1. Asakawa, E., Hirose, M., Hagiwara, A., Takahashi, S., Ito, N.: Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats. Int J Cancer, 56: 146-152, 1994.

2. Yoshida, Y., Hirose, M., Takaba, K., Kimura, J., Ito, N.: Induction and promotion of forestomach tumors by sodium nitrite in combination with ascorbic acid or sodium ascorbate in rats with or without N-methy1-N’-nitro-N-nitrosoguanidine pre-treatment. Int J Cancer, 56: 124-128, 1994.

3. Kawabe, M., Takaba, K., Yoshida, Y., Hirose, M.: Effects of combined treatment with phenolic compounds and sodium nitrite on two-stage carcinogenesis and cell proliferation in the rat stomach. Jpn J Cancer Res, 85: 17-25, 1994.

4. Hasegawa, R., Miyata, E., Futakuchi, M., Hagiwara, A., Nagao, M., Sugimura, T., Ito, N.: Synergistic enhancement of hepatic foci development by combined treatment of rats with 10 heterocyclic amines at low doses. Carcinogenesis, 15: 1037-1041,1994.

5. Shioya, S., Nagami-Oguihara, R., Oguihara, S., Kimura, T., Imaida, K., Fukushima, S.: Roles of bladder distention, urinary pH and urinary sodium ion concentration in cell proliferation of urinary bladder epithelium in rats ingesting sodium salts. Fd Chem Toxicol, 32: 165-171, 1994.

6. Thamavit, W., Pairojkul, C., Tiwawech, D., Shirai, T., Ito, N.: Strong promoting effect of Opistohorchis viverrini infection on dimethylnitrosamine-initiated hamster liver. Cancer Lett, 78: 121-125, 1994.

7. Puapairoj, P., Cui, L., Ogawa, K., Akagi, K., Hasegawa, R., Ito, N.: Effect of ethanol on papaquat toxicity in F344 rats. Fd Chem Toxicol, 32: 379-386, 1994.

8. de Camargo, JLV., de Oliveira, MLCS., Rocha, NS., Ito, N.: A deteccao de substancias cancerigenas em estudos experimentais. Rev Bras Cancerol, 40: 21-30, 1994.

9. Hirose, M., Satoh, T., Ito, N.: A strong new antioxidant with potent chemopreventive activity against heterocyclic amine-induced mutagenesis and carcinogenesis. HTHQ. Drug News Perspect, 7: 167-170, 1994.

10. Takaba, K., Hirose, M., Ogawa, K., Hakoi, K., Fukushima, S.: Modification of N-butyl-N -(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in rats by phytic acid and its salts. Fd Chem Toxicol, 32: 499-503, 1994.

11. Ito, N., Hasegawa, R., Imaida, K., Takahashi, S., Shirai, T.: Medium-term rat liver bioassay for rapid detection of carcinogens and modifiers of hepatocarcinogenesis. Drug Metab Rev, 26: 431-442, 1994.

12. Tanaka, H., Hagiwara, A., Kurata, Y., Ogiso, T., Futakuchi, M., Ito, N.: Thirteen-week oral toxicity study of magnesium chloride in B6C3F1 mice. Toxicol Lett, 73: 25-32, 1994.

13. Cui, L., Hasegawa, R., Zajdela, F., Puapairoj, P., Shirai, T., Ito, N.: Lack of promoting activity of 7-methoxy-2-nitro-naphtho-[2,1-b] furan (R7000) in a medium-term rat liver bioassay. Cancer Lett, 76: 161-166, 1994.

14. Nagao, M., Ushijima, T., Wakabayashi, K., Ochiai, M., Kushida, H., Sugimura, T., Hasegawa, R., Shirai, T., Ito, N.: Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods. Cancer, 74: 1063-1069, 1994.

15. Shibata, MA., Shirai, T., Takahashi, S., Takesada, Y., Iwata, H., Okumura, M., Fukushima, S.: Progressive growth of rat bladder carcinomas after exposure to prolonged uracil-induced urolithiasis. Teratog Carcinog Mutagen, 14: 157-168, 1994.

16. Thamavit, W., Pairojkul, C., Tiwawech, D., Shirai, T., Ito, N.: Lack of promoting effect of proline on bile duct cancer development in dimethylnitrosamine-initiated hamster livers. Teratog Carcinog Mutagen, 14: 169-174, 1994.

17. Hirose, M., Hoshiya, T., Akagi, K., Futakuchi, M., Ito, N.: Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[a]anthracene. Cancer Lett, 83: 149-156, 1994.

18. Hasegawa, R., Yoshida, T., Mizoguchi, Y., Futakuchi, M., Kim, DJ., Cui, L., Ito, N.: Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital. Cancer Lett, 83: 89-95, 1994.

19. Shirai, T., Sano, M., Imaida, K., Takahashi, S., Mori, T., Ito, N.: Duration dependent induction of invasive prostatic carcinomas with pharmacological dose of testosterone propionate in rats pretreated with 3,2′-dimethyl-4-aminobiphenyl and development of androgen-independent carcinomas after castration. Cancer Lett, 83: 111-116, 1994.

20. Yuasa, H., Hirano, K., Kodama, H., Nakanishi, H., Imai, T., Tsuda, H., Imaida, K., Tatematsu, M.: Immunohistochemical demonstration of intestinal-type alkaline phosphatase in stomach tumors induced by N-methyl-N’-nitro-N-nitrosoguanidine in rats. Jpn J Cancer Res, 85: 897-903, 1994.

21. Asamoto, M., Takahashi, S., Imaida, K., Shirai, T., Fukushima, S.: Increased gap junctional intercellular communication capacity and connexin 43 and 26 expression in rat bladder carcinogenesis. Carcinogenesis, 15: 2163-2166, 1994.

22. Shirai, T., Tada, M., Kojima, M., Hasegawa, R., Masui, T., Ito, N.: DNA adducts in target and nontarget tissues of 3,2′-dimethyl-4-aminobiphenyl in rats. Environ Health Perspect, 102: 167-172, 1994.

23. Hasegawa, R., Tanaka, H., Tamano, S., Shirai, T., Nagao, M., Sugimura, T., Ito, N.: Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay. Carcinogenesis, 15: 2567-2573, 1994.

24. Tamano, S., Hasegawa, R., Hagiwara, A., Nagao, M., Sugimura, T., Ito, N.: Carcinogenicity of a mutagenic compound from food, 2-amino-3-methyl-9H-pyrido[2,3-b] indole (MeAαC), in male F344 rats. Carcinogenesis, 15: 2009-2015, 1994.

25. Hagiwara, A., Tanaka, H., Tamano, S., Imaida, K., Takahashi, S., Fukushima, S.: Inhibiting effects of diethylmaleate or NH4Cl on NaHCO3, but not butylated hydroxyanisole, promotion of urinary bladder carcinogenesis in male F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. J Toxicol Sci, 19: 189-195, 1994.

26. Itoh, M., Pairojkul, C., Thamawit, W., Sithithaworn, P., Tiwawech, D., Uttaravicien, T., Shirai, T., Ito, N.: Association of antibodies to Opisthorchis viverrini with hepatobiliary disease in northeastern Thailand. Am J Trop Med Hyg, 51: 424-429,1994.

27. Masui, T., Don, I., Takada, N., Ogawa, K., Shirai, T., Fukushima, S.: p53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 15: 2379-2381, 1994.

28. Ushijima, T., Kakiuchi, H., Makino, H., Hasegawa, R., Ishizaka, Y., Hirai, H., Yazaki, Y., Ito, N., Sugimura, T., Nagao, M.: Infrequent mutation of Ha-ras and p53 in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Mol Carcinog, 10: 38-44, 1994.

29. Shibata, MA., Shirai, T., Ogawa, K., Takahashi, S., Wild, CP., Montesano, R., Tsuda, H., Ito, N.: DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)- nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea. Carcinogenesis, 15: 2965-2968, 1994.

30. Shirai, T., Imaida, K., Masui, T., Iwasaki, S., Mori, T., Kato, T., Ito, N.: Effects of testosterone, dihydrotestosterone and estrogen on 3,2-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis. Int J Cancer, 57: 224-228, 1994.

31. Takahashi, S., Asamoto, M., Nakazawa, T., Kosaki, T., Katsumi, K., Shirai, T.: Robb-Smith type malignant histiocytosis associated with a mediastinal germ cell tumor. Jpn J Clin Oncol, 24: 327-330, 1994.

32. Takahashi, S., Hasegawa, R., Mutai, M., Ito, N., Ochiai, M., Nagao, M., Sugimura, T.: Additive action of five heterocyclic amines in terms of induction of GST-P positive　single cells and foci in rat liver. Correlation with DNA adduct formation. J Toxicol Pathol, 7: 423-428, 1994.

33. Takashi, M., Sakata, T., Nakano, Y., Takagi, Y., Yamada, Y., Hibi, H., Miyake, K., Shirai, T.: Initiation-stage enhancement by uracil of N-ethyl-N-hydroxyethylnitrosamine-induction of kidney carcinogenesis in rats. Cancer Lett, 87: 151-157, 1994.

34. Tamano, S., Merlino, GT., Ward, JM.: Rapid development of hepatic tumors in transforming growth factor α transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital. Carcinogenesis, 15: 1791-1798, 1994.

35. Hasegawa, R., Ito, N.: Hepatocarcinogenesis in the rat. In: Waalkes, MP. & Ward, JM. (eds.) Carcinogenesis, pp39-65. Raven Press Ltd., New York, 1994.

36. Hirose, M., Imaida, K., Tamano, S., Ito, N.: Cancer chemoprevention by antioxidants. In: Ho, CH. et al (eds.) Food Phytochemicals for Cancer Prevention II -Teas, Spices, and Herbs-, pp122-132. American Chemical Society, Washington, D.C., 1994.

37. Hasegawa, R., Takayama, S., Ito, N.: Effects of low level exposure to multiple carcinogens in combination. Toxicology of Chemical Mixtures, 15: pp361-382, Academic Press, 1994.

38. Ito, N., Imaida, K.: Identification of chemopreventive agents and their evaluation. In: Rao, RS et al. (eds.) XVI Proceedings of the International Cancer Congress, pp159-164, Monduzzi Editore S.p.A., Bologna, 1994.

1. Shirai, T., Imaida, K., Iwasaki, S., Mori, T., Tada, M., Ito, N.: Sequential observation of rat prostate lesion development induced by 3,2′-dimethyl-4-aminobiphenyl and testosterone. Jpn J Cancer Res, 84: 20-25, 1993.

2. Hirose, M., Tanaka, H., Takahashi, S., Futakuchi, M., Fukushima, S., Ito, N.: Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model. Cancer Res, 53: 32-37, 1993.

3. Thamavit, W., Moore, MA., Sirisinha, S., Shirai, T., Ito, N.: Time-dependent modulation of liver lesion development in Opisthorchis-infected Syrian hamster by an antihelminthic drug, praziquantel. Jpn J Cancer Res, 84: 135-138, 1993.

4. Shibata, MA., Hirose, M., Kagawa, M., Boonyaphiphat, P., Ito, N.: Enhancing effect of concomitant L-ascorbic acid administration on BHA-induced forestomach carcinogenesis in rats. Carcinogenesis, 14: 275-280, 1993.

5. Mizoguchi, M., Naito, H., Kurata, Y., Shibata, MA., Tsuda, H., Wild, CP., Montesano, R., Fukushima, S.: Influence of aging on multi-organ carcinogenesis in rats induced by N-methyl-N-nitrosourea. Jpn J Cancer Res, 84: 139-146, 1993.

6. Tamano, S., Kawabe, F., Sano, M., Masui, T., Ito, N.: Subchronic oral toxicity study of captafol in B6C3F1 mice. J Toxicol Environ Health, 38: 69-75, 1993.

7. Hagiwara, A., Tanaka, H., Imaida, K., Tamano, S., Fukushima, S., Ito, N.: Correlation between medium-term multi-organ carcinogenesis bioassay data and long-term observation results in rats. Jpn J Cancer Res, 84: 237-245, 1993.

8. Hirose, M., Fukushima, S., Tanaka, H., Asakawa, E., Takahashi, S., Ito, N.: Carcinogenicity of catechol in F344 rats and B6C3F1 mice. Carcinogenesis, 14: 525-529, 1993.

9. Shibata, MA., Shirai, T., Asakawa, E., Hirose, M., Fukushima, S.: Inhibition by dehydroepiandrosterone of butylated hydroxyanisole (BHA) promotion of rat-bladder carcinogenesis and enhancement of BHA-induced forestomach hyperplasia. Int J Cancer, 53: 819-823, 1993.

10. Hirose, M., Akagi, K., Hasegawa, R., Satoh, T., Nihro, Y., Miki, T., Sugimura, T., Ito, N.: Strong inhibition of 2-amino-6-methyldipyrido[1,2-a: 3′, 2′-d]imidazole-induced mutagenesis and hepatocarcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone. Jpn J Cancer Res, 84: 481-484, 1993.

11. Tamano, S., Tanaka, H., Kawabe, M., Asakawa, E., Sano, M., Shioya, S., Shirai, T., Fukushima, S.: No enhancing effects of calcium / magnesium salts of L-glutamate and L-ascorbate on tumor development in a rat medium-term multiorgan carcinogenesis bioassay. J Toxicol Environ Health, 39: 43-58, 1993.

12. Toyoda, K., Imaida, K., Shirai, T., Imazawa, T., Takahashi, M.: Relationship between bisacodyl-induced urolithiasis and rat urinary bladder tumorigenesis. J Toxicol Environ Health, 39: 59-78, 1993.

13. Hasegawa, R., Cabral, R., Hoshiya, T., Hakoi, K., Ogiso, T., Boonyaphiphat, P., Shirai, T., Ito, N.: Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats. Int J Cancer, 54: 489-493, 1993.

14. Suzuki, S., Tamura, Y., Takazawa, Y., Mashimo, T., Imai, K., Yuasa, H., Yamanaka, H., Shirai, T.: Ultrasonic diagnosis of 3,2′-dimethyl-4-aminobiphenyl induced tumors in the urogenital organs of F344 rats. Prostate, 22: 235-241, 1993.

15. Tatematsu, M., Ichinose, M., Tsukada, S., Kakei, N., Takahashi, S., Ogawa, K., Hirose, M., Furihata, C., Miki, K., Kurokawa, K., Ito, N.: DNA methylation of the pepsinogen 1 gene during rat glandular stomach carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine or catechol. Carcinogenesis, 14: 1415-1419, 1993.

16. Shibata, MA., Hirose, M., Masuda, A., Kato, T., Mutai, M., Ito, N.: Modification of BHA forestomach carcinogenesis in rats: inhibition by diethylmaleate or indomethacin and enhancement by a retinoid. Carcinogenesis, 14: 1265-1269, 1993.

17. Tamano, S., Asakawa, E., Boonyaphiphat, P., Masui, T., Fukushima, S.: Lack of promotion of N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in mice by rat cancer promoters. Teratog Carcinog Mutagen, 13: 89-96, 1993.

18. Kurata, Y., Diwan, BA., Uno, H., Rice, JM., Ward. JM.: Pathology of preneoplastic and neoplastic renal tubular lesions induced in F-344 rats by sodium barbital, a nongenotoxic renal carcinogen and nephrotoxin. Toxicol Pathol, 21: 35-45, 1993.

19. Shrai, T.: Etiology of bladder cancer. Semin Urol, 11: 113-126, 1993.

20. Shibata, MA., Sano, M., Shirai, T., Imaida, K., Fukushima, S.: Epithelial hyperplasia in the renal papilla and pelvis but not the urinary bladder of male F344 rats associated with dietary sodium phosphates after uracil exposure. Toxicol Appl Pharmacol, 121: 303-312, 1993.

