y., Yamachika, T., Shirai, T., Tatematsu, M.: Growth characteristics in the initial stage of micrometastasis formation by bacterial lacZ gene-tagged rat prostatic adenocarcinoma cells. Jpn J Cancer Res, 87: 1227-1234, 1996.

33. Hagiwara, A., Matsuda, T., Tamano, S., Kitano, M., Imaoka, S., Funae, Y., Takesada, Y., Shirai, T., Fukushima, S.: Dose-related increases in quantitative values for altered hepatocytic foci and cytochrome P-450 levels in the livers of rats exposed to phenobarbital in a medium-term bioassay. Cancer Lett, 110: 155-162, 1996.

34. Ito, N., Hagiwara, A., Tamano, S., Futakuchi, M., Imaida, K., Shirai, T.: Effects of pesticide mixtures at the acceptable daily intake levels on rat carcinogenesis. Fd Chem Toxicol, 34: 1091-1096, 1996.

35. Cabral, R., Hoshiya, T., Hakoi, K., Hasegawa, R., Ito, N.: Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene., Cancer Lett, 100: 223-226, 1996.

36. Hasegawa, R., Kato, T., Hirose, M., Takahashi, S., Shirai, T., Ito, N.: Enhancement of hepatocarcinogenesis by combined administration of food-derived heterocyclic amines at low doses in the rat. Fd Chem Toxicol, 34: 1097-1101, 1996.

37. Sano, M., Tamano, S., Hagiwara, A., Kawabe, M., Nakamura, M., Imaida, K., Hirose, M.: 13-week oral toxicity study of pigments extracted from the purple sweet potato in F344/DuCrj rats. Jpn J Fd Chem, 3: 99-105, 1996.

38. Hagiwara, A., Kokubo, Y., Takesada, Y., Tanaka, H., Tamano, S., Hirose, M., Shirai, T., Ito, N.: Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats. Teratog Carcinog Mutagen, 16: 317-325, 1996.

39. Sano, M., Tamano, S., Hagiwara, A., Shirai, T., Hasegawa, R., Imaida, K., Ito, N.: Dose-response study of di(2-ethylhexyl)phthalate associated rat hepatocarcinogenesis. In: Tahara, E., Sugimachi, K., Oohara, T. (eds.), Recent Advances in Gastroenterological Carcinogenesis I. pp501-511. Monduzzi Editore S.p.A., Bologna, 1996.

40. Hagiwara, A., Tamano, S., Hirose, M.: Changes in the heart. In: U. Mohr, U. et al. (eds.), Pathobiology of the Aging Mouse. pp361-371, International Life Sciences Institute Press, Washington, DC., 1996.

41. Ito, N., Hirose, M., Futakuchi, M., Tamano, S., Shirai, T.: Chemoprevention of heterocyclic amine-induced carcinogenesis by exogenous agents: Stage dependent paradoxical effects. In: Conney, AH. Et al. (eds.), Fundamentals of Cancer Prevention. pp48-51. Princess Takamatsu Cancer Research Fund, Tokyo, 1996.

1. Kato, T., Ogiso, T., Kato, K., Sano, M., Hasegawa, R., Shirai, T., Ito, N.: Lack of promoting activity of four pesticides on induction of preneoplastic liver cell foci in rats. Teratog Carcinog Mutagen, 15: 251-257, 1995.

2. Hasegawa, R., Ogiso, T., Imaida, K., Shirai, T., Ito, N.: Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. Fd Chem Toxicol, 33: 15-20, 1995.

3. Shibata, MA., Sano, M., Hagiwara, A., Hasegawa, R., Shirai, T.: Modification by analgesics of lesion development in the urinary tract and various other organs of rats pretreated with dihydroxy-di-N- propylnitrosamine and uracil. Jpn J Cancer Res, 86: 160-167, 1995.

4. Tanaka, H., Hirose, M., Hagiwara, A., Imaida, K., Shirai, T., Ito, N.: Rat strain differences in catechol carcinogenicity to the stomach. Fd Chem Toxicol, 33: 93-98, 1995.

