1. Tatematsu, M., Lurie, AG., Rippey, RM., Conran, PB., Arai, M., Fukushima, S., Ito, N.: Possible mechanistic roles of anatomical and functional vascular changes in rat urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res, 44: 278-284, 1984.

2. Ito, N., Moore, MA., Bannasch, P.: Modification of the development of N-nitrosomorpholine-induced hepatic lesions by 2-acetylaminofluorene, phenobarbital and 4,4′-diaminodiphenylmethane: a sequential histological and histochemical analysis. Carcinogenesis, 5: 335-342, 1984.

3. Furihata, C., Tatematsu, M., Miki, K., Katsuyama, T., Sudo, K., Miyagi, N., Kubota, T., Jin, SS., Kodama, K., Ito, N., Konishi, Y., Suzuki, K., Matsushima, T.: Gastric- and intestinal-type properties of human gastric cancers transplanted into nude mice. Cancer Res, 44: 727-733, 1984.

4. Shirai, T., Arai, M., Sakata, T., Fukushima, S., Ito, N.: Primary carcinomas of urinary bladder diverticula. Acta Pathol Jpn, 34: 417-424, 1984.

5. Tsuda, H., Nakanishi, K., Hatano, A., Okumura, M., Seki, K.: Summational effect of three different hepatopromoters in rats after initiation with diethylnitrosamine. Nagoya Med J, 28: 171-182, 1984.

6. Shirai, T., Ohshima, M., Masuda, A., Tamano, S., Ito, N.: Promotion of 2-(ethylnitrosamino)- ethanol-induced renal carcinogenesis in rats by nephrotoxic compounds: Positive responses with folic acid, basic lead acetate, and N-(3,5-dichlorophenyl)succinimide but not with 2,3-dibromo-1-propanol phosphate. J Natl Cancer Inst, 72: 477-482, 1984.

7. Tsuda, H., Sakata, T., Masui, T., Imaida, K., Ito, N.: Modifying effects of butylated hydroxyanisole, ethoxyquin and acetaminophen on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine. Carcinogenesis, 5: 525-531, 1984.

8. Sato, K., Kitahara, A., Satoh, K., Ishikawa, T., Tatematsu, M., Ito, N.: The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis. Gann, 75: 199-202, 1984.

9. Yanagi, S., Tsuda, H., Sakamoto, M., Fuse, E., Ito, N.: Effects of margarine on hepatocarcinogenesis by N,N’-2,7-fluorenylenebisacetamide in mice. Oncology, 41: 101-105, 1984.

10. Sato, K., Kitahara, A., Yin, Z., Waragai, F., Nishimura, K., Hatayama, I., Ebina, T., Yamazaki, T., Tsuda, H., Ito, N.: Induction by butylated hydroxyanisole of specific molecular forms of glutathione S-transferase and UDP-glucuronyltransferase and inhibition of development of γ-glutamyl transpeptidase-positive foci in rat liver. Carcinogenesis, 5: 473-477, 1984.

11. Shirai, T., Fukushima, S., Ohshima, M., Masuda, A., Ito, N.: Effects of butylated hydroxyanisole, butylated hydroxytoluene, and NaCl on gastric carcinogenesis initiated with N-methyl-N’-nitro-N-nitrosoguanidine in F344 rats. J Natl Cancer Inst, 72: 1189-1198, 1984.

12. Ito, N., Hirose, M., Kurata, Y., Ikawa, E., Mera, Y., Fukushima, S.: Induction of forestomach hyperplasia by crude butylated hydroxyanisole, a mixture of 3-tert and 2-tert isomers, in syrian golden hamsters is due to 3-tert-butylated hydroxyanisole. Gann, 75: 471-474, 1984.

13. Shirai, T., Kurata, Y., Fukushima, S., Ito, N.: Dose-related induction of lung, thyroid and kidney tumors by N-bis(2-hydroxypropyl)nitrosamine given orally to F344 rats. Gann, 75: 502-507, 1984.

14. Fukushima, S., Kurata, Y., Shibata, MA., Ikawa, E., Ito, N.: Promotion by ascorbic acid, sodium erythorbate and ethoxyquin of neoplastic lesions in rats initiated with N-butyl-N-(4-hydroxybutyl) nitrosamine. Cancer Lett, 23: 29-37, 1984.

15. Kitahara, A., Satoh, K., Nishimura, K., Ishikawa, T., Ruike, K., Sato, K., Tsuda, H., Ito, N.: Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis. Cancer Res, 44: 2698-2703, 1984.

16. Miyata, Y., Fukushima, S., Imaida, K., Ito, N.: Promoting effects of unilateral ureteric ligation on two-stage urinary bladder carcinogenesis in rats. Cancer Lett, 23: 265-272, 1984.

17. Tsuda, H., Sakata, T., Shirai, T., Kurata, Y., Tamano, S., Ito, N.: Modification of N-methyl-N-nitrosourea initiated carcinogenesis in the rat by subsequent treatment with antioxidants, phenobarbital and ethinyl estradiol. Cancer Lett, 24: 19-27, 1984.

18. Ito, N., Shirai, T., Fukushima, S., Hirose, M.: Dose-response study of urinary bladder carcinogenesis in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine. J Cancer Res Clin Oncol, 108: 169-173, 1984.

19. Sato, A., Nakajima, T., Koyama, Y., Shirai, T., Ito, N.: Dietary carbohydrate level as a modifying factor of 3′-methyl-4-dimethylaminoazobenzene liver carcinogenesis in rats. Gann, 75: 665-671, 1984.

20. Tsuda, H., Fukushima, S., Imaida, K., Sakata, T., Ito, N.: Modification of carcinogenesis by antioxidants and other compounds. Acta Pharmacol Toxicol, 55: 125-143, 1984.

21. Tsuda, H., Tamano, S., Imaida, K., Ohshima, M., Kitahori, Y., Ito, N.: Three-dimensional observations by scanning electron microscopy on the blood supply and organization of vasculature during hepatocarcinogenesis in rats. Acta Pathol Jpn, 34: 957-970, 1984.

22. Hagiwara, A., Fukushima, S., Kitaori, M., Shibata, M., Ito, N.: Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 75: 763-768, 1984.

23. Imaida, K., Fukushima, S., Shirai, T., Masui, T., Ogiso, T., Ito, N.: Promoting activities of butylated hydroxyanisole, butylated hydroxytoluene and sodium L-ascorbate on forestomach and urinary bladder carcinogenesis initiated with methylnitrosourea in F344 male rats. Gann, 75: 769-775, 1984.

24. Hagiwara, A., Shibata, M., Hirose, M., Fukushima, S., Ito, N.: Long-term toxicity and carcinogenicity study of sodium o-phenylphenate in B6C3F1 mice. Fd Chem Toxicol, 22: 809-814, 1984.