21. Okazaki, S., Hoshiya, T., Takahashi, S., Futakuchi, M., Saito, K., Hirose, M.: Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-ethyl-N-hydroxyethylnitrosamine. Teratog Carcinog Mutagen, 13: 127-137, 1993

22. Hirose, M., Hoshiya, T., Akagi, K., Takahashi, S., Hara, Y., Ito, N.: Effects of green tea catechins in a rat multi-organ carcinogenesis model. Carcinogenesis, 14: 1549-1553, 1993.

23. Tatematsu, M., Iwata, H., Ichinose, M., Kakei, N., Tsukada, S., Miki, K., Imai, S., Imaida, K.: Markers of surface mucous cell type human gastric cancer cells: Galactose oxidase-Schiff reactive mucins, monoclonal antibody SH-9 reactive mucins and cathepsin E. Acta Pathol Jpn, 43: 500-506, 1993.

24. Kawabe, M., Tamano, S., Shibata, MA., Hirose, M., Fukushima, S., Ito, N.: Subchornic toxicity study of methyl hesperidin in mice. Toxicol Lett, 69: 37-44, 1993.

25. Hoshiya, T., Hasegawa, R., Hakoi, K., Cui, L., Ogiso, T., Cabral, R., Ito, N.: Enhancement by non-mutagenic pesticides of GST-P positive hepatic foci development initiated with diethylnitrosamine in the rat. Cancer Lett, 72: 59-64, 1993.

26. Hagiwara, A., Ogiso, T., Shibata, MA., Shirai, T.: Spontaneous pleomorphic adenoma in the submandibular salivary gland of an aged male (C57BL/6N×C3H/HeN) F1 (B6C3F1) mouse. Vet Pathol, 30: 394-396, 1993.

27. Tiwawech, D., Siripong, P., Kupradinun, P., Thamavit, W., Shirai, T., Hagiwara, A., Ito, N.: Inhibition of diethylnitrosamine (DEN)-induced hepatic foci by pre and post treatment with Acanthus ebracteatus Vahl. in rats. Thai Cancer J, 19: 7-13, 1993.

28. Shirai, T., Iwasaki, S., Masui, T., Mori, T., Kato, T., Ito, N.: Enhancing effect of cadmium on rat ventral prostate carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl. Jpn J Cancer Res, 84: 1023-1030, 1993.

29. Kagawa, M., Hakoi, K., Yamamoto, A., Futakuchi, M., Hirose, M.: Comparison of reversibility of rat forestomach lesions induced by genotoxic and non-genotoxic carcinogens. Jpn J Cancer Res, 84: 1120-1129, 1993.

30. Takahashi, S., Shirai, T., Ogawa, K., Imaida, K., Yamazaki, C., Ito, A., Masuko, K., Ito, N.: Renal cell adenomas and carcinomas in hemodialysis patients: Relationship between hemodialysis period and development of lesions. Acta Pathol Jpn, 43: 674-682, 1993.

31. Hirose, M., Yada, H., Hakoi, K., Takahashi, S., Ito, N.: Modification of carcinogenesis by α-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model. Carcinogenesis, 14: 2359-2364, 1993.

32. Thamavit, W., Pairojkul, C., Tiwawech, D., Itoh, M., Shirai, T., Ito, N.: Promotion of cholangiocarcinogenesis in the hamster liver by bile duct ligation after dimethylnitrosamine initiation. Carcinogenesis, 14: 2415-2417, 1993.

33. Yamaguchi, S., Hakoi, K., Ozaki, K., Kato, T., Tiwawech, D., Nagao, S., Takahashi, H., Matsumoto, K., Tsuda, H.: Number of simultaneously expressed enzyme alterations correlates with progression of N-ethyl-N-hydroxyethylnitrosamine-induced hepatocarcinogenesis in rat. Jpn J Cancer Res, 84: 1237-1244, 1993.

34. Ozaki, K., Kato, T., Asamoto, M., Wild, CP., Montesano, R., Nagao, S., Iwase, T., Matsumoto, K., Tsuda, H.: Decreased dimethylnitrosamine-induced O6-and N7-methy1deoxyguanosine levels correlate with development and progression of lesions in rat hepatocarcinogenesis. Jpn J Cancer Res, 84: 1245-1251, 1993.

35. Kato, T., Imaida, K., Ogawa, K., Hasegawa, R., Shirai, T., Tatematsu, M.: Three-dimensional analysis of glutathione S-transferase placental form-positive lesion development in early stages of rat hepatocarcinogenesis. Jpn J Cancer Res, 84: 1252-1257, 1993.

36. de Camargo, JLV., Tsuda, H., Asamoto, M., Tagawa, Y., Wada, S., Nagase, S., Ito, N.: Modifying effects of chemicals on the development of liver preneoplastic placental glutathione S-transferase positive foci in analbuminemic and Sprague-Dawley rats. Toxicol Pathol, 21: 409-416, 1993.

37. Shibata, MA., Hasegawa, R., Shirai, T., Takesada, Y., Fukushima, S.: Chemoprevention by indomethacin of tumor promotion in a rat urinary bladder carcinogenesis model. Int J Cancer, 55: 1011-1017, 1993.

38. Hagiwara, A., Tiwawech, D., Imaida, K., Tamano, S., Shibata, MA., Fukushima, S., Ito, N.: Modifying influence of prior treatment with toxic agents on induction of preneoplastic and neoplastic lesions in a medium-term multi-organ carcinogenesis bioassay. Teratog Carcinog Mutagen, 13: 277-287, 1993.

39. Yoshida, Y., Tatematsu, M., Takaba, K., Iwasaki, S., Ito, N.: Target organ specificity of cell proliferation induced by various carcinogenesis. Toxicol Pathol, 21: 436-442, 1993.

40. Hasegawa, R., Sano, M., Tamano, S., Imaida, K., Shirai, T., Nagao, M., Sugimura, T., Ito, N.: Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats. Carcinogenesis, 14: 2553-2557, 1993.

41. Shibata, MA., Kurata, Y., Hagiwara, A., Shirai, T., Fukushima, S: Lack of tumorigenic effects on rat renal pelvic transitional epithelium of lifespan exposure to low doses of a bladder carcinogen. J Toxicol Pathol, 6: 47-53, 1993.

42. Ito, N., Hirose, M., Takahashi, S.: Cell proliferation and forestomach carcinogenesis. Environ Health Perspect, 101: 107-110, 1993.

43. Ito, N., Hasegawa, R., Cabral, JRP.: Medium-term in vivo bioassays for carcinogenicity of pesticides. In: Roe, RM. & Kuhr, RJ. (eds.) Rev Pestic Toxicol, 2, pp115-132: Toxicology Communications Inc., Raleigh, NC, 1993.

44. Hirose, M., Shirai, T., Takahashi, S., Ogawa, K., Ito, N.: Organ-specific modification of carcinogenesis by antioxidants in rats. In: Bronzetti, G., et al.(eds.) Antimutagenesis and Anticarcinogenesis Mechanisms III, pp 181-188. Plenum Press, New York, 1993.

1. Thamavit, W., Boonpucknavig, V., Boonpucknavig, S., Moore, MA., Ito, N.: Secondary enhancing effect of Opisthirchis viverrini infection on development of hepatocellular nodules in Syrain golden hamsters initiated with diethylnitrosamine. Thai J Toxicol, 8: 35-40, 1992.

2. Shibata, MA., Fukushima, S., Asakawa, E., Hirose, M., Ito, N.: The modifying effects of indomethacin or ascorbic acid on cell proliferation induced by different types of bladder tumor promoters in rat urinary bladder and forestomach mucosal epithelium. Jpn J Cancer Res, 83: 31-39, 1992.

3. Kojima, M., Morita, T., Shirai, T., Degawa, M., Tada, M.: Immunological detection and quantitation of DNA adducts formed by 4-aminoazobenzene species in vivo. Jpn J Cancer Res, 83: 78-85, 1992.

4. Thamavit, W., Moore, MA., Ruchirawat, S., Ito, N.: Repeated exposure to Opisthorchis viverrini and treatment with the antihelminthic Praziquantel lacks carcinogenic potential. Carcinogenesis, 13: 309-311, 1992.

5. Ito, N.: Is quercetin carcinogenic? Jpn J Cancer Res, 83: 312-314, 1992.

6. Asamoto, M., Imaida, K., Hasegawa, R., Hotta, K., Fukushima, S.: Change of membrane potential in rat urinary bladder epithelium treated with sodium L-ascorbate. Cancer Lett, 63: 1-5, 1992.

7. Hirose, M., Wada, S., Yamaguchi, S., Masuda, A., Okazaki, S., Ito, N.: Reversibility of catechol-induced rat glandular stomach lesions. Cancer Res, 52: 787-790, 1992.

8. Ueno, Y., Yabe, T., Hashimoto, H., Sekijima, M., Masuda, T., Kim, DJ., Hasegawa, R., Ito, N.: Enhancement of GST-P-positive liver cell foci development by nivalenol, a trichothecene mycotoxin. Carcinogenesis, 13: 787-791, 1992.

9. Hasegawa, R., Tiwawech, D., Hirose, M., Takaba, K., Hoshiya, T., Shirai, T., Ito, N.: Suppression of diethylnitrosamine-initiated preneoplastic foci development in the rat liver by combined administration of four antioxidants at low doses. Jpn J Cancer Res, 83: 431-437, 1992.

10. Kushida, H., Wakabayashi, K., Suzuki, M., Takahashi, S., Imaida, K., Sugimura, T., Nagao, M.: Suppression of spontaneous hepatocellular carcinoma development in C3H/HeNCrj mice by the lipophilic ascorbic acid, 2-O-octadecylascorbic acid (CV-3611). Carcinogenesis, 13: 913-915, 1992.

11. Okumura, M., Hasegawa, R., Shirai, T., Ito, M., Yamada, S., Fukushima, S.: Relationship between calculus formation and carcinogenesis in the urinary bladder of rats administered the non-genotoxic agents, thymine or melamine. Carcinogenesis, 13: 1043-1045, 1992.

12. Imaida, K., Uneyama, C., Ogasawara, H., Hayashi, S., Fukuhara, K., Miyata, N., Takahashi, M.: Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: Comparison of carcinogenicity and aryl hydrocarbon hydroxylase induction in the target organs of each species. Cancer Res, 52: 1542-1545, 1992.

13. Tagawa, Y., Ozaki, K., Takahashi, S., Ogawa, K., Shirai, T.: Lack of effects of post-initiation cholesterol on 3,2′-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis. Prostate, 20: 179-185, 1992.

14. Kagawa, M., Yamamoto, A., Ogawa, K., Shirai, T., Fukushima, S.: Uracil-induced urolithiasis in the urinary bladder of rats is irritation-dependent. Toxicol Lett, 61: 21-26, 1992.

15. Ogawa, K., Hasegawa, R., Wada, S., Yamaguchi, S., Ito, N.: Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis. Teratog Carcinog Mutagen, 11: 245-250, 1992.

16. Takahashi, S., Shirai, T., Hasegawa, R., Imaida, K., Ito, N.: Latent prostatic carcinomas found at autopsy in men over 90 years old. Jpn J Clin Oncol, 22: 117-121, 1992.

17. Shirai, T., Iwasaki, S., Naito, H., Masui, T., Kato, T., Imaida, K.: Dose dependence of N-hydroxy-3,2′-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis. Jpn J Cancer Res, 83: 695-698, 1992.

18. Ogawa, K., Hoshiya, T., Kato, T., Shirai, T., Tatematsu, M.: Reversibility of carcinogen-induced rat forestomach basal cell hyperplasia is due to squamous cell differentiation. Jpn J Cancer Res, 83: 699-704, 1992.

19. Fukushima, S., Tanaka, H., Asakawa, E., Kagawa, M., Yamamoto, A., Shirai, T.: Carcinogenicity of uracil, a nongenotoxic chemical, in rats and mice and its rationale. Cancer Res, 52: 1675-1680, 1992.

20. Uwagawa, S., Tsuda, H., Ozaki, K., Takahashi, S., Yamaguchi, S., Mutai, M., Aoki, T., Ito, N.: Modifying effects of various chemicals on tumor development in a rat wide-spectrum organ carcinogenesis model. Jpn J Cancer Res, 83: 812-820, 1992.

21. Shibata, MA., Tamano, S., Shirai, T., Kawabe, M., Fukushima, S.: Inorganic alkalizers and acidifiers under conditions of high urinary Na+ or K+ on cell proliferation and two-stage carcinogenesis in the rat bladder. Jpn J Cancer Res, 83: 821-829, 1992.

22. Hasegawa, R., Takahashi, S., Shirai, T., Iwasaki, S., Kim, DJ., Ochiai, M., Nagao, M., Sugimura, T., Ito, N.: Dose-dependent formation of preneoplastic foci and DNA adducts in rat liver with 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 13: 1427-1431, 1992.

23. Tatematsu, M., Ogawa, K., Hoshiya, T., Shichino, Y., Kato, T., Imaida, K., Ito, N.: Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea. Jpn J Cancer Res, 83: 915-918, 1992.

24. Hagiwara, A., Sano, M., Asakawa, E., Tanaka, H., Hasegawa, R., Ito, N.: Enhancing effects of harman and norharman on induction of preneoplastic and neoplastic kidney lesions in rats initiated with N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res, 83: 949-954, 1992.

25. Ono, S., Kurata, Y., Shichino, Y., Sano, M., Fukushima, S.: Synergism of environmental carcinogens and promoters on bladder cancer development initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine in F344 rats. Jpn J Cancer Res. 83: 955-963, 1992.

26. Takahashi, S., Hakoi, K., Yada, H., Hirose, M., Ito, N., Fukushima, S.: Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats. Carcinogenesis, 13: 1513-1518, 1992.

27. Hagiwara, A., Boonyaphiphat, P., Kawabe, M., Naito, H., Shirai, T., Ito, N.: Lack of carcinogenicity of tragacanth gum in B6C3F1 mice. Fd Chem Toxicol, 30: 673-679, 1992.

28. Hirose, M., Kawabe, M., Shibata, M., Takahashi, S., Okazaki, S., Ito, N.: Influence of caffeic acid and other o-dihydroxybenzene derivatives on N-methyl-N’-nitro-N-nitrosoguanidine-initiated rat forestomach carcinogenesis. Carcinogenesis, 13: 1825-1828, 1992.

29. Shirai, T., Pairojkul, C., Ogawa, K., Naito, H., Thamavit, W., Bhudhisawat, W., Ito, N.: Histomorphological characteristics of cholangiocellular carcinomas in Northeast Thailand, where a region infection with the liver fluke, Opisthochis viverrini is endemic. Acta Pathol Jpn, 42: 734-739, 1992.

30. Shichino, Y., Tatematsu, M., Ohshima, H., Bartsch, H., Furihata, C., Ito, N.: Effects of hickory-smoke condensate on development of pepsinogen 1-altered pyloric glands in rats. Fd Chem Toxicol, 30: 859-864, 1992.

31. Tsuda, H., Ozaki, K., Uwagawa, S., Yamaguchi, S., Hakoi, K., Aoki, T., Kato, T., Sato, K., Ito, N.: Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats. Jpn J Cancer Res, 83: 1154-1165, 1992.

32. Shirai, T., Yamamoto, A., Imaida, K., Tamano, S., Mori, T., Hasegawa, R.: Lack of synergism among DMAB, BOP, and MNU in induction of carcinomas of the rat ventral prostate. Teratog Carcinog Mutagen, 12: 71-77, 1992.