5. Ito, N., Hasegawa, R., Imaida, K., Kurata, Y., Hagiwara, A., Shirai, T.: Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis. Fd Chem Toxicol, 33: 159-163, 1995.

6. Ito, N., Hagiwara, A., Tamano, S., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T.: Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats. Toxicol Lett, 82-82: 513-520, 1995.

7. Hirose, M., Akagi, K., Hasegawa, R., Yaono, M., Satoh, T., Hara, Y., Wakabayashi, K., Ito, N.: Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats. Carcinogenesis, 16: 217-221, 1995.

8. Shirai, T., Shibata, MA., Takahashi, S., Tagawa, Y., Imaida, K., Hirose, M.: Differences in cell proliferation and apoptosis between reversible and irreversible mucosal lesions associated with uracil-induced urolithiasis in N-butyl-N-(4-hydroxybutyl)nitrosamine-pretreated rats. Carcinogenesis, 16: 501-505, 1995.

9. Tsukamoto, S., Akaza, H., Imada, S., Koiso, K., Shirai, T., Ideyama, Y., Kudo, M.: Chemoprevention of rat prostate carcinogenesis by use of finasteride or casodex. J Natl Cancer Inst, 87: 842-843, 1995.

10. Shibata, MA., Tanaka, H., Kawabe, M., Sano, M., Hagiwara, A., Shirai, T.: Lack of carcinogenicity of monosodium L-glutamate in Fischer 344 rats. Fd Chem Toxicol, 33: 383-391, 1995.

11. Iwata, H., Otoshi, T., Takada, N., Murai, T., Tamano, S., Watanabe, T., Katsura, Y., Fukushima, S.: Validation of silver-stained nucleolar organizer regions for evaluation of invasive character of urinary bladder carcinoma in rats and mice. Urol Res, 23: 27-32, 1995.

12. Tamano, S., Jakubczak, J., Takagi, H., Merlino, G., Ward, JM.: Increased susceptibility to N-nitrosomethylurea gastric carcinogenesis in transforming growth factor alpha transgenic mice with gastric hyperplasia. Jpn J Cancer Res, 86: 435-443, 1995.

13. Masui, T., Shirai, T., Imaida, K., Hirose, M., Futakuchi, M., Tatematsu, M., Ito, N.: Ki-ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2′-dimethyl-4-aminobiphenyl. Mol Carcinog, 13: 21-26, 1995.

14. Liang, YY., Esteve, A., Martel-Planche, G., Takahashi, S., Lu, SH., Montesano, R., Hollstein, M.: p53 mutations in esophageal tumors from high-incidence areas of China. Int J Cancer, 61: 611-614, 1995.

15. Shirai, T., Tamano, S., Sano, M., Imaida, K., Hagiwara, A., Futakuchi, M., Takahashi, S., Hirose, M.: Site-specific effects of testosterone propionate on the prostate of rat pretreated with 3,2′-dimethyl-4-aminobiphenyl: Dose-dependent induction of invasive carcinomas. Jpn J Cancer Res, 86: 645-648, 1995.

16. Tiwawech, D., Shibata, MA., Hasegawa, R., Hagiwara, A., Shirai, T., Thamavit, W., Fukushima, S.: Weak synergistic effect of uracil and N-butyl-N-(4-hydroxybutyl)nitrosamine on urine composition, epithelial morphology, and DNA synthesis in the urinary bladder of Syrian golden hamster. J Toxicol Pathol, 8: 129-137, 1995.

17. Kataoka, H., Katsumi, K., Kutsuna, T., Suzumura, H., Kojima, S., Takeshima, A., Ban, Y., Itoh, T., Kishimoto, A., Kato, M., Iwata, F., Itoh, M., Takeuchi, T., Ogawa, K., Shirai, T.: A case of familial adenomatous polyposis associated with colon cancer, ureteral cancer and two early gastric cancers. Dig Endosc, 7: 278-284, 1995.

18. Akagi, K., Hirose, M., Hoshiya, T., Mizoguchi, Y., Ito, N., Shirai, T.: Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model. Cancer Lett. 94: 113-121, 1995.