25. Tsuda, H., Takano, T., Shirai, T., Suzuki, M., Baba, S., Ito, N.: Comparative light and scanning electron microscopic observations of nasal cavity carcinogenesis in rats treated with 1,4-dinitrosopiperazine. J Cancer Res Clin Oncol, 108: 186-191, 1984.

26. Fukushima, S., Tsuda, H., Shirai, T., Nakakita, T., Sawaguchi, K., Takahashi, M.: An autopsy case of holoprosencephaly with cyclopia. Nagoya Med J, 29: 1-5, 1984.

27. Ito, N., Ogiso, T., Fukushima, S., Shibata, M., Hagiwara, A.: Carcinogenicity of captafol in B6C3F1 mice. Gann, 75: 853-865, 1984.

28. Tsuda, H., Masui, T., Imaida, K., Fukushima, S., Ito, N.: Promotive effect of primary and secondary bile acids on the induction of γ-glutamyl transpeptidase-positive liver cell foci as a possible endogenous factor for hepatocarcinogenesis in rats. Gann, 75: 871-875, 1984.

29. Tsuda, H., Hasegawa, R., Imaida, K., Masui, T., Moore, MA., Ito, N.: Modifying potential of thirty-one chemicals on the short-term development of γ-glutamyl transpeptidase-positive foci in diethylnitrosamine-initiated rat liver. Gann, 75: 876-883, 1984.

30. Shirai, T., Masuda, A., Hirose, M., Ikawa, E., Ito, N.: Enhancement of N-bis(2- hydroxypropyl)nitrosamine-initiated lung tumor development in rats by bleomycin and N-methyl-N-nitrosourethane. Cancer Lett, 25: 25-31, 1984.

31. Ohtani, M., Fukushima, S., Okamura, T., Sakata, T., Ito, N., Koiso, K., Niijima, T.: Effects of intravesical instillation of antitumor chemotherapeutic agents on bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer, 54: 1525-1529, 1984.

32. Moore, MA., Tsuda, H., Ogiso, T., Mera, Y., Ito, N.: Enhancement of phenotypic instability by α-difluoromethylornithine and butylated hydroxyanisole in rapidly induced rat liver lesions. Cancer Lett, 25: 145-151, 1984.

33. Sakata, T., Shirai, T., Fukushima, S., Hasegawa, R., Ito, N.: Summation and synergism in the promotion of urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine in F344 rats. Gann, 75: 950-956, 1984.

34. Tatematsu, M., Katsuyama, T., Furihata, C., Tsuda, H., Ito, N.: Stable intestinal phenotypic expression of gastric and small intestinal tumor cells induced by N-methyl- N’-nitro-N-nitrosoguanidine or methylnitrosourea in rats. Gann, 75: 957-965, 1984.

35. Yanagi, S., Tsuda, H., Sakamoto, M., Ninomiya, Y., Ito, N.: Evaluation of a histologic classification of mouse liver tumors based on pyruvate kinase isozymes and status of host lipids. J Natl Cancer Inst, 73: 1311-1317, 1984.

36. Fukushima, S., Hagiwara, A., Ogiso, T., Shibata, MA., Kurata, Y., Ito, N.: Spontaneous tumors in F344/DuCrj rats. Nagoya Med J, 29: 163-172, 1984.

37. Ito, N., Fukushima, S., Tsuda, H., Shirai, T., Tatematsu, M., Imaida, K.: Modification of chemical carcinogenesis by antioxidants. In: Fujiki, H. et al (eds.) Cellular Interactions by Environmental Tumor Promoters, pp381-389. Japan Sci Soc Press,Tokyo/VNU Science Press, Utrecht, 1984.

38. Ito, N., Fukushima, S., Shirai, T., Hagiwara, A., Imaida, K.: Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis. In: Borzsonyi, K. et al (eds.) Models, Mechanisms and Etiology of Tumour Promotion, IARC Scientific Publications No.56, pp399-407. International Agency for Research on Cancer, Lyon, 1984.

1. Fukushima, S., Hagiwara, A., Ogiso, T., Shibata, M., Ito, N.: Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-n-butyl-(4-hydroxybutyl)amine. Fd Chem Toxicol, 21: 59-68, 1983.

2. Hotta, K., Yamamoto, Y., Imaida, K., Oshima, M., Fukushima, S., Ito, N.: Membrance potential of rat urinary bladder epithelial cells. Jpn J Physiol, 33: 139-143, 1983.

3. Ito, N., Fukushima, S., Shirai, T., Nakanishi, K., Hasegawa, R., Imaida, K.: Modifying factors in urinary bladder carcinogenesis. Environ Health Perspect, 49: 217-222, 1983.

4. Fukushima, S., Arai, M., Nakanowatari, J., Hibino, T., Okuda, M., Ito, N.: Differences in susceptibility to sodium saccharin among various strains of rats and other animal species. Gann, 74: 8-20, 1983.

5. Shirai, T., Nakanowatari, J., Kurata, Y., Fukushima, S., Ito, N.: Different dose-response relationships in the induction of different types of colonic tumors in Wistar rats by 1,2-dimethylhydrazine. Gann, 74: 21-27, 1983.

6. Takahashi, M., Kokubo, T., Furukawa, F., Kurokawa, Y., Tatematsu, M., Hayashi, Y.: Effect of high salt diet on rat gastric carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine. Gann, 74: 28-34, 1983.

7. Ito, N., Fukushima, S., Hagiwara, A., Shibata, M., Ogiso, T.: Carcinogenicity of butylated hydroxyanisole in F344 rats. J Natl Cancer Inst, 70: 343-352, 1983.

8. Tatematsu, M., Furihata, C., Katsuyama, T., Hasegawa, R., Nakanowatari, J., Saito, D., Takahashi, M., Matsushima, T., Ito, N.: Independent induction of intestinal metaplasia and gastric cancer in rats treated with N-methyl-N’-nitro-N-nitrosoguanidine. Cancer Res, 43: 1335-1341, 1983.

9. Tatematsu, M., Hasegawa, R., Imaida, K., Tsuda, H., Ito, N.: Survey of various chemicals for initiating and promoting activities in a short-term in vivo system based on generation of hyperplastic liver nodules in rats. Carcinogenesis, 4: 381-386, 1983.

10. Imaida, K., Ishihara, Y., Nishio, O., Nakanishi, K., Ito, N.: Carcinogenicity and toxicity tests on p-phenylenediamine in F344 rats. Toxicol Lett, 16: 259-269, 1983.

11. Tsuda, H., Sakata, T., Tamano, S., Okumura, M., Ito, N.: Sequential observations on the appearance of neoplastic lesions in the liver and kidney after treatment with N- ethyl-N-hydroxyethylnitrosamine followed by partial hepatectomy and unilateral nephrectomy. Carcinogenesis, 4: 523-528, 1983.