33. Ito, N., Imaida, K.: Strategy of research for cancer-chemoprevention. Teratog Carcinog Mutagen, 12: 79-95, 1992.

34. Hagiwara, A., Asakawa, E., Kurata, Y., Sano, M., Hirose, M., Ito, N.: Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats. Toxicol Pathol, 20: 197-204, 1992.

35. Tamano, S., Shirai, T., Kawabe, M., Ni-I, H., Mori, Y., Okada, M., Fukushima, S.: Low-susceptibility of nude mice to induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine. Toxicol Pathol, 20: 205-211, 1992.

36. Tamano, S., Hirose, M., Tanaka, H., Asakawa, E., Ogawa, K., Ito, N.: Forestomach neoplasm induction in F344/DuCrj rats and B6C3F1 mice exposed to sesamol. Jpn J Cancer Res, 83: 1279-1285, 1992.

37. Hasegawa, R., Ogawa, K., Takaba, K., Shirai, T., Ito, N.: 3,2′-dimethyl-4-aminobiphenyl-induced gallbladder carcinogenesis and effects of ethinyl estradiol in hamsters. Jpn J Cancer Res, 83: 1286-1292, 1992.

38. Hasegawa, R., Ito, N.: Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis. Fd Chem Toxicol, 30: 979-992, 1992.

39. Harris, CC., Hirohashi, S., Ito, N., Pitot, HC., Sugimura, T., Terada, M., Yokota, J.: Multistage carcinogenesis : The Twenty-Second International Symposium of the Princess Takamatsu Cancer Research Fund (Meeting report). Cancer Res, 52: 4837-4840, 1992.

40. Ito, N., Hasegawa, R., Imaida, K., Masui, T., Takahashi, S., Shirai, T.: Pathological markers for non-genotoxic agent-associated carcinogenesis. Toxicol Lett, 64/65: 613-620, 1992.

41. Takahashi, S., Hasegawa, R., Masui, T., Mizoguchi, M., Fukushima, S., Ito, N.: Establishment of multi-organ carcinogenesis bioassay using rats treated with a combination of five different carcinogens. J Toxicol Pathol, 5: 151-156, 1992.

42. Yoshida, Y., Tatematsu, M., Takaba, K., Shichino, Y., Ito, N.: Effects of various bile acids and their sodium salts on development of pepsinogen-altered pyloric glands in rats. Taratog Carcinog Mutagen, 12: 179-186, 1992.

43. Yoshida, Y., Hasegawa, R., Takaba, K., Imaida, K., Ito, N.: N-nitrosoheptamethyleneimine-induced pulmonary and esophageal carcinogenesis and effects of concomitant treatment with bleomycin in rats. Teratog Carcinog Mutagen, 12: 197-201, 1992.

44. Hakoi, K., Cabral, R., Hoshiya, T., Hasegawa, R., Shirai, T., Ito, N.: Analysis of carcinogenic activity of some pesticides in a medium-term liver bioassay in the rat. Teratog Carcinog Mutagen, 12: 269-276, 1992.

45. Hasegawa, R., Wang, CY., Kim, DJ., Lee, MS., Yoshida, Y., Ito, N.: Effect of acyl derivatives of 4,4,4-trifluoro-1-phenyl-1,3-butanedione on 2-acetylaminofluorene-induced glutathione S-transferase positive foci in the rat liver. Teratog Carcinog Mutagen, 12: 263-268, 1992.

46. Kurata, Y., Diwan, BA., Ward, JM.: Lack of renal tumour-initiating activity of a single does of potassium bromate, a genotoxic renal carcinogen in male F344/NCr rats. Fd Chem Toxicol, 30: 251-259, 1992.

47. Ito, N., Shirai, T., Hasegawa, R.: Medium-term bioassays for carcinogens. In: Vainio, H. et al. (eds.) Mechanisms of Carcinogenesis in Risk Identification, pp353-388. International Agency for Research on Cancer, Lyon, 1992.

48. Shirai, T., Tamano, S., Iwasaki, S., Ito, N.: Enhancement of prostate carcinogenesis in rats by testosterone and prolactin. In: Li, JJ. et al. (eds.) Hormonal Carcinogenesis, pp27-32. Springer-Verlag, 1992.

49. Mori, S., Murai, T., Ohhara, T., Hosono, M., Takeuchi, Y., Makino, S., Hayashi, Y., Fukushima, S.: Renal lesions and urinary bladder carcinogenesis. In: Sakamoto, N., Hotta, N. & Uchiba, K. (eds.) Current concepts of a new animal model: The NON mouse, pp159-174: Elsevier Science Publishers B.V., 1992.

50. Ito, N., Shirai, T., Masui, T., Ogawa, K., Kato, T., Takahashi, S.: Mechanistic analysis of multistage carcinogenesis in the rat prostate. In: Harris, CC. et al. (eds.) Multistage Carcinogenesis, pp125-133. Japan Sci Soc Press/CRC Press, Tokyo, 1992.

51. Shirai, T., Tamano, S., Takahashi, S., Ito, N.: Animal prostate carcinoma models: Limited potential for vertebral metastasis. In: Karr, JP. & Yamanaka, H. (eds.) Prostate Cancer and Bone Metastasis, pp151-158. Plenum Press, New York, 1992.

52. Pairojukul, C., Shirai, T., Hirohashi, S., Thamavit, W., Bhudhisawat, W., Uttaravicien, T., Itoh, M., Ito, N.: Multistage carcinogenesis of liver-fluke-associated cholangiocarcinoma in Thailand. In: Harris, CC. et al. (eds.) Multistage Carcinogenesis, pp77-86. Japan Sci. Soc. Press / CRC Press, Tokyo, 1992.

53. Ito, N., Hirose, M., Shirai, T.: Carcinogenicity and modification of carcinogenic response by plant phenols. In: Huang, MT., Ho, CT. & Lee, CY. (eds.) Phenolic Compounds in Food and Their Effects on Health II, 507, pp269-281. American Chemical Society, Washington D.C., 1992.

54. Cabral, R., Hoshiya, T., Hakoi, K., Hasegawa, R., Fukushima, S., Ito, N: A rapid in-vivo bioassay for the carcinogenicity of pesticides. In: Somogyi, A., Appel, KE. & Katenkamp A. (eds.) Chemical Carcinogenesis, pp91-96. MMV Medizin Verl., Munchen, 1992.

55. Ito, N., Hirose, M., Takahashi, S., Shirai, T.: Antioxidants — carcinogenesis and its modification. In: Somogyi, A., Appel, KE. & Katenkamp A. (eds.) Chemical Carcinogenesis, pp91-96. MMV Medizin Verl., Munchen, 1992.

56. Tsuda, H., Ito, N. : Medium-term bioassays as new tools for prediction of carcinogenicity. In: McAuslane, JAN., Lumley, CE. & Walker, SR. (eds.) The Carcinogenicity Debate, pp197-213. Quay Publishing, London, 1992.

1. Takahashi, S., Ogawa, K., Ohshima, H., Esumi, H., Ito, N., Sugimura, T.: Induction of aberrant crypt foci in the large intestine of F344 rats by oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res, 82: 135-137, 1991.

2. Tatematsu, M., Ogawa, K., Mutai, M., Aoki, T., Hoshiya, T., Ito, N.: Rapid regression of squamous cell hyperplasia and slow regression of basal cell hyperplasia in the forestomach of F344 rats treated with N-methyl-N’-nitro-N-nitrosoguanidine and/or butylated
hydroxyanisole. Cancer Res, 51: 318-323, 1991.

3. Okumura, M., Shirai, T., Tamano, S., Ito, M., Yamada, S., Fukushima, S.: Uracil-induced calculi and carcinogenesis in the urinary bladder of rats treated simultaneously with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 12: 35-41, 1991.

4. Shibata, MA., Asakawa, E., Hagiwara, A., Kurata, Y., Fukushima, S.: DNA synthesis and scanning electron microscopic lesions in renal pelvic epithelium of rats treated with bladder cancer promoters. Toxicol Lett, 55: 263-272, 1991.

5. Hasegawa, R., Takahashi, S., Imaida, K., Yamaguchi, S., Shirai, T., Ito, N.: Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine. Jpn J Cancer Res, 82: 293-297, 1991.

6. Hirose, M., Mutai, M., Takahashi, S., Yamada, M., Fukushima, S., Ito, N.: Effects of phenolic antioxidants in low dose combination on forestomach carcinogenesis in rats pretreated with N-methyl-N’-nitro-N-nitrosoguanidine. Cancer Res, 51: 824-827,1991.

7. Shirai, T., Tamano, S., Kato, T., Iwasaki, S., Takahashi, S., Ito, N.: Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2-dimethyl-4-aminobiphenyl and testosterone propionate. Cancer Res, 51:1264-1269, 1991.

8. Ochiai, M., Ogawa, K., Wakabayashi, K., Sugimura, T., Nagase, S., Esumi, H., Nagao, M.: Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats. Jpn J Cancer Res, 82:363-366, 1991.

9. Ito, N., Hasegawa, R., Shirai, T., Fukushima, S., Hakoi, K., Takaba, K., Iwasaki, S., Wakabayashi, K., Nagao, M., Sugimura, T.: Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses. Carcinogenesis, 12: 767-772, 1991.

10. Tiwawech, D., Hasegawa, R., Kurata, Y., Tatematsu, M., Shibata, MA., Thamavit, W., Ito, N.: Does-dependent effects of 2-acetylaminofluorene on hepatic foci development and cell proliferation in rats. Carcinogenesis, 12: 985-990, 1991.

11. Fukushima, S., Hagiwara, A., Hirose, M., Yamaguchi, S., Tiwawech, D., Ito, N.: Modifying effects of various chemicals on preneoplastic and neoplastic lesion development in a wide-spectrum organ carcinogenesis model using F344 rats. Jpn J Cancer Res, 82: 642-649, 1991.

12. Tamano, S., Hagiwara, A., Suzuki, E., Okada, M., Shirai, T., Fukushima, S.: Time- and dose-dependent induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine in B6C3F1 mice. Jpn J Cancer Res, 82: 650-656, 1991.

13. Hasegawa, R., Fukuoka, M., Takahashi, T., Yamamoto, A., Yamaguchi, S., Shibata, MA., Tanaka, A., Fukushima, S.: Sex differences in o-phenylphenol and sodium o-phenylphenate rat urinary bladder carcinogenesis: Urinary metabolites and electrolytes under conditions of aciduria and alkalinuria. Jpn J Cancer Res, 82: 657-664, 1991.

14. Okumura, M., Shirai, T., Asamoto, M., Ogiso, T., Fukushima, S.: Lack of synergism in rat urinary tract carcinogenesis between prior uracil treatment and N-butyl-N-(4-hydroxybutyl)nitrosamine administration. Cancer Lett, 58: 81-85, 1991.

15. Fukushima, S., Kurata, Y., Hasegawa, R., Asamoto, M., Shibata, MA., Tamano, S.: L-Ascorbic acid amplification of bladder carcinogenesis promotion by K2CO3. Cancer Res, 51: 2548-2551, 1991.

16. Fukushima, S., Shibata, MA., Hirose, M., Kato, T., Tatematsu, M., Ito, N.: Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model. Jpn J Cancer Res, 82: 784-792, 1991.

17. Shirai, T., Fukushima, S., Kawabe, M., Shibata, MA., Iwasaki, S., Tada, M., Ito, N.: Selective induction of rat urinary bladder tumors by simultaneous administration of 3,2′-dimethyl-4-aminobiphenyl (DMAB) and butylated hydroxyanisole or butylated hydroxytoluene is associated with increased DMAB-DNA adduct formation. Carcinogenesis, 12: 1335-1339, 1991.

18. Nakamura, A., Shirai, T., Takahashi, S., Ogawa, K., Hirose, M., Ito, N.: Lack of modification by naturally occurring antioxidants of 3,2′-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis. Cancer Lett, 58: 241-246, 1991.

19. Tamano, S., Kurata, Y., Shibata, MA., Tanaka, H., Ogiso, T., Ito, N.: 13-week oral toxicity study of captafol in F344/DuCrj rats. Fundam Appl Toxicol, 17: 390-398, 1991.

20. Ito, N., Hasegawa, R., Sano, M., Tamano, S., Esumi, H., Takayama, S., Sugimura, T.: A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 12: 1503-1506, 1991.

21. Hasegawa, R., Shirai, T., Hakoi, K., Wada, S., Yamaguchi, K., Takayama, S.: Synergistic enhancement of thyroid tumor induction by 2,4-diaminoanisole sulfate, N,N’-diethylthiourea and 4,4′-thiodianiline in male F344 rats. Carcinogenesis, 12:1515-1518, 1991.

22. Shibata, MA., Hasegawa, R., Sano, M., Shirai, T., Fukushima, S.: Timing effects of uracil-induced urolithiasis on amplification of second-stage promotion in rat bladder carcinogenesis. Jpn J Cancer Res, 82: 1077-1084, 1991.

23. Shirai, T., Joong, KD., Hakoi, K., Thamavit, W., Pairojkul, C., Hoshiya, T., Hasegawa, R., Ito, N.: Promotion of rat hepatocarcinogenesis by praziquantel. Jpn J Cancer Res, 82: 1085-1088, 1991.

24. Hirose, M., Uwagawa, S., Ozaki, K., Takaba, K., Ito, N.: Effects of butylated hydroxyanisole pretreatment on low dose N-methyl-N’-nitro-N-nitrosoguanidine- or N,N-dibutylnitrosamine-induced rat forestomach or esophageal carcinogenesis. Carcinogenesis, 12: 1773-1776, 1991.

25. Hirose, M., Ozaki, K., Takaba, K., Fukushima, S., Shirai, T., Ito, N.: Modifying effects of the naturally occurring antioxidants γ-oryzanol, phytic acid, tannic acid and n-tritriacontane-16,18-dione in a rat wide-spectrum organ carcinogenesis model. Carcinogenesis, 12: 1917-1921, 1991.

26. Mori, S., Murai, T., Takeuchi, Y., Hosono, M., Ohhara, T., Makino, S., Hayashi, Y., Shibata, MA., Kurata, Y., Hagiwara, A., Fukushima, S.: No promotion of urinary bladder carcinogenesis by sodium L-ascorbate in male ODS/Shi-od/od rats lacking L-ascorbic acid-synthesizing ability. Carcinogenesis, 12: 1869-1873, 1991.

27. Shibata, MA., Hirose, M., Tanaka, H., Asakawa, E., Shirai, T., Ito, N.: Induction of renal cell tumors in rats and mice, and enhancement of hepatocellular tumor development in mice after long-term hydroquinone treatment. Jpn J Cancer Res, 82:1211-1219, 1991.

28. Shirai, T., Yamamoto, A., Iwasaki, S., Tamano, S., Masui, T.: Induction of invasive carcinomas of the seminal vesicles and coagulating glands of F344 rats by administration of N-methyl-nitrosourea or N-nitrosobis(2-oxopropyl)amine and followed by testosterone propionate with or without high-fat diet. Carcinogenesis, 12:2169-2173, 1991.

29. Hagiwara, A., Tanaka, H., Tiwawech, D., Shirai, T., Ito, N.: Oral toxicity study of tragacanth gum in B6C3F1 mice: Development of squamous-cell hyperplasia in the forestomach and its reversibility. J Toxicol Environ Health, 34: 207-218, 1991.

30. de Camargo, JLV., Shirai, T., Kato, T., Asamoto, M., Fukushima, S.: Summation effects of uracil and other promoters on epithelial lesion development in the F344 rat urinary bladder initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Jpn J Cancer Res, 82: 1220-1225, 1991.