19. Yaono, M., Hasegawa, R., Mizoguchi, Y., Futakuchi, M., Nakamura, T., Ito, N., Shirai, T.: Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res, 86: 718-723, 1995.

20. Shirai, T., Fradet, Y., Huland, H., Bollack, C., Droller, M., Janknegt, R., Jones, P., Kagawa, S.: The etiology of bladder cancer — Are there any new clues or predictors of behavior? Int J Urol, 2 Suppl 2: 64-75, 1995.

21. Hirose, M., Iwata, S., Ito, E., Nihro, Y., Takahashi, S., Mizoguchi, Y., Miki, T., Satoh, T., Ito, N., Shirai, T.: Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido [1,2-a:3′,2′-d] imidazole (Glu-P-1). Carcinogenesis, 16: 2227-2232, 1995.

22. Hasegawa, R., Hirose, M., Kato, T., Hagiwara, A., Boonyaphiphat, P., Nagao, M., Ito, N., Shirai, T.: Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats. Carcinogenesis, 16: 2243-2246, 1995.

23. Ogawa, K., Shichino, Y., Tatematsu, M., Furihata, C., Asamoto, M., Nagase, S., Shirai, T., Ito, N.: Increasing development of pepsinogen-altered pyloric glands and adenocarcinoma in glandular stomach of analbuminemic rats. Cancer Lett, 96: 219-224, 1995.

24. Hasegawa, R., Kimura, J., Yaono, M., Takahashi, S., Kato, T., Futakuchi, M., Fukutake, M., Fukutome, K., Wakabayashi, K., Sugimura, T., Ito, N., Shirai, T.: Increased risk of mammary carcinoma development following transplacental and trans-breast milk exposure to a food-derived carcinogen, 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley rats. Cancer Res, 55: 4333-4338, 1995.

25. Hirose, M., Takahashi, S., Shirai, T.: Characteristics of forestomach carcinogenesis by non-genotoxic phenolic compounds. J Toxicol Pathol, 8: 277-284, 1995.

26. Shirai, T., Takahashi, S., Mori, T., Imaida, K., Futakuchi, M., Ye, SH., Prins, GS., Ito, N.: Immunohistochemically demonstrated androgen receptor expression in the rat prostate during carcinogenesis induced by 3,2’-dimethyl-4-aminobiphenyl with or without testosterone. Urol Oncol, 1: 263-268, 1995.

27. Shibata, M., Hasegawa, R., Imaida, K., Hagiwara, A., Ogawa, K., Hirose, M., Ito, N., Shirai, T.: Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model. Cancer Res, 55: 4870-4874, 1995.

28. Ogasawara, H., Imaida, K., Ishiwata, H., Toyoda, K., Kawanishi, T., Uneyama, C., Hayashi, S., Takahashi, M., Hayashi, Y.: Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation. Carcinogenesis, 16: 2773-2777, 1995.

29. Hirose, M., Hasegawa, R., Kimura, J., Akagi, K., Yoshida, Y., Tanaka, H., Miki, T., Satoh, T., Wakabayashi, K., Ito, N., Shirai, T.: Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline(MeIQx). Carcinogenesis, 16: 3049-3055, 1995.

30. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Asamoto, M., Shirai, T.: Concepts in multistage carcinogenesis. Crit Rev Oncol Hematol, 21: 105-133, 1995.

31. Shirai, T., Tamano, S., Sano, M., Masui, T., Hasegawa, R., Ito, N.: Carcinogenicity of 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies. In: Adamson, RH. et al. (eds.), Heterocyclic amines in cooked foods: Possible human carcinogens. pp232-239, Princeton Scientific Publishing Co. Inc., New Jersey, 1995.

32. Ito, N., Hasegawa, R., Asakawa, E., Hirose, M., Imaida, K., Hagiwara, A.: Enhancement of rat liver cell foci development by combined treatment with heterocyclic amines at low doses. In: In: Adamson, RH. et al. (eds.), Heterocyclic amines in cooked foods: Possible human carcinogens. pp251-258. Princeton Scientific Publishing Co. Inc., New Jersey, 1995.