12. Imaida, K., Oshima, M., Fukushima, S., Ito, N., Hotta, K.: Membrane potentials of urinary bladder epithelium in F344 rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine or sodium saccharin. Carcinogenesis, 4: 659-661, 1983.

13. Ito, N., Fukushima, S., Shirai, T., Nakanishi, K.: Effects of promoters on N-butyl-N- (4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. Environ Health Perspect, 50: 61-69, 1983.

14. Ito, N., Tsuda, H., Hasegawa, R., Imaida, K.: Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver. Environ Health Perspect, 50: 131-138, 1983.

15. Imaida, K., Fukushima, S., Shirai, T., Ohtani, M., Nakanishi, K., Ito, N.: Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of γ-glutamyl transpeptidase-positive foci development in the liver of rats. Carcinogenesis, 4: 895-899, 1983.

16. Tsuda, H., Fukushima, S., Imaida, K., Kurata, Y., Ito, N.: Organ-specific promoting effect of phenobarbital and saccharin in induction of thyroid, liver, and urinary bladder tumors in rats after initiation with N-nitrosomethylurea. Cancer Res, 43: 3292-3296, 1983.

17. Ito, N., Fukushima, S., Imaida, K., Sakata, T., Masui, T.: Induction of papilloma in the forestomach of hamsters by butylated hydroxyanisole. Gann, 74: 459-461, 1983.

18. Ito, N., Tsuda, H., Sakata, T., Hasegawa, R., Tamano, S.: Inhibitory effect of butylated hydroxyanisole and ethoxyquin on the induction of neoplastic lesions in rat liver after an initial treatment with N-ethyl-N-hydroxyethylnitrosamine. Gann, 74: 466-468, 1983.

19. Tsuda, H., Miyata, Y., Hatano, A., Inui, M., Ito, N.: Effects of dietary lithocholic and deoxycholic acids on rat liver. Nagoya Med J, 28: 65-70, 1983.

20. Fukushima, S., Imaida, K., Sakata, T., Okamura, T., Shibata, MA., Ito, N.: Promoting effects of sodium L-ascorbate on two-stage urinary bladder carcinogenesis in rats. Cancer Res., 43: 4454-4457, 1983.

21. Hayashi, M., Tsuda, H., Ito, N.: Histopathological classification of spontaneous hyperplastic liver nodules in slaughtered swine. J Comp Pathol, 93: 603-612, 1983.

22. Tamano, S., Tsuda, H., Fukushima, S., Masui, T., Hosoda, K., Ito, N.: Dose and sex dependent effects of 2-acetylaminofluorene, 3′-methyl-4-dimethylaminoazobenzene and DL-ethionine in induction of γ-glutamyl transpeptidase-positive liver cell foci in rats. Cancer Lett, 20: 313-321, 1983.

23. Fukushima, S., Kurata, Y., Shibata, MA., Ikawa, E., Ito, N.: Promoting effect of sodium o-phenylphenate and o-phenylphenol on two-stage urinary bladder carcinogenesis in rats. Gann, 74: 625-632, 1983.

24. Hirose, M., Fukushima, S., Sakata, T., Inui, M., Ito, N.: Effect of quercetin on two-stage carcinogenesis of the rat urinary bladder. Cancer Lett, 21: 23-27, 1983.

25. Lurie, AG., Tatematsu, M., Nakatsuka, T., Rippey, RM., Ito, N.: Anatomical and functional vascular changes in hamster cheek pouch during carcinogenesis induced by 7,12-dimethylbenz(a)anthracene. Cancer Res, 43: 5986-5994, 1983.

26. Hagiwara, A., Shibata, M., Kurata, Y., Seki, K., Fukushima, S., Ito, N.: Long-term toxicity and carcinogenicity test of ammonia-process caramel colouring given to B6C3F1 mice in the drinking-water. Fd Chem Toxicol, 21: 701-706, 1983.

27. Ohtani, M., Fukushima, S., Ito, N., Koiso, K., Niijima, T.: Effects of intravesical instillation of antitumor drugs on the induction of preneoplastic bladder lesions in rats. Cancer Chemother Pharmacol, 11 (Suppl): S64-S66, 1983.

28. Tsuda, H.: Goiter, adenoma, and carcinoma of the thyroid induced by amitrole and ethylenethiourea, rat. In: Jones, TC., Moher, U., Hunt, RD.(eds.) Endocrine System, pp204-211. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo, 1983.

29. Sato, K., Kitahara, A., Yin, Z., Ebina, T., Satoh, K., Tsuda, H., Ito, N., Dempo, K.: Molecular forms of glutathione S-transferase and UDP-glucuronyltransferase as hepatic preneoplastic marker enzymes. In: Alpert, E., Hirai, H. (eds.) Annals of the New York Academy of Sciences, Vol.417, pp213-223. ANN N.Y. Acad Sci, New York, 1983.

1. Tatematsu, M., Katsuyama, T., Nakanowatari, J., Hasegawa, R., Imaida, K., Fukushima, S., Ito, N.: Region-specific patterns of mucin reaction demonstrated by paradoxical concanavalin A-staining in normal colonic epithelium and in colorectal cancers induced in rats by 1,2-dimethylhydrazine. Gann, 73: 77-84, 1982.

2. Hasegawa, R., Tsuda, H., Ogiso, T., Ohshima, M., Ito, N.: Initiating activities of pyrolysis products of L-lysine and soybean globulin assessed in terms of the induction of γ-glutamyl transpeptidase-positive foci in rat liver. Gann, 73: 158-159, 1982.

3. Fukushima, S., Murasaki, G., Hirose, M., Nakanishi, K., Hasegawa, R., Ito, N.: Histopathological analysis of preneoplastic changes during N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder carcinogenesis in rats. Acta Pathol Jpn, 32: 243-250, 1982.

4. Nakanishi, K., Kurata, Y., Ohshima, M., Fukushima, S., Ito, N.: Carcinogenicity of phenacetin: long-term feeding study in B6C3F1 mice. Int J Cancer, 29: 439-444, 1982.

5. Nakanishi, K., Fukushima, S., Hagiwara, A., Tamano, S., Ito, N.: Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats. J Natl Cancer Inst, 68: 497-500, 1982.

6. Yin, Z., Sato, K., Tsuda, H., Ito, N.: Changes in activities of uridine diphosphate- glucuronyltransferases during chemical hepatocarcinogenesis. Gann, 73: 239-248, 1982.

7. Hasegawa, R., Tatematsu, M., Tsuda, H., Shirai, T., Hagiwara, A., Ito, N.: Induction of hyperplastic liver nodules in hepatectomized rats treated with 3′-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide. Gann, 73: 264-269, 1982.