31. Fukushima, S., Mutai, M., Hasegawa, R., Takahashi, S., de Camargo, JLV., Shirai, T.: Enhancing effects of carcinogens or promoters on bladder carcinogenesis in rats. J Toxicol Pathol, 4: 159-164, 1991.

32. Hagiwara, A., Hirose, M., Takahashi, S., Ogawa, K., Shirai, T., Ito, N.: Forestomach and kidney carcinogenicity of caffeic acid in F344 rats and C57BL/6NxC3H/HeN F1 mice. Cancer Res, 51: 5655-5660, 1991.

33. Murai, T., Mori, S., Hosono, M., Takeuchi, Y., Ohara, T., Makino, S., Takeda, R., Hayashi, Y., Fukushima, S.: Renal pelvic carcinoma which shows metastatic potential to distant organs, induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice. Jpn J Cancer Res, 82: 1371-1377, 1991.

34. Imaida, K., Furihata, C., Tatematsu, M., Yoon, CH., Furukawa, F., Uneyama, C., Takahashi, M., Ito, N., Hayashi, Y.: Immunohistochemical and biochemical identification of pepsinogen isozymes in the hamster lungs: Induction by polychlorinated biphenyls. Toxicol Pathol, 19: 230-236, 1991.

35. Hasegawa, R., Shirai, T., Hakoi, K., Takaba, K., Iwasaki, S., Hoshiya, T., Ito, N., Nagao, M., Sugimara, T.: Synergistic enhancement of glutathione S-transferase placental form-positive hepatic foci development in diethylnitrosamine-treated rats by combined administration of five heterocyclic amines at low doses. Jpn J Cancer Res, 82: 1378-1384, 1991.

36. Uwagawa, S., Tsuda, H., Inoue, T., Tagawa, Y., Aoki, T., Kagawa, M., Ogiso, T., Ito, N.: Enhancing potential of 6 different carcinogens on multi-organ tumorigenesis after initial treatment with N-methyl-N-nitrosourea in rats. Jpn J Cancer Res, 82:1397-1405, 1991.

37. Thamavit, W., Moore, MA., Ruchirawat, S., Ito, N.: Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver. Cancer Lett, 61:229-232, 1991.

38. Cabral, R., Hoshiya, T., Hakoi, K., Hasegawa, R., Fukushima, S., Ito, N.: A rapid in vivo bioassay for the carcinogenicity of pesticides. Tumori, 77: 185-188, 1991.

39. Shibata, MA., Kagawa, M., Kawabe, M., Hagiwara, A., Fukushima, S.: Comparative promoting activities of phosphate salts on rat two-stage bladder carcinogenesis under conditions of equivalent urinary Na+ or K+ levels. Teratog Carcinog Mutagen, 11: 305-316, 1991.

40. Ito, N., Shirai, T., Fukushima, S.: Medium-term bioassay for carcinogens using multiorgan models. In: Ito, N. & Sugano, H. (eds.) Modification of Tumor Development in Rodents, Vol. 33, pp.41-57. S. Karger, Basel, 1991.

41. Fukushima, S. Modification of tumors development in the urinary bladder. In: Ito, N. & Sugano, H. (eds.) Modification of Tumor Development in Rodents, Vol. 33, pp.154-174. S. Karger, Basel, 1991.

42. Ito, N., Shirai, T.: Tumors of the accessory male sex organs. In: Turusov, V. & Mohr, U. (eds.) Pathology of Tumours in Laboratory Animals, Vol.1, pp421-443. International Agency for Research on Cancer, Lyon, 1991.

43. Tsuda, H., Ozaki, K., Uwagawa, S., Takahashi, S., Hakoi, K., Kato, T., Fukushima, S., Sato, K., Ito, N.: Analysis of the effects of modifying agents on proliferation and enzyme phenotype in focal preneoplastic and neoplastic liver lesions in rats. In: Columbano, A. et al. (eds.) Chemical Carcinogenesis 2, pp219-229. Plenum Press, New York, 1991.

44. Moore, MA., Thamavit, W., Tiwawech, D., Ito, N.: Cell death and proliferation in Opisthorchis viverrini-DHPN induced carcinogenesis in the Syrian hamster hepato-pancreatic axis. In: Columbano, A. et al. (eds.) Chemical Carcinogenesis 2, pp502-510. Plenum Press, New York, 1991.

45. Fukushima, S., de Camargo, JLV, Asamoto, M., Hasegawa, R., Tsuda, H.: Amplifying effects of uracil on multi-stage bladder carcinogenesis in rats. In: Columbano, A. et al. (eds.) Chemical Carcinogenesis 2, pp611-618. Plenum Press, New York, 1991.

46. Ito, N., Hirose, M., Takahashi, S.: Cellular proliferation and stomach carcinogenesis induced by antioxidants. In: Butterworth, BE. et al. (eds.) Chemically Induced Cell Proliferation: Implications for Risk Assessment, pp43-52. Wiley-Liss, Inc., New York, 1991.

47. Fukushima, S., Shibata, MA., Kurata, Y., Hasegawa, R.: The roles of L-ascorbic acid, urinary pH, and Na or K ion concentration in rat bladder epithelial cell proliferation with special reference to tumor promotion. In: Butterworth, BE. et al. (eds.) Chemically Induced Cell Proliferation: Implications for Risk Assessment, pp195-208. Wiley-Liss, Inc., New York, 1991.

48. Tatematsu, M., Shirai, T., Ogawa, K., Asamoto, M., Ito, N.: Proliferation kinetics and development of pepsinogen-altered pyloric gland cells in the glandular stomach of rats treated with chemicals. In: Butterworth, BE. et al. (eds.) Chemically Induced Cell Proliferation: Implications for Risk Assessment, pp445-455. Wiley-Liss, Inc., New York, 1991.

1. Hirose, M., Masuda, A., Hasegawa, R., Wada, S., Ito, N.: Regression of butylated hydroxyanisole (BHA)-induced hyperplasia but not dysplasia in the forestomach of hamsters. Carcinogenesis, 11: 239-244, 1990.

2. Shibata, MA., Hasegawa, R., Kurata, Y., Yamada, M., Tamano, S., Fukushima, S.: Bladder epithelial hyperplasia in F344 rats after intravesical instillation of the antitumor chemotherapeutic agents Adriamycin and mitomycin C. Cancer Lett, 49: 41-49, 1990.

3. Mutai, M., Tatematsu, M., Aoki, T., Wada, S., Ito, N.: Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development. Cancer Lett, 49: 127-132, 1990.

4. Mori, S., Murai, T., Takeuchi, Y., Toyama, M., Makino, S., Konishi, T., Hayashi, Y., Kurata, Y., Fukushima, S.: Dose response of N-butyl-N-(4-hydroxybutyl)nitrosamine on urinary bladder carcinogenesis in mutant ODS rats lacking L-ascorbic acid synthesizing ability. Cancer Lett, 49: 139-145, 1990.

5. Shibata, MA., Yamada, M., Hirose, M., Asakawa, E., Tatematsu, M., Ito, N.: Early proliferative responses of forestomach and glandular stomach of rats treated with five different phenolic antioxidants. Carcinogenesis, 11: 425-429, 1990.

6. Hagiwara, A., Tanaka, H., Kurata, Y., Kato, T., Tsuda, H., Ito, N.: Lack of hepatotoxicity or promotion of enzyme-altered liver foci development in rats treated with harman or norharman. J Toxicol Environ Health, 29: 211-218, 1990.

7. Hirose, M., Fukushima, S., Shirai, T., Hasegawa, R., Kato, T., Tanaka, H., Asakawa, E., Ito, N.: Stomach carcinogenicity of caffeic acid, sesamol and catechol in rats and mice. Jpn J Cancer Res, 81: 207-212, 1990.

8. Shirai, T., Nakamura, A., Fukushima, S., Wang, CY., Yamada, H., Ito, N.: Selective induction of prostate carcinomas in F344 rats treated with intraperitoneal injections of N-hydroxy-3,2′-dimethyl-4-aminobiphenyl. Jpn J Cancer Res, 81:320-323, 1990.

9. Tsuda, H., Takahashi, S., Yamaguchi, S., Ozaki, K., Ito, N.: Comparison of initiation potential of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in an in vivo carcinogen bioassay system. Carcinogenesis, 11: 549-552, 1990.

10. Ogiso, T., Tatematsu, M., Tamano, S., Hasegawa, R., Ito, N.: Correlation between medium-term liver bioassay system data and results of long-term testing in rats. Carcinogenesis, 11: 561-566, 1990.

11. Shirai, T., Nakamura, A., Fukushima, S., Tada, M., Morita, T., Ito, N.: Immunohistochemical demonstration of carcinogen-DNA adducts in target and non-target tissues of rats given a prostate carcinogen, 3,2′-dimethyl-4-aminobiphenyl. Carcinogenesis, 11: 653-657, 1990.

12. Hirose, M., Masuda, A., Ito, N., Kamano, K., Okuyama, H.: Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats. Carcinogenesis, 11: 731-735, 1990.

13. Shirai, T., Nakamura, A., Fukushima, S., Yamamoto, A., Tada, M., Ito, N.: Different carcinogenic responses in a variety of organs, including the prostate, of five different rat strains given 3,2′-dimethyl-4-aminobiphenyl. Carcinogenesis, 11: 793-797, 1990.

14. Hasegawa, R., Takahashi, S., Asamoto, M., Shirai, T., Fukushima, S.: Species differences in sodium o-phenylphenate induction of urinary bladder lesions. Cancer Lett, 50: 87-91, 1990.

15. Asamoto, M., Hasegawa, R., Masuko, T., Hashimoto, Y., Ueda, K., Ohtaguro, K., Sasaki, S., Washida, H., Fukushima, S.: Immunohistochemical analysis of c-erbB-2 oncogene product and epidermal growth factor receptor expression in human urinary bladder carcinomas. Acta Pathol Jpn, 40: 322-326, 1990.

16. Shibata, MA., Hirose, M., Yamada, M., Tatematsu, M., Uwagawa, S., Ito, N.: Epithelial cell proliferation in rat forestomach and glandular stomach mucosa induced by catechol and analogous dihydroxybenzenes. Carcinogenesis, 11: 997-1000, 1990.

17. Shibata, MA., Fukushima, S., Takahashi, S., Hasegawa, R., Ito, N.: Enhancing effects of sodium phenobarbital and N,N-dibutylnitrosamine on tumor development in a rat wide-spectrum organ carcinogenesis model. Carcinogenesis, 11: 1027-1031, 1990.

18. Hagiwara, A., Kurata, Y., Tamano, S.: Ectopic intestinal glands in the forestomach of a F344 rat. Vet Pathol, 27: 201-203, 1990.

19. Tatematsu, M., Ichinose, M., Miki, K., Hasegawa, R., Kato, T., Ito, N.: Gastric and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry. Acta Pathol Jpn, 40: 494-504,1990.

20. Masui, T., Asamoto, M., Hasegawa, R., Kagawa, M., Fukushima, S.: Effects of monosodium succinate, disodium succinate, and succinic acid on urinary bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)- nitrosamine-initiated, unilaterally ureter-ligated rats. J Toxicol Pathol, 3: 105-110, 1990.

21. Cova, L., Wild, CP., Mehrotra, R., Turusov, V., Shirai, T., Lambert, V., Jacquet, C., Tomatis, L., Trepo, C., Montesano, R.: Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumors in ducks. Cancer Res, 50: 2156-2163, 1990.

22. Fukushima, S., Uwagawa, S., Shirai, T., Hasegawa, R., Ogawa, K.: Synergism by sodium L-ascorbate but inhibition by L-ascorbic acid for sodium saccharin promotion of rat two-stage bladder carcinogenesis. Cancer Res, 50: 4195-4198, 1990.

23. Kurata, Y., Fukushima, S., Hasegawa, R., Hirose, M., Shibata, MA., Shirai, T., Ito, N.: Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxidants. Jpn J Cancer Res, 81: 754-759, 1990.

24. Tatematsu, M., Katsuyama, T., Furihata, C., Fukushima, S., Shirai, T., Kato, T., Ito, N.: Cellular differentiation and histogenesis of rat glandular stomach cancers. Jpn J Cancer Res, 81: 760-767, 1990.

25. Hagiwara, A., Tamano, S., Shibata, MA., Arai, M., Tsuda, H.: Lack of modifying effects of p-phenylenediamine on induction of γ-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats. Toxicol Lett, 52: 261-268, 1990.

26. Hirose, M., Fukushima, S., Hasegawa, R., Kato, T., Tanaka, H., Ito, N.: Effects of sodium nitrite and catechol or 3-methoxycatechol in combination on rat stomach epithelium. Jpn J Cancer Res, 81: 857-861, 1990.

27. Hasegawa, R., Furukawa, F., Toyoda, K., Takahashi, M., Hayashi, Y., Hirose, M., Ito, N.: Inhibitory effects of antioxidants on N-bis(2-hydroxypropyl)nitrosamine-induced lung carcinogenesis in rats. Jpn J Cancer Res, 81: 871-877, 1990.

28. Nakamura, A., Shirai, T., Ogawa, K., Wada, S., Fujimoto, NA., Ito, A., Ito, N.: Promoting action of prolactin released from a grafted transplantable pituitary tumor (MtT/F84) on rat prostate carcinogenesis. Cancer Lett, 53: 151-157, 1990.

29. Hagiwara, A., Yamada, M., Hasegawa, R., Fukushima, S., Ito, N.: Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats. Cancer Lett, 54: 67-73, 1990.

30. Wada, S., Hirose, M., Takahashi, S., Okazaki, S., Ito, N.: Para-methoxyphenol strongly stimulates cell proliferation in the rat forestomach but is not a promoter of rat forestomach carcinogenesis. Carcinogenesis, 11: 1891-1894, 1990.

31. Asamoto, M., Shichino, Y., Tsuda, H., Ito, N.: Inhibition of rat hepatic glutathione S-transferase placental form positive foci development by concomitant administration of antioxidants to carcinogen-treated rats. Cancer Lett, 55: 25-29, 1990.

32. Imaida, K., Hirose, M., Yamaguchi, S., Takahashi, S., Ito, N.: Effects of naturally occurring antioxidants on combined 1,2-dimethylhydrazine- and 1-methyl-1-nitrosourea-initiated carcinogenesis is F344 male rats. Cancer Lett, 55: 53-59, 1990.

33. Tamano, S., Kurata, Y., Kawabe, M., Yamamoto, A., Hagiwara, A., Cabral, R., Ito, N.: Carcinogenicity of captafol in F344 /DuCrj rats. Jpn J Cancer Res, 81: 1222-1231, 1990.

34. Hagiwara, A., Tamano, S., Ogiso, T., Asakawa, E., Fukushima, S.: Promoting effect of the peroxisome proliferator, clofibrate, but not di(2-ethylhexyl)phthalate, on urinary bladder carcinogenesis in F344 rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Jpn J Cancer Res, 81: 1232-1238, 1990.

35. Kurata, Y., Fukushima, S., Hagiwara, A., Ito, H., Ogawa, K., Ito, N.: Carcinogenicity study of methyl hesperidin in B6C3F1 mice. Fd Chem Toxicol, 28: 613-618, 1990.

36. Ichinose, M., Miki, K., Tatematsu, M., Furihata, C., Matsushima, M., Ichihara, Y., Tanji, M., Konishi, T., Obara, M., Inoue, H., Kurokawa, K., Takahashi, T., Kageyama, T., Takahashi, K.: Hydrocortisone-induced enhancement of expression and changes in methylation of pepsinogen genes in stomach mucosa of the developing rat. Biochem Biophys Res Comm, 172: 1086-1093, 1990.

37. Yamaguchi, S., Tatematsu, M., Furihata, C., Takaba, K., Ito, N.: Effects of bile acids on development of pepsinogen-altered pyloric glands in rats. Cancer Lett, 55: 129-134, 1990.

38. Ikawa, E., Tagawa, Y., Shirai, T., Hirose, M., Fukushima, S.: Induction of preneoplastic lesions by sequential treatment of rats with three carcinogens: N-butyl-N-(4-hydroxybutyl)nitrosamine, 7,12-dimethylbenz(a)anthracene, and N-methyl-N-nitro-N-nitrosoguanidine. J Toxicol Pathol, 4: 63-66, 1990.

39. Moore, MA., Thamavit, W., Tiwawech, D., Ito, N.: Absence of any enhancing effect of concomitant administration of 3-aminobenzamide on propylnitrosamine induction of tumour development in F344 rats and Syrian golden hamsters. Thai Cancer J, 16: 79-83, 1990.

40. Okamura, T., Tsugaya, M., Watase, H., Ueda, K., Hasegawa, R., Fukushima, S., Ohtaguro, K.: Various urinary properties in bladder tumor patients. Jpn J Clin Oncol, 20: 154-158, 1990.

41. Ito, N., Hirose, M., Hagiwara, A., Takahashi, S.: Carcinogenicity and modification of carcinogenic response by antioxidants. In: Kuroda, Y., Shankel, DM. & Waters, MD. (eds.) Antimutagenesis and Anticarcinogenesis Mechanisms II, pp183-194. Plenum Publishing Co., 1990.

42. Ito, N., Shirai, T., Thamavit, W., Pairojkul, C.: Opisthorchis viverrini and liver tumors in northeastern Thailand. In: Sasaki, R. & Aoki, K. (eds.) Epidermiology & Prevention of Cancer, pp60-65. Univ. Nagoya Press, Nagoya, 1990.

43. Fukushima, S., Shibata, MA., Shirai, T., Hasegawa, R.: Cancer and vitamin C. In: Fujita, T., Fukase, M. & Konishi, T. (eds.) Vitamin C and the Scurvy-Prone ODS Rat, pp211-222. Elsevier Science Publishers B.V. (Biomedical Division), 1990.

44. Mori, S., Murai, T., Toyama, M., Takeuchi, Y., Makino, S., Konishi, T., Hayashi, Y., Kurata, Y., Fukushima, S.: Urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine in ODS rats. In: Fujita, T., Fukase, M. & Konishi, T. (eds.) Vitamin C and the Scurvy-Prone ODS Rat, pp223-235. Elsevier Science Publishers B.V. (Biomedical Division), 1990.

45. Tsuda, H., Asamoto, M., Kagawa, M., de Camargo, JLV., Ito, N., Nagase, S.: Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of rat hepatocarcinogenesis in a medium-term bioassay system. In: Fujita, T., Fukase, M. & Konishi, T. (eds.) Vitamin C and the Scurvy-Prone ODS Rat, pp237-245. Elsevier Science Publishers B.V. (Biomedical Division), 1990.

46. Tada, M., Kojima, M., Shirai, T., Ito, N., Morita, T.: Immunological detection and quantitation of carcinogen-DNA adducts. In: Vanderlaan, M. et al. (eds.) Immunoassays for Trace Chemical Analysis, Vol. 451, pp246-256. American Chemical Society, Washington, DC, 1990.

1. Shirai, T., Fukushima, S., Tagawa, Y., Okumura, M., Ito, N.: Cell proliferation induced by uracil-calculi and subsequent development of reversible papillomatosis in the rat urinary bladder. Cancer Res, 49: 378-383, 1989.

2. Thornton, M., Moore, MA., Ito, N.: Modifying influence of dehydroepiandrosterone or butylated hydroxytoluene treatment on initiation and development stages of azaserine-induced acinar pancreatic preneoplastic lesions in the rat. Carcinogenesis, 10: 407-410, 1989.

3. Hasegawa, R., Fukushima, S., Hagiwara, A., Masui, T., Masuda, A., Ito, N.: Long-term feeding study of N,N’-diphenyl-p-phenylenediamine in F344 rats. Toxicology, 54: 69-78, 1989.

4. Tsuda, H., Inoue, T., Asamoto, M., Fukushima, S., Ito, N., Okamura, T., Ohtaguro, K., Washida, H., Satoh, K., Amelizad, Z., Oesch, F.: Comparison of enzyme phenotypes in human bladder tumours and experimentally induced hyperplastic and neoplastic lesions of the rat urinary bladder. Virchows Arch B Cell Pathol, 56: 307-316, 1989.

5. Asamoto, M., Fukushima, S., Tatemoto, Y., Yamada, K., Fukui, S., Mori, M.: Immunohistochemical expression of keratin proteins in urinary bladder carcinoma. Pathol Res Pract, 184: 194-201, 1989.

6. Fukushima, S., Asamoto, M., Imaida, K., El-Bolkainy, MN., Tawfik, HN., Ito, N.: Comparative study of urinary bladder carcinomas in Japanese and Egyptians. Acta Pathol Jpn, 39: 176-179, 1989.

7. Ito, N., Fukushima, S.: Promotion of urinary bladder carcinogenesis in experimental animals. Exp Pathol, 36: 1-15, 1989.

8. Shirai, T., Nakamura, A., Fukushima, S., Takahashi, S., Ogawa, K., Ito, N.: Effects of age on multiple organ carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl in rats, with particular reference to the prostate. Jpn J Cancer Res, 80: 312-316, 1989.

9. Ito, N., Hagiwara, A., Tamano, S., Kagawa, M., Shibata, MA., Kurata, Y., Fukushima, S.: Lack of carcinogenicity of quercetin in F344/DuCrj rats. Jpn J Cancer Res, 80: 317-325, 1989.

10. Tatematsu, M., Mutai, M., Aoki, T., de Camargo, JLV., Furihata, C., Ito, N.: Proliferation kinetics of pepsinogen altered pyloric gland cells in rats treated with N-methyl-N’-nitro-N-nitrosoguanidine. Carcinogenesis, 10: 907-911, 1989.

11. Shibata, MA., Hagiwara, A., Tamano, S., Ono, S., Fukushima, S.: Lack of a modifying effect by the diuretic drug furosemide on the development of neoplastic lesions in rat two-stage urinary bladder carcinogenesis. J Toxicol Environ Health, 26: 255-265, 1989.

12. Imaida, K., Tatematsu, M., Kato, T., Tsuda, H., Ito, N.: Advantages and limitations of stereological estimation of placental glutathione S-transferase-positive rat liver cell foci by computerized three-dimensional reconstruction. Jpn J Cancer Res, 80: 326-330, 1989.

13. Hagiwara, A., Tamano, S., Shibata, MA., Arai, M., Tsuda, H.: Lack of modifying effects of 2,2′-[(4-aminophenyl)imino]bisethanol sulfate on induction of preneoplastic γ-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats. J Toxicol Sci, 14: 77-86, 1989.

14. Tatematsu, M., Katsuyama, T., Mutai, M., Asakawa, E., Ito, N.: Pyloric gland phenotypic expression of gastric cancers developing in the rat fundic glandular stomach. Carcinogenesis, 10: 1033-1039, 1989.

15. Shirai, T., Nakamura, A., Wada, S., Ito, N.: Pancreatic acinar cell tumors in rats induced by 3,2′-dimethyl-4-aminobiphenyl. Carcinogenesis, 10: 1127-1130, 1989.

16. Thamavit, W., Fukushima, S., Kurata, Y., Asamoto, M., Ito, N.: Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model. Cancer Lett, 45: 93-101, 1989.

17. Hagiwara, A., Hirose, M., Miyata, Y., Fukushima, S., Ito, N.: Modulation of N-butyl-N-(4-hydroxybutyl)- nitrosamine-induced rat urinary bladder carcinogenesis by post-treatment with combinations of three phenolic antioxidants. J Toxicol Pathol, 2: 33-39, 1989.

18. Tagawa, Y., Shirai, T., Fukushima, S., Nakamura, A., Hirose, M., Ito, N.: Lack of modification by dietary unsaturated fat of 3,2′-dimethyl-4-aminobiphenyl-induced rat prostate and colon carcinogenesis. J Toxicol Pathol, 2: 49-53, 1989.

19. Ito, N., Imaida, K., Hasegawa, R., Tsuda, H.: Rapid bioassay methods for carcinogens and modifiers of hepatocarcinogenesis. Crit Rev Toxicol, 19: 385-415, 1989.

20. Shibata, MA., Yamada, M., Tanaka, H., Kagawa, M., Fukushima, S.: Changes in urine composition, bladder epithelial morphology, and DNA synthesis in male F344 rats in response to ingestion of bladder tumor promoters. Toxicol Appl Pharmacol, 99: 37-49, 1989.

21. Tada, M., Aoki, H., Kojima, M., Morita, T., Shirai, T., Yamada, H., Ito, N.: Preparation and characterization of antibodies against 3,2′-dimethyl-4-aminobiphenyl-modified DNA. Carcinogenesis, 10: 1397-1402, 1989.

22. Shibata, MA., Tamano, S., Kurata, Y., Hagiwara, A., Fukushima, S.: Participation of urinary Na+, K+, pH, and L-ascorbic acid in the proliferative response of the bladder epithelium after the oral administration of various salts and/or ascorbic acid to rats. Fd Chem Toxicol, 27: 403-413, 1989.

23. Asamoto, M., Fukushima, S., Tatemoto, Y., Yamada, K., Yuba, R., Mori, M.: Immunohistochemical evaluation of nonspecific cross reactive antigen and carcinoembryonic antigen (CEA) in urinary bladder carcinoma. Anticancer Res, 9: 319-326, 1989.

24. Hirose, M., Kurata, Y., Yamada, M., Shirai, T., Ito, N., Ohsawa, T.: Lack of modifying effects of linolic acid hydroperoxides and their secondary oxidative products on combined 7,12-dimethylbenz[a]anthracene and 1,2-dimethylhydrazine-initiated mammary gland, ear duct and colon carcinogenesis in female Sprague-Dawley rats. Cancer Lett, 47: 141-147, 1989.

25. Fukushima, S., Inoue, T., Uwagawa, S., Shibata, MA., Ito, N.: Co-carcinogenic effects of NaHCO3 on o-phenylphenol-induced rat bladder carcinogenesis. Carcinogenesis, 10: 1635-1640, 1989.

26. Shibata, MA., Yamada, M., Asakawa, E., Hagiwara, A., Fukushima, S.: Responses of rat urine and urothelium to bladder tumor promoters: possible roles of prostaglandin E2 and ascorbic acid synthesis in bladder carcinogenesis. Carcinogenesis, 10: 1651-1656, 1989.

27. Asamoto, M., Fukushima, S., Oosumi, H., Tatemoto, Y., Mori, M.: Immunohistochemical distribution of epithelial membrane antigen in bladder carcinomas as detected with a monoclonal antibody. Urol Res, 17: 273-277, 1989.

28. Asamoto, M., Fukushima, S., Horike, H., Tatemoto, Y., Mori, M.: Involucrin expression in urinary bladder carcinoma. Urol Res, 17: 279-283, 1989.

29. Kurata, Y., Tamano, S., Shibata, MA., Hagiwara, A., Fukushima, S., Ito, N.: Lack of carcinogenicity of magnesium chloride in a long-term feeding study in B6C3F1 mice. Fd Chem Toxicol, 27: 559-563, 1989.

30. Hirose, M., Yamaguchi, S., Fukushima, S., Hasegawa, R., Takahashi, S., Ito, N.: Promotion by dihydroxybenzene derivatives of N-methyl-N’-nitro-N-nitrosoguanidine-induced F344 rat forestomach and glandular stomach carcinogenesis. Cancer Res, 49: 5143-5147, 1989.

31. Asamoto, M., Tsuda, H., Kagawa, M., de Camargo, JLV., Ito, N., Nagase, S.: Strain differences in susceptibility to 2-acetylaminofluorone and phenobarbital promotion on rat hepatocarcinogenesis in a medium-term assay system: Quantitation of glutathione S-transferase P-positive foci development. Jpn J Cancer Res, 80: 939-944, 1989.

32. Hasegawa, R., Mutai, M., Imaida, K., Tsuda, H., Yamaguchi, S., Ito, N.: Synergistic effects of low-dose hepatocarcinogens in induction of glutathione S-transferase P-positive foci in the rat liver. Jpn J Cancer Res, 80: 945-951, 1989.

33. Satoh, K., Hatayama, I., Tateoka, N., Tamai, K., Shimizu, T., Tatematsu, M., Ito, N., Sato, K.: Transient induction of single GST-P positive hepatocytes by DEN. Carcinogenesis, 10: 2107-2111, 1989.

34. Ito, N., Hirose, M.: Antioxidants. Carcinogenic and chemopreventive properties. Adv Cancer Res, 53: 247-302, 1989.

35. Tatematsu, M., Mutai, M., Inoue, K., Ozaki, K., Furihata, C., Ito, N.: Synergism between sodium chloride and sodium taurocholate and development of pepsinogen-altered pyloric glands: Relevance to a medium-term bioassay system for gastric carcinogens and promoters in rats. Jpn J Cancer Res, 80: 1035-1040, 1989.

36. Asamoto, M., Tsuda, H., Kato, T., Ito, N., Masuko, T., Hashimoto, Y., Nagase, S.: Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: Immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital. Jpn J Cancer Res, 80: 1041-1046, 1989.

37. Shibata, MA., Tanaka, H., Yamada, M., Tamano, S., Fukushima, S.: Proliferative response of renal pelvic epithelium in rats to oral administration of ortho-phenylphenol, sodium ortho-phenylphenate and diphenyl. Cancer Lett, 48: 19-28, 1989.

38. Yamaguchi, S., Hirose, M., Fukushima, S., Hasegawa, R., Ito, N.: Modification by catechol and resorcinol of upper digestive tract carcinogenesis in rats treated with methyl-N-amylnitrosamine. Cancer Res, 49: 6015-6018, 1989.

39. Hirose, M., Kagawa, M., Ogawa, K., Yamamoto, A., Ito, N.: Antagonistic effect of diethylmaleate on the promotion of forestomach carcinogenesis by butylated hydroxyanisole (BHA) in rats pretreated with N-methyl-N’-nitro-N-nitrosoguanidine. Carcinogenesis, 10: 2223-2226, 1989.

40. Hosokawa, S., Tatematsu, M., Aoki, T., Nakanowatari, J., Igarashi, T., Ito, N.: Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator. Carcinogenesis, 10: 2237-2241, 1989.

41. Ito, N., Hirose, M., Shibata, MA., Tanaka, H., Shirai, T.: Modifying effects of simultaneous treatment with butylated hydroxyanisole (BHA) on rat tumor induction by 3,2′-dimethyl-4-aminobiphenyl, 2,2′-dihydroxy-di-n-propylnitrosamine and N-methylnitrosourea. Carcinogenesis, 10: 2255-2259, 1989.

42. de Camargo, JLV., Tsuda, H., Tatematsu, M., Rodrigues, MAM., Yamada, M.,Tzuji, K., Ito, N.: Placental form of glutathione S-transferase in normal and diseased human uterine cervical mucosa. Carcinogenesis, 10: 2317-2320, 1989.

43. Saito, K., Nakagawa, S., Yoshitake, A., Miyamoto, J., Hirose, M., Ito, N.: DNA-adduct formation in the forestomach of rats treated with 3-tert-butyl-4-hydroxyanisole and its metabolites as assessed by an enzymatic 32P-postlabeling method. Cancer Lett, 48: 189-195, 1989.