8. Ito, N., Hagiwara, A., Shibata, M., Ogiso, T., Fukushima, S.: Induction of squamous cell carcinoma in the forestomach of F344 rats treated with butylated hydroxyanisole. Gann, 73: 332-334, 1982.

9. Hasegawa, R., Tatematsu, M., Imaida, K., Murasaki, G., Ito, N., Watanabe, I., Nakazato, M.: Neuroblastoma in situ. Acta Pathol Jpn, 32: 537-546, 1982.

10. Hirose, M., Takahashi, M., Fukushima, S., Shibata, M., Ito, N.: Chronic effects of 1,3-di(4-sulfamoylphenyl)triazene on male ICR mice. Nagoya Med J, 26: 173-177, 1982.

11. Cameron, RG., Imaida, K., Tsuda, H., Ito, N.: Promotive effects of steroids and bile acids on hepatocarcinogenesis initiated by diethylnitrosamine. Cancer Res, 42: 2426-2428, 1982.

12. Imaida, K., Hirose, M., Ogisa, T., Kurata, Y., Ito, N.: Quantitative analysis of initiating and promoting activities of five mycotoxins in liver carcinogenesis in rats. Cancer Lett, 16: 137-143, 1982.

13. Fukushima, S., Hirose, M., Okuda, M., Nakanowatari, J., Hatano, A., Ito, N.: Effect of partial cystectomy on the induction of pre-neoplastic lesions in rat bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by bladder carcinogens and promoters. Urol Res, 10: 115-118, 1982.

14. Takano, T., Shirai, T., Ogiso, T., Tsuda, H., Baba, S., Ito, N.: Sequential changes in tumor development induced by 1,4-dinitrosopiperazine in the nasal cavity of F344 rats. Cancer Res, 42: 4236-4240, 1982.

15. Hasegawa, R., Tsuda, H., Nakanishi, K., Tatematsu, M., Ito, N.: Route-dependent, organ-specific effects of carcinogens on induction of hyperplastic liver nodules in rats. Toxicol Lett, 14: 229-235, 1982.

16. Shirai, T., Hagiwara, A., Kurata, Y., Shibata, M., Fukushima, S., Ito, N.: Lack of carcinogenicity of butylated hydroxytoluene on long-term administraiton to B6C3F1 mice. Fd Chem Toxicol, 20: 861-865, 1982.

17. Ogiso, T., Arai, Y., Fukushima, S., Nishizuka, Y., Ito, N.: Enhancing effect of diethylstilbestrol on urinary bladder carcinogenesis in neonatally castrated male rats. Gann, 73: 862-869, 1982.

18. Shirai, T., Imaida, K., Fukushima, S., Hasegawa, R., Tatematsu, M., Ito, N.: Effects of NaCl, Tween 60 and a low dose of N-ethyl-N’-nitro-N-nitrosoguanidine on gastric carcinogenesis of rat given a single dose of N-methyl-N’-nitro-N-nitrosoguanidine. Carcinogenesis, 3: 1419-1422, 1982.

19. Tsuda, H., Hagiwara, A., Shibata, M., Ohshima, M., Ito, N.：Carcinogenic effect of carbazole in the liver of (C57BL/6N x C3H/HeN)F1 mice. J Natl Cancer Inst, 69: 1383-1389, 1982.

20. Yanagi, S., Sakamoto, M., Tsuda, H., Tatematsu, M., Ito, N., Yamamoto, N., Furuyama, S.: Effect of safflower oil and safflower margarine on hepatic tumorigenesis by N,N’-2,7-fluorenylenebisacetamide. J Nara Med Assoc, 33: 545-548, 1982.

21. Hasegawa, R., Imaida, K., Fukushima, S., Tsuda, H., Ito, N., Masuko, K.: Effect of hemodialysis on amyloid deposition (18 Autopsy Cases). Nagoya Med J, 27: 277-286, 1982.

22. Ito, N., Tsuda, H., Hasegawa, R., Imaida, K.: Sequential observation of pathomorphologic alterations in preneoplastic lesions during the promoting stage of hepatocarcinogenesis and the development of short-term test system for hepatopromoters and hepatocarcinogens. Toxicol Pathol, 10: 37-49, 1982.

23. Ito, N., Tatematsu, M., Nakanishi, K., Tsuda, H.: Analysis of the effect of promoting agents on liver and urinary bladder carcinogenesis in rats. In: Hecker, E., Fusenig, NE., Kunz, W., Marks, F., Thielmann, HW.(eds.) Carcinogenesis. A Comprehensive Survey, Vol.7, pp133-137. Raven Press, New York, 1982.

24. Ito, N., Fukushima, S., Tsuda, H., Shirai, T., Arai, M.: Induction of preneoplastic and neoplastic lesions in rats treated N-nitroso compounds. In: Bartsch, H., O’Neill, IK., Castegnaro, M., Okada, M. (eds.) N-nitroso-compounds: Occurrence and Biological Effects, IARC Scientific Publication Vol.41, pp597-601. International Agency for Research on Cancer, Lyon, 1982.

25. Ito, N., Nakanishi, K., Fukushima, S., Tsuda, H., Shirai, T.: Promoting and inhibiting factors on liver and urinary bladder carcinogenesis in rats. In: Pani, P., Feo, F., Columbano, A. (eds.) Recent Trends in Chemical Carcinogenesis, Vol.1, pp199-213. ESA, Cagliari, 1982.

1. Cameron, R., Imaida, K., Ito, N.: Promotive effects of ethinyl estradiol in hepatocarcinogenesis initiated by diethylnitrosamine in male rats. Gann, 72: 339-340, 1981.

2. Hirose, M., Shibata, M., Hagiwara, A., Imaida, K., Ito, N.: Chronic toxicity of butylated hydroxytoluene in Wistar rats. Fd Cosmet Toxicol, 19: 147-151, 1981.

3. Tatematsu, M., Imaida, K., Ito, N., Togari, H., Suzuki, Y., Ogiu, T.: Sandhoff disease. Acta Pathol Jpn, 31: 503-512, 1981.

4. Tatematsu, M., Imaida, K., Fukushima, S., Arai, M., Mizutani, M., Ito, N.: Cytopathological effect of partial cystectomy of rats. Acta Pathol Jpn, 31: 535-543, 1981.

5. Ito, N., Hirose, M., Shirai, T., Tsuda, H., Nakanishi, K., Fukushima, S.: Lesions of the urinary bladder epithelium in 125 autopsy cases. Acta Pathol Jpn, 31: 545-557, 1981.

6. Cameron, R., Imaida, K., Ito, N.: Promotive effects of deoxycholic acid on hepatocarcinogenesis initiated by diethylnitrosamine in male rats. Gann, 72: 635-636, 1981.