44. Fitzgerald, DJ., Mesnil, M., Oyamada, M., Tsuda, H., Ito, N., Yamasaki, H.: Changes in gap junction protein (connexin 32) gene expression during rat liver carcinogenesis. J Cell Biochem, 41: 97-102, 1989.

45. Ito, N., Tatematsu, M., Hasegawa, R., Tsuda, H.: Medium-term bioassay system for detection of carcinogens and modifiers of hepatocarcinogenesis utilizing the GST-P positive liver cell focus as an endpoint marker. Toxicol Pathol, 17: 630-641, 1989.

46. Tatematsu, M., Ozaki, K., Mutai, M., Shichino, Y., Furihata, C., Ito, N.: Enhancing effects of various gastric carcinogens on development of pepsinogen-altered pyloric glands in rats. Carcinogenesis, 11: 1975-1978, 1989.

47. Ito, N., Fukushima, S., Hasegawa, R.: Bladder Cancers. Their process of development and its modification. Acta Pathol Jpn, 39: 1-14, 1989.

48. Ward, JM., Tsuda, H., Tatematsu, M., Hagiwara, A., Ito, N.: Hepatotoxicity of agents that enhance formation of focal hepatocellular proliferative lesions (putative preneoplastic foci) in a rapid rat liver bioassay. Fundam Appl Toxicol, 12: 163-171, 1989.

49. Ito, N., Tsuda, H., Hasegawa, R., Tatematsu, M., Imaida, K., Asamoto, M.: Medium-term bioassay models for environmental carcinogens. Two-step liver and multi-organ carcinogenesis protocols. In: Travis, CC. (ed.) Biologically-Based Methods for Cancer Risk Assessment, pp209-230. Plenum Publishing Co., 1989.

50. Shirai, T., Ito, N.: Rat prostatic carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl. In: Karr, JP. & Yamanaka, H. (eds.) Prostate cancer. The Second Tokyo Symposium, pp77-85: Elsevier Sci. Pub. Co. Inc., 1989.

1. Hirose, M., Masuda, A., Fukushima, S., Ito, N.: Effects of subsequent antioxidant treatment on 7,12-dimethylbenz[a]anthracene-initiated carcinogenesis of the mammary gland, ear duct and forestomach in Sprague-Dawley rats. Carcinogenesis, 9: 101-104, 1988.

2. Tatematsu, M., Mera, Y., Inoue, T., Satoh, K., Sato, K., Ito, N.: Stable phenotypic expression of glutathione S-transferase placental type and unstable phenotypic expression of γ-glutamyltransferase in rat liver preneoplastic and neoplastic lesions. Carcinogenesis, 9: 215-220, 1988.

3. Tatematsu, M., Aoki, T., Kagawa, M., Mera, Y., Ito, N.: Reciprocal relationship between development of glutathione S-transferase positive liver foci and proliferation of surrounding hepatocytes in rats. Carcinogenesis, 9: 221-225, 1988.

4. Masui, T., Shirai, T., Imaida, K., Uwagawa, S., Fukushima, S.: Effects of urinary crystals induced by acetazolamide, uracil, and diethylene glycol on urinary bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated rats. Toxicol Lett, 40: 119-126, 1988.

5. Ito, N., Tsuda, H., Tatematsu, M., Inoue, T., Tagawa, Y., Aoki, T., Uwagawa, S., Kagawa, M., Ogiso, T., Masui, T., Imaida, K., Fukushima, S., Asamoto, M.: Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rat — an approach for a new medium-term bioassay system. Carcinogenesis, 9: 387-394, 1988.

6. Tatematsu, M., Aoki, T., Inoue, T., Mutai, M., Furihata, C., Ito, N.: Coefficient induction of pepsinogen 1-decreased pyloric glands and gastric cancers in five different strains of rats treated with N-methyl-N’-nitro-N-nitrosoguanidine. Carcinogenesis, 9: 495-498, 1988.

7. Hayashi, M., Tsuda, H., Okumura, M., Sakata, T., Ito, N., Suchi, T.: Histopathological classification of malignant lymphomas in slaughtered swine. J Comp Pathol, 98: 11-21, 1988.

8. Shirai, T., Yamamoto, K., Adachi, T., Imaida, K., Masui, T., Ito, N.: Condyloma acuminatum of the bladder in two autopsy cases. Acta Pathol Jpn, 38: 399-405, 1988.

9. Mori, S., Takeuchi, Y., Toyama, M., Makino, S., Harauchi, T., Kurata, Y., Fukushima, S.: Assessment of L-ascorbic acid requirement for prolonged survival in ODS rats and their susceptibility to urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett, 38: 275-282, 1988.

10. Tsuda, H., Moore, MA., Asamoto, M., Inoue, T., Ito, N., Satoh, K., Ichihara, A., Nakamura, T., Amelizad, Z., Oesch, F.: Effect of modifying agents on the phenotypic expression of cytochrome P-450, glutathione S-transferase molecular forms, microsomal epoxide hydrolase, glucose-6-phosphate dehydrogenase and γ-glutamyltranspeptidase in rat liver preneoplastic lesions. Carcinogenesis, 9: 547-554, 1988.

11. Nakanowatari, JI., Fukushima, S., Imaida, K., Ito, N., Nagase, S.: Strain differences in N-butyl-N-(4-hydroxybutyl)nitrosamine bladder carcinogenesis in rats. Jpn J Cancer Res (Gann), 79: 453-459, 1988.

12. Ito, N., Imaida, K., Tsuda, H., Shibata, MA., Aoki, T., de Camargo, JLV., Fukushima, S.: Wide-spectrum initiation models: possible applications to medium-term multiple organ bioassays for carcinogenesis modifiers. Jpn J Cancer Res (Gann), 79: 413-417, 1988.

13. Shirai, T., Masuda, A., Imaida, K., Ogiso, T., Ito, N.: Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-Bis(2-hydroxypropyl)nitrosamine. Jpn J Cancer Res (Gann), 79: 460-465, 1988.

14. Masui, T., Asamoto, M., Imaida, K., Fukushima, S., Okamura, T., Ohtaguro, K.: Primary choriocarcinoma of the urinary bladder. Jpn J Clin Oncol, 18: 59-64, 1988.

15. Ito, N., Imaida, K., de Camargo, JLV., Takahashi, S., Asamoto, M., Tsuda, H.: A new medium-term bioassay system for detection of environmental carcinogens using diethylnitrosamine-initiated rat liver followed by D-galactosamine treatment and partial hepatectomy. Jpn J Cancer Res (Gann), 79: 573-575, 1988.

16. Thamavit, W., Moore, MA., Hiasa, Y., Ito, N.: Enhancement of DHPN induced hepatocellular, cholangiocellular and pancreatic carcinogenesis by Opisthorchis viverrini infestation in Syrian golden hamsters. Carcinogenesis, 9: 1095-1098, 1988.

17. Tsuda, H., Asamoto, M., Kagawa, M., Uwagawa, S., Inoue, K., Inui, M., Ito, N.: Positive influence of dietary deoxycholic acid on development of pre-neoplastic lesions initiated by N-methyl-N-nitrosourea in rat liver. Carcinogenesis, 9: 1103-1105, 1988.

18. Ichinose, M., Miki, K., Tatematsu, M., Furihata, C., Nobuhara, M., Ichihara, Y., Tanji, M., Sogawa, K., Fujii-Kuriyama, Y., Oka, H., Takahashi, T., Kageyama, T., Takahashi, K.: Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach. Biochem Biophys Res Commun, 151: 275-282, 1988.

19. Ichinose, M., Miki, K., Furihata, C., Tatematsu, M., Ichihara, Y., Ishihara, T., Katsura, I., Sogawa, K., Fujii-Kuriyama, Y., Tanji, M., Oka, H., Matsushima, T., Takahashi, K.: DNA methylation and expression of the rat pepsinogen gene in embryonic, adult, and neoplastic tissues. Cancer Res, 48: 1603-1609, 1988.

20. Sumitomo, S., Tatemoto, Y., Tanimura, T., Mori, M., Nakamura, T., Fukushima, S., Ito, N.: Immunohistochemical identification of keratin, involucrin, and epithelial membrane antigen in Paget’s disease. Acta Histochem Cytochem, 21: 61-72, 1988.

21. Tsuda, H., Asamoto, M., Ogiso, T., Inoue, T., Ito, N., Nagao, M.: Does-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low does 3′-methyl-4-dimethylaminoazobenzene promotion. Jpn J Cancer Res (Gann), 79: 691-697, 1988.

22. Inoue, T., Imaida, K., Suzuki, E., Okada, M., Fukushima, S.: Combined effects of L-ascorbic acid, citric acid or their sodium salts on tumor induction by N-butyl-N-(4-hydroxybutyl)nitrosamine or N-ethyl-N-(4-hydroxybutyl)nitrosamine in the rat urinary bladder. Cancer Lett, 40: 265-273, 1988.

23. Masui, T., Fukushima, S., Katoh, F., Yamasaki, H., Ito, N.: Effects of sodium L-ascorbate, uracil, butylated hydroxyanisole and extracellular pH on junctional intercellular communication of BALB/c 3T3 cells. Carcinogenesis, 9: 1143-1146, 1988.

24. Moore, MA., Thamavit, W., Hiasa, Y., Ito, N.: Early lesions induced by DHPN in Syrian golden hamsters: influence of concomitant Opisthorchis infestation, dehydroepiandrosterone or butylated hydroxyanisole administration. Carcinogenesis, 9: 1185-1189, 1988.

25. Fukushima, S., Tamano, S., Shibata, MA., Kurata, Y., Hirose, M., Ito, N.: The role of urinary pH and sodium ion concentration in the promotion stage of two-stage carcinogenesis of the rat urinary bladder. Carcinogenesis, 9: 1203-1206, 1988.

26. Tatematsu, M., Ichinose, M., Miki, K., Tatematsu, K., Kishikawa, H., Ito, N.: Gastric phenotypic expression in human gallbladder cancers revealed by pepsinogen immunohistochemistry and mucin histochemistry. Virchow Archiv A Pathol Anat, 413: 25-32, 1988.

27. Thamavit, W., Moore, MA., Hiasa, Y., Ito, N.: Generation of high yields of Syrian hamster cholangiocellular carcinomas and hepatocellular nodules by combined nitrite and aminopyrine administration and Opisthorchis viverrini infection. Jpn J Cancer Res (Gann), 79: 909-916, 1988.

28. Ito, N., Shirai, T., Tagawa, Y., Nakamura, A., Fukushima, S.: Variation in tumor yield in the prostate and other target organs of the rat in response to varied dosage and duration of administration of 3,2′-dimethyl-4-aminobiphenyl. Cancer Res, 48: 4629-4632, 1988.

29. Ward, JM., Ito, N.: Development of new medium-term bioassays for carcinogens. Cancer Res, 48: 5051-5054, 1988.

30. Hirose, M., Fukushima, S., Kurata, Y., Tsuda, H., Tatematsu, M., Ito, N.: Modification of N-methyl-N’-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats. Cancer Res., 48: 5310-5315, 1988.

31. Masui, T., Shirai, T., Takahashi, S., Mutai, M., Fukushima, S.: Summation effect of uracil on the two-stage and multistage models of urinary bladder carcinogenesis in F344 rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 9: 1981-1985, 1988.

32. Tamano, S., Hagiwara, A., Shibata, MA., Kurata, Y., Fukushima, S., Ito, N.: Spontaneous tumors in aging (C57BL/6N×C3H/HeN)F1 (B6C3F1) mice. Toxicol Pathol, 16: 321-326, 1988.

33. Fukushima, S., Imaida, K., Shibata, MA., Tamano, S., Kurata, Y., Shirai, T.: L-ascorbic acid amplification of second-stage bladder carcinogenesis promotion by NaHCO3. Cancer Res, 48: 6317-6320, 1988.

34. Hirose, M., Hagiwara, A., Inoue, K., Ito, N., Kaneko, H., Saito, K., Matsunaga, H., Isobe, N., Yoshitake, A., Miyamoto, J.: Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole in the rat (III): Metabolites in the urine and feces. Toxicology, 53: 33-43, 1988.

35. Kitagawa, Y., Sakai, R., Tahira, T., Tsuda, H., Ito, N., Sugimura, T., Nagao, M.: Molecular cloning of rat phosphoprotein phosphatase 2Aβ cDNA and increased expressions of phosphatase 2Aα and 2Aβ in rat liver tumors. Biochem Biophys Res Commmun, 157: 821-827, 1988.

36. Shirai, T., Tagawa, Y., Taguchi, O., Ikawa, E., Mutai, M., Fukushima, S., Ito, N.: Low tumorigenic response to 3,2′-dimethyl-4-aminobiphenyl administration in the prostate of rats castrated at birth. Jpn J Cancer Res (Gann), 79: 1293-1296, 1988.

37. Imaida, K., Fukushima, S., Inoue, K., Masui, T., Hirose, M., Ito, N.: Modifying effects of concomitant treatment with butylated hydroxyanisole or butylated hydroxytoluene on N,N-dibutylnitrosamine-induced liver, forestomach and urinary bladder carcinogenesis in F344 male rats. Cancer Lett, 43: 167-172, 1988.

38. Ichinose, M., Miki, K., Tatematsu, M., Mizuno, T., Mutai, M., Furihata, C., Ichihara, Y., Ishihara, T., Tanji, M., Oka, H., Hinohara, Y., Takahashi, T., Kageyama, T., Takahashi, K.: Cell-specific hypomethylation of the pepsinogen gene in pepsinogen-producing cells. Biochem Biophys Res Commmun, 155: 670-677, 1988.

39. Yamada, H., Shirai, T., Ito, N., Wang, CY.: Species- and strain-specific O-acetylation of N-hydroxy-3,2′-dimethyl-4-aminobiphenyl by liver and prostate cytosol. In: King, CM., Romano, LJ., Schuetzle, D. (eds.) Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes, pp.223-226. Elsevier Science Publishing Co. Inc., 1988.

40. Wang, CY., Zukowski, K., Imaida, K., Lee, MS.: Effects of arylamine urinary metabolites on urothelial cells. In: King, CM., Romano, LJ., Schuetzle, D. (eds.) Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes, pp227-236. Elsevier Science Publishing Co. Inc., 1988.

41. Ito, N., Tsuda, H., Masui, T.: In vivo promotion assay of four compounds on enhancement of the development of γ-glutamyl transpeptidase-positive liver cell foci in male F344 rats. In: Ashby, J. et al (eds.) Evaluation of Short-term Tests for Carcinogens, Vol.1, pp1334-1337. Cambridge University Press, New York, 1988.

42. Tsuda, H., Uwagawa, S., Aoki, T., Fukushima, S., Imaida, K., Ito, N., Sato, K., Nakamura, T., Oesch, F.: Analysis of the effects of modifying agents on six different phenotypes in preneoplastic foci in the liver in medium-term bioassay model in rats. In: Feo, F. et al. (eds.) Chemical Carcinogenesis, pp399-405: Plenum Publishing Co., 1988.

43. Ito, N., Tsuda, H., Tatematsu, M., Imaida, K., Kagawa, M., Nakamura, A.,Yamaguchi, S., Mutai, M.: Development and application of an in vivo medium-term bioassay system for the screening of hapatocarcinogens and inhibiting agents of hepatocarcinogenesis. In: Feo, F.et al. (eds.) Chemical Carcinogenesis, pp425-432: Plenum Publishing Co., 1988.

1. Fukushima, S., Ogiso, T., Kurata, Y., Hirose, M., Ito, N.: Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin for promotion of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats. Cancer Lett, 34: 83-90, 1987.

2. Tatematsu, M., Furihata, C., Miki, K., Ichinose, M., Shirai, T., Tatematsu, K., Ito, N.: Complete and incomplete pyloric gland metaplasia of human gallbladder. Acta Pathol Jpn, 37: 39-46, 1987.