7. Takahashi, M., Shirai, T., Fukushima, S., Ito, N., Kokubo, T., Furukawa, F., Kurata, Y.: Ulcer formation and associated tumor production in multiple sites within the stomach and duodenum of rats treated with N-methyl-N’-nitro-N-nitrosoguanidine. J Natl Cancer Inst, 67: 473-479, 1981.

8. Hirose, M., Imaida, K., Ito, H., Hayashi, M., Ishihara, Y., Ito, N.: Effects of chloroform and dimethylnitrosamine on renal carcinogenesis in unilaterally nephrectomized rats fed formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide. Carcinogenesis, 2: 703-708, 1981.

9. Tamano, S., Tsuda, H., Tatematsu, M., Hasegawa, R., Imaida, K., Ito, N.: Induction of γ-glutamyl transpeptidase positive foci in rat liver by pyrolysis products of amino acids. Gann, 72: 747-753, 1981.

10. Fukushima, S., Ishihara, Y., Nishio, O., Ogiso, T., Shirai, T., Ito, N.: Carcinogenicities of quinoline derivatives in F344 rats. Cancer Lett, 14: 115-123, 1981.

11. Suganuma, T., Katsuyama, T., Tsukahara, M., Tatematsu, M., Sakakura, Y., Murata, F.: Comparative histochemical study of alimentary tracts with special reference to the mucous neck cells of the stomach. Am J Anatomy, 161: 219-238, 1981.

12. Fukushima, S., Hirose, M., Hagiwara, A., Hasegawa, R., Ito, N.: Inhibitory effect of 4,4’-diaminodiphenylmethane on liver, kidney and bladder carcinogenesis in rats ingesting N-ethyl-N-hydroxyethylnitrosamine or N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 2: 1033-1037, 1981.

13. Sato, K., Hatayama, I., Hoshino, K., Imai, F., Tsuchida, S., Sato, T., Nishimura, K., Tatematsu, M., Ito, N.: Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens. Cancer Res, 41: 4147-4153, 1981.

14. Imaida, K., Shirai, T., Tatematsu, M., Takano, T., Ito, N.: Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis. Cancer Lett, 14: 279-283, 1981.

15. Hirose, M., Shirai, T., Tsuda, H., Fukushima, S., Ogiso, T., Ito, N.: Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally. Carcinogenesis, 2: 1299-1302, 1981.

16. Ito, N.: In vivo carcinogenesis of 4-nitroquinoline 1-oxide and related compounds. In: Sugimura, T. (ed.) Carcinogenesis, Vol. 6, pp117-153. Raven Press, New York, 1981.

1. Tada, M., Takahashi, K., Kawazoe, Y., Ito, N.: Binding of quinoline to nucleic acid in a subcellular microsomal system. Chem Biol Interact, 29: 257-266, 1980.

2. Miyata, Y., Hagiwara, A., Nakatsuka, T., Murasaki, G., Arai, M., Ito, N.: Effects of caffeine and saccharin on DNA in the bladder epithelium of rats treated with N-butyl-N-(3-carboxypropyl)nitrosamine. Chem Biol Interact, 29: 291-302, 1980.

3. Hayashi, M., Ishihara, Y., Nishio, O., Tatematsu, M., Makino, M., Asai, T.: Histopathological observations of spontaneous tumors in slaughtered-animals (73 cases). Nagoya Med J, 24: 163-176, 1980.

4. Arai, M., Ito, H., Nakanishi, K., Hasegawa, R., Yoshimura, T., Murasaki, G., Ito, N.: Ultrastructural study of changes of the basement membrane and capillaries of the urinary bladder in rats induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Nagoya Med J, 24: 177-187, 1980.

5. Tatematsu, M., Saito, D., Furihata, C., Miyata, Y., Nakatsuka, T., Ito, N., Sugimura, T.: Initial DNA damage and heritable permanent change in pepsinogen isoenzyme pattern in the pyloric mucosae of rats after short-term administration of N-methyl-N’-nitro-N-nitrosoguanidine. J Natl Cancer Inst, 64: 775-781, 1980.

6. Tatematsu, M., Katsuyama, T., Fukushima, S., Takahashi, M., Shirai, T., Ito, N., Nasu, T.: Mucin histochemistry by paradoxical concanavalin A staining in experimental gastric cancers induced in Wistar rats by N-methyl-N’-nitro-N-nitrosoguanidine or 4-nitroquinoline 1-oxide. J Natl Cancer Inst, 64: 835-843, 1980.

7. Murasaki, G., Miyata, Y., Babaya, K., Arai, M., Fukushima, S., Ito, N.: Inhibitory effect of an aromatic retinoic acid analog on urinary bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 71: 333-340, 1980.

8. Miyata, Y., Nakatsuka, T., Arai, M., Murasaki, G., Nakanishi, K., Ito, N.: Inhibition by an aromatic retinoid of DNA damage induced by the bladder carcinogen N-butyl-N-(3-carboxypropyl)nitrosamine. Gann, 71: 341-348, 1980.

9. Ito, N., Tatematsu, M., Imaida, K., Hasegawa, R., Murasaki, G.: Effects of various promoters on the induction of hyperplastic nodules in rat liver. Gann, 71: 415-416, 1980.

10. Hagiwara, A., Arai, M., Hirose, M., Nakanowatari, J., Tsuda, H., Ito, N.: Chronic effects of norharman in rats treated with aniline. Toxicol Lett, 6: 71-75, 1980.

11. Cohen, SM., Tatematsu, M., Shinohara, Y., Nakanishi, K., Ito, N.: Neovascularization in rats during urinary bladder carcinogenesis induced by N-[4-(5-nitro-2-furyl)thiazolyl]formamide. J Natl Cancer Inst, 65: 145-148, 1980.

12. Nakanishi, K., Hirose, M., Ogiso, T., Hasegawa, R., Arai, M., Ito, N.: Effect of sodium saccharin and caffeine on the urinary bladder of rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 71: 490-500, 1980.

13. Takano, T., Tatematsu, M., Hasegawa, R., Imaida, K., Ito, N.: Dose-response relationship for the promoting effect of phenobarbital on the induction of liver hyperplastic nodules in rats exposed to 2-fluorenylacetamide and carbon tetrachloride. Gann, 71: 580-581, 1980.

14. Hirose, M., Murasaki, G., Imaida, K., Fukushima, S., Ito, N.: Effect of cyclophosphamide on rat urinary bladder epithelium treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 71: 729-732, 1980.

15. Hirose, M., Fukushima, S., Shibata, M., Ito, N.: Chronic effects of oral ethylenecyanohydrin on male rats and mice. Nagoya Med J, 25: 1-5, 1980.

16. Nakanishi, K., Hagiwara, A., Shibata, M., Imaida, K., Tatematsu, M., Ito, N.: Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. J Natl Cancer Inst, 65: 1005-1010, 1980.