3. Hirose, M., Hagiwara, A., Inoue, K., Sakata, T., Ito, N., Kaneko, H., Yoshitake, A., Miyamoto, J.: Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat (I): Excretion of BHA in urine, feces and expired air and distribution of BHA in the main organs. Toxicology, 43: 139-147, 1987.

4. Shirai, T., Tsuda, H., Ogiso, T., Hirose, M., Ito, N.: Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens. Carcinogenesis, 8: 115-119, 1987.

5. Moore, MA., Tsuda, H., Thamavit, W., Masui, T., Ito, N.: Differential modification of development of preneoplastic lesions in the Syrian golden hamster initiated with a single does of 2,2′-dioxo-N-nitrosodipropylamine: Influence of subsequent butylated hydroxyanisole, α-tocopherol, or carbazole. J Natl Cancer Inst, 78: 289-293, 1987.

6. Moore, MA., Thamavit, W., Ito, N.: Comparison of lesions induced in the Syrian golden hamster by diethylnitrosamine, dimethylhydrazine, and dibutylnitrosamine: Influence of subsequent butylated hydroxyanisole treatment. J Natl Cancer Inst, 78: 295-301, 1987.

7. Tsuda, H., Mera, Y., Seki, K., Aoki, T., Fukushima, S., Ito, N.: Induction of tumors in the liver, urinary bladder, esophagus and forestomach by short-term treatment with different doses of N,N’-dibutylnitrosamine in rats. Jpn J Cancer Res (Gann), 78: 227-234, 1987.

8. Shirai, T., Tagawa, Y., Fukushima, S., Asamoto, M., Ito, N.: Lack of tumorigenic response in the prostate gland of castrated F344 rats by 3,2′-dimethyl-4-aminobiphenyl given with methyltestosterone. Cancer Lett, 35: 1-6, 1987.

9. Shirai, T., Ikawa, E., Tagawa, Y., Ito, N.: Lesions of the prostate glands and seminal vesicles induced by N-methylnitrosourea in F344 rats pretreated with ethinyl estradiol. Cancer Lett, 35: 7-15, 1987.

10. Fukushima, S., Ogiso, T., Kurata, Y., Shibata, MA., Kakizoe, T.: Absence of promotion potential for calcium L-ascorbate, L-ascorbic dipalmitate, L-ascorbic stearate and erythorbic acid on rat urinary bladder carcinogenesis. Cancer Lett, 35: 17-25, 1987.

11. Tamano, S., Fukushima, S., Shirai, T., Hirose, M., Ito, N.: Modification by α-tocopherol, propyl gallate and tertiary butylhydroquinone of urinary bladder carcinogenesis in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett, 35: 39-46, 1987.

12. Moore, MA., Bannasch, P., Satoh, T., Hacker, HJ., Ito, N.: Immunohistochemically demonstrated increase in glutathione S-transferase species in propylnitrosamine-induced focal proliferative and neoplastic syrian hamster pancreatic lesions. Virchows Arch [Cell Pathol], 52: 479-488, 1987.

13. Tatematsu, M., Furihata, C., Katsuyama, T., Mera, Y., Inoue, T., Matsushima, T., Ito, N.: Immunohistochemical demonstration of pyloric gland-type cells with low-pepsinogen isozyme 1 in preneoplastic and neoplastic tissues of rat stomachs treated with N-methyl-N’-nitro-N-nitrosoguanidine. J Natl Cancer Inst, 78: 771-777, 1987.

14. Tatematsu, M., Aoki, T., Asamoto, M., Furihata, C., Ito, N.: Enhancing effects of N-ethyl-N’-nitro-N-nitrosoguanidine and sodium taurocholate on development of pepsinogen 1 decreased pyloric glands in rats initiated with N-methyl-N’-nitro-N-nitrosoguanidine. Jpn J
Cancer Res (Gann), 78: 312-316, 1987.

15. Hirose, M., Masuda, A., Imaida, K., Kagawa, M., Tsuda, H., Ito, N.: Induction of forestomach lesions in rats by oral administrations of naturally occurring antioxidants for 4 weeks. Jpn J Cancer Res (Gann), 78: 317-321, 1987.

16. Tatematsu, M., Tsuda, H., Shirai, T., Masui, T., Ito, N.: Placental glutathione S-transferase (GST-P) as a new marker for hepatocarcinogenesis: In vivo short-term screening for hepatocarcinogens. Toxicol Pathol, 15: 60-68, 1987.

17. Tsuda, H., Moore, MA., Asamoto, M., Inoue, T., Fukushima, S., Ito, N., Satoh, K., Amelizad, Z., Oesch, F.: Immunohistochemically demonstrated altered expression of cytochrome P-450 molecular forms and epoxide hydrolase in N-ethyl-N-hydroxyethylnitrosamine-induced rat kidney and liver lesions. Carcinogenesis, 8: 711-717, 1987.

18. Tsuda, H., Ogiso, T., Hasegawa, R., Imaida, K., Masui, T., Ito, N.: Inhibition of neoplastic development in rat liver, kidney, oesophagus and forestomach by 4,4′-diaminodiphenylmethane administration. Carcinogenesis, 8: 719-722, 1987.

19. Furihata, C., Takezawa, R., Matsushima, T., Tatematsu, M.: Potential tumor-promoting activity of bile acids in rat glandular stomach. Jpn J Cancer Res (Gann), 78: 32-39, 1987.

20. Fukushima, S., Sakata, T., Tagawa, Y., Shibata, MA., Hirose, M., Ito, N.: Different modifying response of butylated hydroxyanisole, butylated hydroxytoluene, and other antioxidants in N, N-dibutylnitrosamine esophagus and forestomach carcinogenesis of rats. Cancer Res, 47: 2113-2116, 1987.

21. Hasegawa, R., Fukushima, S., Hirose, M., Seki, K., Takahashi, M., Furukawa, F., Toyoda, K., Ito, N.: Histochemical demonstration of colonic type mucin in glandular metaplasia and adenocarcinoma of the human urinary bladder. Acta Pathol Jpn, 37: 1097-1103, 1987.

22. Hirose, M., Asamoto, M., Hagiwara, A., Ito, N., Kaneko, H., Saito, K., Takamatsu, Y., Yoshitake, A., Miyamoto, J.: Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat (II): Metabolism in forestomach and covalent binding to tissue macromolecules. Toxicology, 45: 13-24, 1987.

23. Funato, T., Yokota, J., Sakamoto, H., Kameya, T., Fukushima, S., Ito, N., Terada, M., Sugimura, T.: Activation of N-ras gene in a rat hepatocellular carcinoma induced by dibutylnitrosamine and butylated hydroxytoluene. Jpn J Cancer Res (Gann), 78: 689-694, 1987.

24. Mori, S., Kurata, Y., Takeuchi, Y., Toyama, M., Makino, S., Fukushima, S.: Influences of strain and diet on the promoting effects of sodium L-ascorbate in two-stage urinary bladder carcinogenesis in rats. Cancer Res, 47: 3492-3495, 1987.

25. Fukushima, S., Ito, N., El-Bolkainy, MN., Tawfik, HN., Tatemoto, Y., Mori, M.: Immunohistochemical observations of keratins, involucrin, and epithelial membrane antigen in urinary bladder carcinomas from patients infected with Schistosoma haematobium. Virchows Arch A, 411: 103-115, 1987.

26. Fukushima, S., Shibata, MA., Tamano, S., Ito, N., Suzuki, E., Okada, M.: Aging and urianary bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine. J Natl Cancer Inst, 79: 263-267, 1987.

27. Shibata, MA., Kurata, Y., Ogiso, T., Tamano, S., Fukushima, S., Ito, N.: Combined chronic toxicity and carcinogenicity studies of morpholine oleic acid salt in B6C3F1 mice. Fd Chem Toxicol, 25: 569-574, 1987.

28. Moore, MA., Tsuda, H., Hacker, HJ., Sato, K., Bannasch, P., Ito, N.: Altered enzyme expression in propylnitrosamine-induced Syrian hamster lung lesions. Virchows Arch B, 53: 272-278, 1987.

29. Kurata, Y., Tsuda, H., Sakata, T., Yamashita, T., Ito, N.: Reciprocal modifying effects of isomeric forms of aminophenol on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine. Carcinogenesis, 8: 1281-1285, 1987.

30. Hirose, M., Inoue, T., Masuda, A., Tsuda, H., Ito, N.: Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomach hyperplasia — complete inhibition by diethylmaletate in a 5-week feeding study. Carcinogenesis, 8: 1555-1558, 1987.

31. Tatematsu, M., Fukushima, S., Aoki, T., Mera, Y., Inoue, T., Ito, N.: Patterns of epithelial proliferation revealed by continuous administration of bromodeoxyuridine during urinary bladder carcinogenesis in rats. Jpn J Cancer Res (Gann), 78: 879-882, 1987.

32. Shirai, T., Ikawa, E., Imaida, K., Tagawa, Y., Ito, N.: Proliferative response of rat accessory sex organs to dietary sex hormones after castration or initial dietary administration of estrogen. J Urol, 138: 216-218, 1987.

33. Ito, N., Hirose, M.: The role of antioxidants in chemical carcinogenesis. Jpn J Cancer Res (Gann), 78: 1011-1026, 1987.

34. Shirai, T., Fukushima, S., Hirose, M., Ohshima, M., Ito, N.: Epithelial lesions of the urinary bladder in three hundred and thirteen autopsy cases. Jpn J Cancer Res (Gann), 78: 1073-1080, 1987.

35. Fukushima, S., Shibata, MA., Shirai, T., Kurata, Y., Tamano, S., Imaida, K.: Promotion by L-ascorbic acid of urinary bladder carcinogenesis in rats under conditions of increased urinary K ion concentratin and pH. Cancer Res, 47: 4821-4824, 1987.

36. Masui, T., Asamoto, M., Hirose, M., Fukushima, S., Ito, N.: Regression of simple hyperplasia and papillomas and persistence of basal cell hyperplasia in the forestomach of F344 rats treated with butylated hydroxyanisole. Cancer Res, 47: 5171-5174, 1987.

37. Shibata, MA., Kurata, Y., Tamano, S., Ogiso, T., Fukushima, S., Ito, N.: 13-week subchronic toxicity study with morpholine oleic acid salt administered to B6C3F1 mice. J Toxicol Environ Health, 22: 187-194, 1987.

38. Hirose, M., Masuda, A., Tsuda, H., Uwagawa, S., Ito, N.: Enhancement of BHA-induced proliferative rat forestomach lesion development by simultaneous treatment with other antioxidants. Carcinogenesis, 8: 1731-1735, 1987.

39. Fukushima, S., Shirai, T., Hirose, M.: The role L-ascorbic acid and urinary electolytes in promotion of rat blaader carcinogenesis. Exp Pathol, 31: 69-70, 1987.

40. Hirose, M., Kurata, Y., Tsuda, H., Fukushima, S., Ito, N.: Catechol strongly enhances rat stomach carcinogenesis: A possible new environmental stomach carcinogen. Jpn J Cancer Res (Gann), 78: 1144-1149, 1987.

41. Tsuda, H., Masui, T., Ikawa, E., Imaida, K., Ito, N.: Compared promoting potential of D-galactosamine, carbon tetrachloride and partial hepatectomy in rapid induction of preneoplastic liver lesions in the rat. Cancer Lett, 37: 163-171, 1987.

42. Okamura, T., Ohtani, M., Inoue, K., Fukushima, S., Ohtaguro, K., Kakizoe, T.: Effects of intravesical instillation of antitumor chemotherapeutic and immunotherapeutic agents on bladder lesion development in rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. J Urol, 138: 1305-1307, 1987.

43. Shirai, T., Tagawa, Y., Fukushima, S., Imaida, K., Ito, N.: Strong promoting activity of reversible uracil-induced urolithiasis on urinary bladder carcinogenesis in rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res, 47: 6726-6730, 1987.

44. Ito, N.: Organ-specific modifying effects of phenobarbital, saccharin and antioxidants on 2-stage chemical carcinogenesis. In: Chambers, PL., Gehring, P., Sakai, F. (eds.) New Concepts and Developments in Toxicology, pp359-369. Elsevier Science Publishers B.V. (Biomedical Division), 1987.

45. Tsuda, H., Aoki, T., Ito, N.: Effects of α-tocopherol on carcinogenesis in various organs of rats. In: Hayashi, O. & Mino, M. (eds.) Clinical and Nutritional Aspects of Vitamin E, pp329-332. Elservier Science Publish BV. (Biomedical Division), 1987.

46. Hiasa, Y., Ito, N.: Experimental induction of renal tumors. CRC Crit Rev Toxicol, 17: 279-343, 1987.

1. Hirose, M., Masuda, A., Kurata, Y., Ikawa, E., Mera, Y., Ito, N.: Histologic and autoradiographic studies on the forestomach of hamsters treated with 2-tert-butylated hydroxyanisole, 3-tert-butylated hydroxyanisole, crude butylated hydroxyanisole, or butylated hydroxytoluene. J Natl Cancer Inst, 76: 143-149, 1986.

2. Fukushima, S., Thamavit, W., Kurata, Y., Ito, N.: Sodium citrate: A promoter of bladder carcinogenesis. Jpn J Cancer Res (Gann), 77: 1-4, 1986.

3. Moore, MA., Thamavit, W., Tsuda, H., Sato, K., Ichihara, A., Ito, N.: Modifying influence of dehydroepiandrosterone on the development of dihydroxy-di-n-propylnitrosamine-initiated lesions in the thyroid, lung and liver of F344 rats. Carcinogenesis, 7: 311-316, 1986.

4. Moore, MA., Tsuda, H., Ito, N.: Dehydrogenase histochemistry of N-ethyl-N-hydroxyethylnitrosamine- induced focal liver lesions in the rat — increase in NADPH-generating capacity. Carcinogenesis, 7: 339-342, 1986.

5. Moore, MA., Nakamura, T., Shirai, T., Ichihara, A., Ito, N.: Immunohistochemical demonstration of increased glucose-6-phosphate dehydrogenase in preneoplastic and neoplastic lesions induced by propylnitrosamines in F344 rats and syrian hamsters. Jpn J Cancer Res (Gann), 77: 131-138, 1986.

6. Moore, MA., Thamavit, W., Tsuda, H., Ito, N.: The influence of subsequent dehydroepiandrosterone, diaminopropane, phenobarbital, butylated hydroxyanisole and butylated hydroxytoluene treatment on the development of preneoplastic and neoplastic lesions in the rat initiated with di-hydroxy-di-N-propyl nitrosamine. Cancer Lett, 30: 153-160, 1986.

7. Hirose, M., Hagiwara, A., Masui, T., Inoue, K., Ito, N.: Combined effects of butylated hydroxyanisole and other antioxidants in induction of forestomach lesions in rats. Cancer Lett, 30: 169-174, 1986.

8. Masui, T., Tsuda, H., Inoue, K., Ogiso, T., Ito, N.: Inhibitory effects of ethoxyquin, 4,4′-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis. Jpn J Cancer Res (Gann), 77: 231-237, 1986.

9. Tatematsu, M., Furihata, C., Mera, Y., Shirai, T., Matsushima, T., Ito, N.: Immunohistochemical demonstration of induction of pyloric glands with low pepsinogen 1 (Pg 1) content in rat stomach by N-methyl-N’-nitro-N-nitrosoguanidine. Jpn J Cancer Res (Gann), 77: 238-243, 1986.

10. Nishio, Y., Kakizoe, T., Ohtani, M., Sato, S., Sugimura, T., Fukushima, S.: L-isoleucine and L-leucine: Tumor promoters of bladder cancer in rats. Science, 231: 843-845, 1986.