17. Takahashi, M., Arai, M., Kokubo, T., Furukawa, F., Kurata, Y., Ito, N.: An ultrastructural study of precancerous and cancerous lesions of the pancreas in Syrian golden hamsters induced by N-nitrosobis(2-oxopropyl)amine. Gann, 71: 825-831, 1980.

18. Ito, N., Tatematsu, M., Nakanishi, K., Hasegawa, R., Takano, T., Imaida, K., Ogiso, T.: The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide. Gann, 71: 832-842, 1980.

19. Tatematsu, M., Takano, T., Hasegawa, R., Imaida, K., Nakanowatari, J., Ito, N.: A sequential quantitative study of the reversibility or irreversibility of liver hyperplastic nodules in rats exposed to hepatocarcinogens. Gann, 71: 843-855, 1980.

20. Ito, N., Nakanishi, K., Hagiwara, A., Shibata, M., Fukushima, S.: Induction of hyperplasic liver nodules by phenobarbital in rats initiated with N-butyl-N-(4- hydroxybutyl)nitrosamine. Gann, 71: 918-919, 1980.

1. Tatematsu, M., Murasaki, G., Nakanishi, K., Miyata, Y., Shinohara, Y., Ito, N.: Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals. Gann, 70: 125-130, 1979.

2. Murasaki, G., Miyata, Y., Shirai, T., Arai, M., Kawachi, T., Ito, N.: Effects of the co-mutagen norharman in rats. Toxicol Lett, 3: 157-161, 1979.

3. Fukushima, S., Shibata, M., Hibino, T., Yoshimura, T., Hirose, M., Ito, N.: Intrahepatic bile duct proliferation induced by 4,4’-diaminodiphenylmethane in rats. Toxicol Appl Pharmacol, 48: 145-155, 1979.

4. Shinohara, Y., Hasegawa, R., Ito, N., Kanayama, M., Kato, T., Wada, Y.: Tyrosinemia. Acta Pathol Jpn, 29: 615-622, 1979.

5. Arai, M., Aoki, Y., Nakanishi, K., Miyata, Y., Mori, T., Ito, N.: Long-term experiment of maximal non-carcinogenic dose of dimethylnitrosamine for carcinogenesis in rats. Gann, 70: 549-558, 1979.

6. Hirose, M., Maekawa, A., Kamiya, S., Odashima, S.: Carcinogenic effect of N-ethyl- and N-amyl-N-nitrosourethans on female Donryu rats. Gann, 70: 653-662, 1979.

7. Lurie, AG., Rippey, RM., Conran, PB., Tatematsu, M., Ito, N.: A technique for multiparametric analysis of hemodynamic changes in rat urinary bladder during carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 70: 717-718, 1979.

8. Tatematsu, M., Nakatsuka, T., Lurie, AG., Rippey, RM., Suzuki, M., Ito, N.: Neovascularization during hamster cheek pouch carcinogenesis induced by 7,12-dimethylbenz[a]anthracene. Gann, 70: 719-720, 1979.

9. Tsuchida, S., Hoshino, K., Sato, T., Ito, N., Sato, K.: Purification of γ-glutamyltranferases from rat hepatomas and hyperplastic hepatic nodules, and comparison with the enzyme from rat kidney. Cancer Res, 39: 4200-4205, 1979.

10. Tatematsu, M., Nakanishi, K., Murasaki, G., Miyata, Y., Hirose, M., Ito, N.: Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats. J Natl Cancer Inst, 63: 1411-1416, 1979.

11. Ito, N., Takahashi, M., Fukushima, S., Shirai, T., Tatematsu, M.: Factors which modify induction of experimental glandular gastric cancer in rats and mice. In: Pfeiffer, CJ.(ed.) Experimental Gastric Cancer. Etiology and Pathogenesis, pp277-301. Gerhard Witzstrock Publising House, Inc., New York, 1979.

12. Imai, F., Takaya, S., Hatayama, I., Sato, T., Ito, N., Sato, K.: Rat hyperplastic hepatic nodules and primary hepatomas retaining abnormally high pyruvate kinase L type activity. In: Colombo, JP., Frei, J., Greengard, O., Knox, WE. (eds.) Enzyme, Vol.24, pp313-321. S. Karger, Basel, 1979.

1. Tatematsu, M., Takahashi, M., Tsuda, H., Ogiso, T., Ito, N.: The administration of reserpine to rats for 75 weeks. Toxicol Lett, 1: 201-205, 1978.

2. Ito, N., Tatematsu, M., Hirose, M., Nakanishi, K., Murasaki, G.: Enhancing effect of chemicals on production of hyperplastic liver nodules induced by N-2-fluorenylacetamide in hepatectomized rats. Gann, 69: 143-144, 1978.

3. Shirai, T., Cohen, SM., Fukushima, S., Hananouchi, M., Ito, N.: Reversible papillary hyperplasia of the rat urinary bladder. Am J Pathol, 91: 33-48, 1978.

4. Hiasa, Y., Ito, N., Ohshima, M., Ohmori, T., Seki, A., Tatsumi, T., Yokoi, H., Iwata, C., Murata, Y., Ito, N.: Ultrastructure of an anaplastic giant-cell carcinoma found 8 years after operation of a papillary carcinoma of the thyroid. Acta Pathol Jpn, 28: 637-644, 1978.

5. Takahashi, M., Shirai, T., Fukushima, S., Hosoda, K., Yoshida, S., Ito, N.: Carcinogenicity of 8-nitroquinoline in Sprague-Dawley rats. Cancer Lett, 4: 265-270, 1978.

6. Shirai, T., Miyata, Y., Nakanishi, K., Murasaki, G., Ito, N.: Hepatocarcinogenicity of polychlorinated terphenyl (PCT) in ICR mice and its enhancement by hexachlorobenzene (HCB). Cancer Lett, 4: 271-275, 1978.

7. Shirai, T., Takahashi, M., Fukushima, S., Tatematsu, M., Hirose, M., Ito, N.: Induction of preneoplastic hyperplasia and carcinoma by N-methyl-N’-nitrosoguanidine from regenerated mucosa of ulcers induced by iodoacetamide in fundus of rat stomach. Gann, 69: 361-366, 1978.

8. Nakanishi, K., Fukushima, S., Shibata, M., Shirai, T., Ogiso, T., Ito, N.: Effect of phenacetin and caffeine on the urinary bladder of rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 69: 395-400, 1978.

9. Tatematsu, M., Cohen, SM., Fukushima, S., Shirai, T., Shinohara, Y., Ito, N.: Neovascularization in benign and malignant urinary bladder epithelial proliferative lesions of the rat observed in situ by scanning electron microscopy and autoradiography. Cancer Res, 38: 1792-1800, 1978.

10. Takahashi, K., Kawazoe, Y., Tada, M., Tada, M., Ito, N., Okada, M.: Carcinogenicity of 4-nitrosoquinoline 1-oxide and its possible role in carcinogenesis by 4-nitroquinoline 1-oxide. Gann, 69: 499-505, 1978.

11. Arai, H., Shirai, T., Hananouchi, M., Hirose, M., Murasaki, G., Ito, N.: Effect of protease inhibitors in mice treated with the hepatocarcinogen, hexachlorocyclohexane (α-isomer) and the bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 69: 593-595, 1978.

12. Sato, K., Takaya, S., Imai, F., Hatayama, I., Ito, N.: Different deviation patterns of carbohydrate-metabolizing enzymes in primary rat hepatomas induced by different chemical carcinogens. Cancer Res, 38: 3086-3093, 1978.

13. Murasaki, G., Nakanishi, K., Ito, N., Arai, M., Masuko, K.: Electron microscopic observation of the liver in Dubin-Johnson syndrome. J Clin Electron Microscopy, 11: 5-6, 1978.

14. Tsuda, H., Takahashi, M., Murasaki, G., Ogiso, T., Tatematsu, M.: Effect of 3-amino-1H-1,2,4-triazole or low iodine diet on rat thyroid carcinogenesis induced by ethylenethiourea. Nagoya Med J, 23: 83-92, 1978.

15. Cohen, SM., Fukushima, S., Tsuda, H., Murasaki, G., Ito, N.: Effect of azathiopurine and OK-432 on urinary bladder carcinogenesis in rats. Gann, 69: 773-779, 1978.

16. Kawazoe, Y., Ogawa, O., Takahashi, K., Sawanishi, H., Ito, N.: Synthesis of 4-(N-hydroxy-N-methylamino)quinoline 1-oxide and its carcinogenic activity on mice. Gann, 69: 835-837, 1978.

17. Miyata, Y., Tsuda, H., Matayoshi-Miyasato, K., Fukushima, S., Murasaki, G., Ogiso, T., Ito, N.: Effect of vitamin A acetate on urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats. Gann, 69: 845-848, 1978.

18. Ito, N., Shirai, T., Miyata, Y.: Production of urinary bladder tumors by administration of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) to pregnant, nursing and newborn rats. In: Severi, L.(ed.) Tumours of Early Life in Man and Animals, pp495-503. Perugia, Monteluce, Italy: Perugia Quadrennial International Conferences on Cancer, Perugia, Italy, 1978.

1. Tatematsu, M., Cohen, SM., Fukushima, S., Shinohara, Y., Ito, N.: Vascular changes during rat urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 68: 127-128, 1977.

2. Nagao, M., Yahagi, T., Seino, Y., Sugimura, T., Ito, N.: Mutagenicities of quinoline and its derivatives. Mutation Res, 42: 335-342, 1977.

3. Tsuda, H., Miyata, Y., Murasaki, G., Kinoshita, H., Fukushima, S., Ito, N.: Synergistic effect of urinary bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine, N-[4-(5-nitro-2-furyl)-2-thiazolyl]- formamide, N-2-fluorenylacetamide, and 3,3′-dichlorobenzidine. Gann, 68: 183-192, 1977.

4. Tatematsu, M., Miyata, Y., Mizutani, M., Hananouchi, M., Hirose, M., Ito, N.: Summation effect of N-butyl-N-(4-hydroxybutyl)nitrosamine, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide, N-2-fluorenyl- acetamide, and 3,3′-dichlorobenzidine on urinary bladder carcinogenesis in rats. Gann, 68: 193-202, 1977.

5. Shirai, T., Murasaki, G., Tatematsu, M., Tsuda, H., Fukushima, S., Ito, N.: Early surface changes of the urinary bladder epithelium of different animal species induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 68: 203-212, 1977.

6. Tatematsu, M., Furihata, C., Hirose, M., Shirai, T., Ito, N., Nakajima, Y., Sugimura, T.: Changes in pepsinogen isozymes in stomach cancers induced in Wistar rats by N-methyl-N’-nitro-N-nitrosoguanidine and in transplantable gastric carcinoma (SG2B). J Natl Cancer Inst, 58: 1709-1716, 1977.

7. Fukushima, S., Hibino, T., Shibata, M., Murasaki, G., Ogiso, T., Ito, N.: Effect of hepatotoxic or nephrotoxic agents on the induction of colon cancers in rats by 1,2-dimethylhydrazine. Toxicol Appl Pharmacol, 40: 561-570, 1977.

8. Shinohara, Y., Miyata, Y., Murasaki, G., Nakanishi, K., Yoshimura, T., Ito, N.: Effect of N-(3,5-dichlorophenyl)succinimide on the histological pattern and incidence of kidney tumors induced by streptozotocin in rats. Gann, 68: 397-404, 1977.

9. Tatematsu, M., Shirai, T., Tsuda, H., Miyata, Y., Shinohara, Y., Ito, N.: Rapid production of hyperplastic liver nodules in rats treated with carcinogenic chemicals: A new approach for an in vivo short-term screening test for hepatocarcinogens. Gann, 68: 499-507, 1977.

10. Cohen, SM., Ichikawa, M., Bryan, GT.: Carcinogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl)- acrylamide (AF-2) fed to female Sprague-Dawley rats. Gann, 68: 473-476, 1977.

11. Shirai, T., Cohen, SM., Fukushima, S., Ito, N.: Production of reversible papillary proliferation of the urinary bladder in rats. Gann, 68: 521-522, 1977.

12. Matsukura, N., Kawachi, T., Sasajima, K., Sano, T., Sugimura, T., Ito, N.: Induction of liver tumors in rats by sodium nitrite and methylguanidine. Z Krebsforsch, 90: 87-94, 1977.

13. Tsuda, H., Miyata, Y., Hagiwara, A., Hasegawa, R., Shirai, T., Ito, N.: Damage and repair of DNA in urinary bladder epithelium of rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 68: 781-783, 1977.

14. Shinohara, Y., Ogiso, T., Hananouchi, M., Nakanishi, K., Yoshimura, T., Ito, N.: Effect of various factors on the induction of liver tumors in animals by quinoline. Gann, 68: 785-796, 1977.

15. Fukushima, S., Hibino, T., Shibata, M., Tsuda, H., Shirai, T., Takahashi, M., Ito, N.: Effect of iodoacetamide or Tween 60 on methyl-nitrosocyanamide carcinogenesis in rat glandular and forestomach. Gann, 68: 813-818, 1977.

16. Tatematsu, M., Ito, N.: Neovascularization in benign and malignant rat urinary bladder epithelial proliferative lesions observed by scanning electron microscopy of vascular casts. J Clin Electron Microscopy, 10: 5-6, 1977.