11. Ikawa, E., Tsuda, H., Sakata, T., Masui, T., Satoh, K., Sato, K., Ito, N.: Modification potentials of ethyl alcohol and acetaldehyde on development of preneoplastic gultathione S-transferase p-form-positive liver cell foci initiated by diethylnitrosamine in the rat. Cancer Lett, 31: 53-60, 1986.

12. Fukushima, S., Shibata, MA., Shirai, T., Tamano, S., Ito, N.: Roles of urinary sodium ion concentration and pH in promotion by ascorbic acid of urinary bladder carcinogenesis in rats. Cancer Res, 46: 1623-1626, 1986.

13. Ohtani, M., Kakizoe, T., Nishio, Y., Sato, S., Sugimura, T., Fukushima, S., Niijima, T.: Sequential changes of mouse bladder epithelium during induction of invasive carcinomas by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res, 46: 2001-2004, 1986.

14. Shirai, T., Ikawa, E., Fukushima, S., Masui, T., Ito, N.: Uracil-induced urolithiasis and the development of reversible papillomatosis in the urinary bladder of F344 rats. Cancer Res, 46: 2062-2067, 1986.

15. Sato, A., Yonekura, I., Asakawa, M., Nakahara, H., Nakajima, T., Ohta, S., Shirai, T., Ito, N.: Augmentation of ethanol-induced enhancement of dimethylnitrosamine and diethylnitrosamine metabolism by lowered carbohydrate intake. Jpn J Cancer Res (Gann), 77: 125-130, 1986.

16. Moore, MA., Fukushima, S., Ichihara, A., Sato, K., Ito, N.: Intestinal metaplasia and altered enzyme expression in propylnitrosamine-induced syrian hamster cholangiocellular and gallbladder lesions. Virchows Arch [Cell Pathol], 51: 29-38, 1986.

17. Moore, MA., Thamavit, W., Ichihara, A., Sato, K., Ito, N.: Influence of dehydroepiandrosterone, diaminopropane and butylated hydroxyanisole treatment during the induction phase of rat liver nodular lesions in a short-term system. Carcinogenesis, 7: 1059-1063, 1986.

18. Hirose, M., Masuda, A., Inoue, T., Fukushima, S., Ito, N.: Modification by antioxidants and p,p’-diaminodiphenylmethane of 7,12-dimethylbenz[a]anthracene-induced carcinogenesis of the mammary gland and ear duct in CD rats. Carcinogenesis, 7: 1155-1159, 1986.

19. Hirose, M., Inoue, T., Asamoto, M., Tagawa, Y., Ito, N.: Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labeling indices of the glandular stomach and urinary bladder epithelium of
Syrian golden hamsters. Carcinogenesis, 7: 1285-1289, 1986.

20. Moore, MA., Nakamura, T., Thamavit, W., Ichihara, A., Ito, N.: Immunohistochemically demonstrated suppressed expression of tryptophan oxygenase, a marker for liver differentiation, within putative preneoplastic rat liver lesions. Carcinogenesis, 7: 1393-1396, 1986.

21. Hasegawa, R., Tsuda, H., Shirai, T., Kurata, Y., Masuda, A., Ito, N.: Effect of timing of partial hepatectomy on the induction of preneoplastic liver foci in rats given hepatocarcinogens. Cancer Lett, 32: 15-23, 1986.

22. Hirose, M., Thamavit, W., Asamoto, M., Osawa, T., Ito, N.: Inhibition of glutathione S-transferase P type-positive foci development by linolic acid hydroperoxides and their secondary oxidative products in a rat in vivo mid-term test for liver carcinogens. Toxicol Lett, 32: 51-58, 1986.

23. Tsuda, H., Hacker, HJ., Katayama, H., Masui, T., Ito, N., Bannasch, P.: Correlative histochemical studies on preneoplastic and neoplastic lesions in the kidney of rats treated with nitrosamines. Virchows Arch [Cell Pathol], 51: 385-404, 1986.

24. Tatematsu, M., Furihata, C., Katsuyama, T., Miki, K., Honda, H., Konishi, Y., Ito, N.: Gastric and intestinal phenotypic expressions of human signet ring cell carcinomas revealed by their biochemistry, mucin histochemistry, and ultrastructure. Cancer Res, 46: 4866-4872, 1986.

25. Moore, MA., Nakamura, T., Ito, N.: Immunohistochemically demonstrated glucose-6-phosphate dehydrogenase, γ-glutamyl transpeptidase, ornithine decarboxylase and glutathione S-transferase enzymes: absence of direct correlation with cell proliferation in rat liver putative preneoplastic lesions. Carcinogenesis, 7: 1419-1424, 1986.

26. Masui, T., Asamoto, M., Hirose, M., Fukushima, S., Ito, N.: Disappearance of upward proliferation and persistence of downward basal cell proliferation in rat forestomach papillomas induced by butylated hydroxyanisole. Jpn J Cancer Res (Gann), 77: 854-857, 1986.

27. Hasegawa, R., Fukushima, S., Furukawa, F., Takahashi, M., Ito, N.: Aberrant colonic epithelium in the bladder: Report of a case. J Urol, 136: 901-902, 1986.

28. Ito, N., Hirose, M., Fukushima, S., Tsuda, H., Tatematsu, M., Asamoto, M.: Modifying effects of antioxidants on chemical carcinogenesis. Toxicol Pathol, 14: 315-323, 1986.

29. Kurata, Y., Asamoto, M., Hagiwara, A., Masui, T., Fukushima, S.: Promoting effects of various agents in rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett, 32: 125-135, 1986.

30. Shibata, MA., Nakanishi, K., Shibata, M., Masui, T., Miyata, Y., Ito, N.: Promoting effect of sodium chloride in 2-stage urinary bladder carcinogenesis in rats initiated by N-butyl-N- (4-hydroxybutyl)nitrosamine. Urol Res, 14: 201-206, 1986.

31. Ohtani, M., Kakizoe, T., Sato, S., Sugimura, T., Fukushima, S.: Strain differences in mice with invasive bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. J Cancer Res Clin Oncol, 112: 107-110, 1986.

32. Fukushima, S., Shibata, MA., Kurata, Y., Tamano, S., Masui, T.: Changes in the urine and scanning electron microscopically observed appearance of the rat bladder following treatment with tumor promoters. Jpn J Cancer Res (Gann), 77: 1074-1082, 1986.

33. Masui, T., Hirose, M., Imaida, K., Fukushima, S., Tamano, S., Ito, N.: Sequential changes of the forestomach of F344 rats, Syrian golden hamsters, and B6C3F1 mice treated with butylated hydroxyanisole. Jpn J Cancer Res (Gann), 77: 1083-1090, 1986.

34. Nakamura, TA., Fukushima, S., Ito, N., Takai, Y., Tatemoto, Y., Mori, M.: Histochemical observation of lectin-binding patterns in Paget’s disease. Acta Histochem Cytochem, 19: 451-464, 1986.

35. Tatematsu, M., Mera, Y., Kohda, K., Kawazoe, Y., Ito, N.: Ornithine decarboxylase activity and DNA synthesis in rats after long term treatment with butylated hydroxyanisole, sodium saccharin or phenobarbital. Cancer Lett, 33: 119-124, 1986.

36. Shirai, T., Fukushima, S., Ikawa, E., Tagawa, Y., Ito, N.: Induction of prostate carcinoma in situ at high incidence in F344 rats by a combination of 3,2′-dimethyl-4-aminobiphenyl and ethinyl estradiol. Cancer Res, 46: 6423-6426, 1986.

37. Ito, N., Fukushima, S., Tamano, S., Hirose, M., Hagiwara, A.: Dose response in butylated hydroxyanisole induction of forestomach carcinogenesis in F344 rats. J Natl Cancer Inst, 77: 1261-1265, 1986.

38. Ito, N., Hirose, M., Fukushima, S., Tsuda, H., Shirai, T., Tatematsu, M.: Studies on antioxidants: their carcinogenic and modifying effects on chemical carcinogenesis. Fd Chem Toxicol, 24: 1071-1082, 1986.

39. Hayashi, M., Tsuda, H., Okumura, M., Hirose, M., Ito, N.: Histopathological classification of nephroblastomas in slaughtered swine. J Comp Pathol, 96: 35-46, 1986.

40. Fukushima, S., Shirai, T., Hirose, M., Ito, N.: Significance of L-ascorbic acid and urinary electrolytes in promotion of rat bladder carcinogenesis. In: Hayashi, Y. et al (eds.) Diet, Nutrition and Cancer, pp159-168. Tokyo: Japan Sci Soc Press, Tokyo/VNU Sci Press, Utrecht, 1986.

1. Moore, MA., Satoh, K., Kitahara, A., Sato, K., Ito, N.: A protein cross-reacting immunohistochemically with rat glutathione s-transferase placental form as a marker for preneoplasia in syrian hamster pancreatic and hepatocarcinogenesis. Jpn J Cancer Res (Gann), 76: 1-4, 1985.

2. Shirai, T., Imaida, K., Ohshima, M., Fukushima, S., Lee, MS., King, CM., Ito, N.: Different responses to phenobarbital promotion in the development of γ-glutamyltranspeptidase-positive foci in the liver of rats initiated with diethylnitrosamine, N-hydroxy-2-acetylaminofluorene and aflatoxin B1. Jpn J Cancer Res (Gann), 76: 16-19, 1985.

3. Shibata, MA., Hagiwara, A., Tamano, S., Fukushima, S., Ito, N.: Subchronic toxicity study of sodium o-phenylphenate in mice. Toxicol Lett, 25: 239-246, 1985.

4. Shirai, T., Takahashi, M., Fukushima, S., Ito, N.: Marked epithelial hyperplasia of the rat glandular stomach induced by long-term administration of iodoacetamide. Acta Pathol Jpn, 35: 35-43, 1985.

5. Furihata, C., Sato, Y., Matsushima, T., Tatematsu, M.: Induction of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by methylglyoxal. Carcinogenesis, 6: 91-94, 1985.

6. Shirai, T., Ikawa, E., Hirose, M., Thamavit, W., Ito, N.: Modification by five antioxidants of 1,2-dimethylhydrazine-initiated colon carcinogenesis in F344 rats. Carcinogenesis, 6: 637-639, 1985.

7. Thamavit, W., Tatematsu, M., Ogiso, T., Mera, Y., Tsuda, H., Ito, N.: Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase. Cancer Lett, 27: 295-303, 1985.

8. Kurata, Y., Tsuda, H., Tamano, S., Ito, N.: Inhibitory potential of acetaminophen and o-, m-, p-aminophenols for development of γ-glutamyltranspeptidase-positive liver cell foci in rats pretreated with diethylnitrosamine. Cancer Lett, 28: 19-25, 1985.

9. Shirai, T., Hosoda, K., Hirose, K., Hirose, M., Ito, N.: Promoting effects of phenobarbital and 3′-methyl-4-dimethylaminoazobenzene on the appearance of γ-glutamyltranspeptidase positive foci in rat liver pretreated with varying doses of diethylnitrosamine. Cancer Lett, 28: 127-133, 1985.

10. Fukushima, S., Kurata, Y., Ogiso, T., Okuda, M., Miyata, Y., Ito, N.: Pathological analysis of the carcinogenicity of sodium o-phenylphenate and o-phenylphenol. Oncology, 42: 304-311, 1985.

11. Shirai, T., Sakata, T., Fukushima, S., Ikawa, E., Ito, N.: Rat prostate as one of the target organs for 3,2′-dimethyl-4-aminobiphenyl-induced carcinogenesis: Effects of dietary ethinyl estradiol and methyltestosterone. Jpn J Cancer Res (Gann), 76: 803-808, 1985.

12. Ito, N., Fukushima, S., Tsuda, H.: Carcinogenicity and modification of the carcinogenic response by BHA, BHT and other antioxidants. CRC Crit Rev Toxicol, 15: 109-150, 1985.

13. Fukushima, S., Kurata, Y., Tamano, S., Inoue, K., Ito, N.: Promoting effect of trisodium nitrilotriacetate monohydrate on urinary bladder carcinogenesis in rats. Jpn J Cancer Res (Gann), 76: 823-827, 1985.

14. Miyata, Y., Fukushima, S., Hirose, M., Masui, T., Ito, N.: Short-term screening of promoters of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats. Jpn J Cancer Res (Gann), 76: 828-834, 1985.

15. Okamura, T., Fukushima, S., Inoue, K., Ito, N., Ueda, K., Ohtaguro, K.: Sequential studies of rat urinary bladder epithelial lesions induced by ifosfamide (Z4942). J Urol, 134: 778-781, 1985.

16. Tsuda, H., Moore, MA., Asamoto, M., Satoh, K., Tsuchida, S., Sato, K., Ichihara, A., Ito, N.: Comparison of the various forms of glutathione S-transferase with glucose-6-phosphate dehydrogenase and γ-glutamyltranspeptidase as markers of preneoplastic and neoplastic lesions in rat kidney induced by N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res (Gann), 76: 919-929, 1985.

17. Tatematsu, M., Mera, Y., Ito, N., Satoh, K., Sato, K.: Relative merits of immunohistochemical demonstrations of placental, A, B and C forms of glutathione S-transferase and histochemical demonstration of γ-glutamyl transferase as markers of altered foci during liver carcinogenesis in rats. Carcinogenesis, 6: 1621-1626, 1985.

18. Shirai, T., Masuda, A., Fukushima, S., Hosoda, K., Ito, N.: Effects of sodium L-ascorbate and related compounds on rat stomach carcinogenesis initiated by N-methyl-N’-nitro-N-nitrosoguanidine. Cancer Lett, 29: 283-288, 1985.

19. Kishikawa, H., Mizuno, T., Takagi, I., Yamakawa, Y., Shimozato, T., Honda, K., Tatematsu, M.: Nonfunctioning adrenocortical carcinoma in a young girl. Jpn J Surg, 15: 477-482, 1985.

20. Sumitomo, S., Tatemoto, Y., Fukui, S., Nakamura, T., Fukushima, S., Ito, N., Mori, M.: False positive reaction for carcinoembryonic antigen in paget cells. Virchows Arch [Cell Pathol], 49: 395-399, 1985.

21. Ogiso, T., Tatematsu, M., Tamano, S., Tsuda, H., Ito, N.: Comparative effects of carcinogens on the induction of placental glutathione S-transferase-positive liver nodules in a short-term assay and of hepatocellular carcinomas in a long-term assay. Toxicol Pathol, 13: 257-265, 1985.

22. Fukushima, S., Ito, N.: Papilloma, Forestomach, Rat. In: Jones, TC., Mohr, U., Hunt, RD. (eds.) Digestive System, pp289-292. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo, 1985.

23. Fukushima, S., Ito, N.: Squamous Cell Carcinoma, Forestomach, Rat. In: Jones, TC., Mohr, U., Hunt, RD. (eds.) Digestive System, pp292-295. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo, 1985.

24. Tatematsu, M., Ito, N.: Placental type of glutathione-S-transferase as a new marker for liver carcinogenesis. In: Jones, TC., Konishi, Y., Mohr, U. (eds.) The Liver, Salivary Glands, and Exocrine Pancreas of Laboratory Animals, Vol.28, pp145. Exp Pathol, 1985.

25. Moore, MA., Ito, N.: Comparative aspects of propyl nitrosamine carcinogenesis in Syrian golden hamsters. In: Jones, TC., Konishi, Y., Mohr, U. (eds.) The Liver, Salivary Glands, and Exocrine Pancreas of Laboratory Animals, Vol.28, pp145-146. Exp Pathol, 1985.