17. Furihata, C., Tatematsu, M., Shirai, T., Yokochi, K., Takahashi, M., Sugimura, T.: Pepsinogens and stomach cancer. In: Farber, E. et al. (eds.) Pathophysiology of Carcinogenesis in Digestive Organs, pp49-63: Univ of Tokyo Press, Tokyo, 1977.

1. Takahashi, M., Shirai, T., Fukushima, S., Hananouchi, M., Hirose, M., Ito, N.: Effect of fundic ulcers induced by iodoacetamide on development of gastric tumors in rats treated with N-methyl-N’-nitrosoguanidine. Gann, 67: 47-54, 1976.

2. Fukushima, S., Hirose, M., Tsuda, H., Shirai, T., Hirao, K., Arai, M., Ito, N.: Histological classification of urinary bladder cancers in rats induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 67: 81-90, 1976.

3. Hirao, K., Shinohara, Y., Tsuda, H., Fukushima, S., Takahashi, M., Ito, N.: Carcinogenic activity of quinoline on rat liver. Cancer Res, 36: 329-335, 1976.

4. Tsuda, H., Fukushima, S., Takahashi, M., Hikosaka, Y., Hayashi, K.: Familial bilateral papillary cystadenoma of the epididymis. Cancer, 37: 1831-1839, 1976.

5. Shinohara, Y., Arai, M., Hirao, K., Sugihara, S., Nakanishi, K., Tsunoda, H., Ito, N.: Combination effect of citrinin and other chemicals on rat kidney tumorigenesis. Gann, 67: 147-155, 1976.

6. Hirose, M., Fukushima, S., Hananouchi, M., Shirai, T., Ogiso, T., Takahashi, M., Ito, N.: Different susceptibilities of the urinary bladder epithelium of animal species to three nitroso compounds. Gann, 67: 175-189, 1976.

7. Fukushima, S., Hananouchi, M., Shirai, T., Tatematsu, M., Hirose, M., Yoshida, S., Takahashi, M.: Effect of plastic bead on gastric carcinogenesis in rats treated with N-methyl-N’-nitro-N-nitrosoguanidine. Gann, 67: 197-205, 1976.

8. Tatematsu, M., Takahashi, M., Hananouchi, M., Shirai, T., Hirose, M., Fukushima, S., Ito, N.: Protective effect of mucin on experimental gastric cancer induced by N-methyl-N’-nitro-N-nitrosoguanidine plus sodium chloride in rats. Gann, 67: 223-229, 1976.

9. Hirose, M., Takahashi, M., Hananouchi, M., Tatematsu, M., Kinoshita, H., Fukushima, S., Ito, N.: Transplantation of chemically induced gastric cancer in Wistar rats. Gann, 67: 365-369, 1976.

10. Ito, N., Hananouchi, M., Sugihara, S., Shirai, T., Tsuda, H., Fukushima, S., Nagasaki, H.: Reversibility and irreversibility of liver tumors in mice induced by the α isomer of 1,2,3,4,5,6-hexachlorocyclohexane. Cancer Res, 36: 2227-2234, 1976.

11. Ito, N.: Early changes caused by N-butyl-N-(4-hydroxybutyl)nitrosamine in the bladder epithelium of different animal species. Cancer Res, 36: 2528-2531, 1976.

12. Miyamoto, J., Hosokawa, S., Kadota, T., Kohda, H., Arai, M., Sugihara, S., Hirao, K.: Studies on cholinesterase inhibition and structural changes at neuromuscular junctions in rabbits by subacute administration of sumithion. J Pesticide Sci, 1: 171-178, 1976.

13. Tsuda, H., Hananouchi, M., Tatematsu, M., Hirose, M., Hirao, K., Takahashi, M., Ito, N.: Tumorigenic effect of 3-amino-1H-1,2,4-triazole on rat thyroid. J Natl Cancer Inst, 57: 861-864, 1976.

14. Shirai, T., Furihata, C., Tatematsu, M., Fukushima, S., Ito, N., Sugimura, T.: Biochemical study of pyloric metaplasia in the mucosa regenerating over iodoacetamide-induced fundic ulcers in rat stomach. Gann, 67: 813-817, 1976.

1. Ito, N., Nagasaki, H., Aoe, H., Sugihara, S., Miyata, Y., Arai, M., Shirai, T.: Development of hepatocellular carcinomas in rats treated with benzene hexachloride. J Natl Cancer Inst, 54: 801-805, 1975.

2. Sugihara, S., Shinohara, Y., Miyata, Y., Inoue, K., Ito, N.: Pathologic analysis of chemical nephritis in rats induced by N-(3,5-dichlorophenyl)succinimide. Lab Invest, 33: 219-230, 1975.

3. Nagasaki, H., Kawabata, H., Miyata, Y., Inoue, K., Hirao, K., Aoe, H., Ito, N.: Effect of various factors on induction of liver tumors in animals by the α-isomer of benzene hexachloride. Gann, 66: 185-191, 1975.

4. Shirai, T., Takahashi, M., Fukushima, S., Tatematsu, M., Hananouchi, M., Ito, N.: Sequential morphological changes of ulceration in the glandular stomach of rats induced by iodoacetamide. Acta Pathol Jpn, 25: 463-476, 1975.

5. Tatematsu, M., Takahashi, M., Fukushima, S., Hananouchi, M., Shirai, T.: Effects in rats of sodium chloride on experimental gastric cancers induced by N-methyl-N’-nitro-N-nitrosoguanidine or 4-nitroquinoline-1-oxide. J Natl Cancer Inst., 55: 101-106, 1975.

6. Takahashi, M., Fukushima, S., Hananouchi, M.: Induction of undifferentiated adenocarcinoma in the stomach of rats by N-methyl-N’-nitro-N-nitrosoguanidine with various kinds of surfactant. Gann Monogr Cancer Res, 17: 255-267, 1975.

7. Ito, N., Arai, M., Sugihara, S., Hirao, K., Makiura, S., Matayoshi, K., Denda, A.: Experimental urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann Monogr Cancer Res, 17: 367-381, 1975.

8. Furihata, C., Sasajima, K., Kazama, S., Kogure, K., Kawachi, T., Sugimura, T., Tatematsu, M., Takahashi, M.: Changes in pepsinogen isozymes in stomach carcinogenesis induced in rats by N-methyl-N’-nitro-N-nitrosoguanidine. J Natl Cancer Inst, 55: 925-930, 1975.

9. Tatematsu, M., Takahashi, M., Tsuda, H., Hirose, M., Furihata, C., Sugimura, T.: Precocious differentiation of immature chief cells in fundic mucosa of infant rats induced by hydrocortisone. Cell Differentiation, 4: 285-294, 1975.