1. Hirose, M., Masuda, A., Kurata, Y., Ikawa, E., Mera, Y., Ito, N.: Histologic and autoradiographic studies on the forestomach of hamsters treated with 2-tert-butylated hydroxyanisole, 3-tert-butylated hydroxyanisole, crude butylated hydroxyanisole, or butylated hydroxytoluene. J Natl Cancer Inst, 76: 143-149, 1986.

2. Fukushima, S., Thamavit, W., Kurata, Y., Ito, N.: Sodium citrate: A promoter of bladder carcinogenesis. Jpn J Cancer Res (Gann), 77: 1-4, 1986.

3. Moore, MA., Thamavit, W., Tsuda, H., Sato, K., Ichihara, A., Ito, N.: Modifying influence of dehydroepiandrosterone on the development of dihydroxy-di-n-propylnitrosamine-initiated lesions in the thyroid, lung and liver of F344 rats. Carcinogenesis, 7: 311-316, 1986.

4. Moore, MA., Tsuda, H., Ito, N.: Dehydrogenase histochemistry of N-ethyl-N-hydroxyethylnitrosamine- induced focal liver lesions in the rat — increase in NADPH-generating capacity. Carcinogenesis, 7: 339-342, 1986.

5. Moore, MA., Nakamura, T., Shirai, T., Ichihara, A., Ito, N.: Immunohistochemical demonstration of increased glucose-6-phosphate dehydrogenase in preneoplastic and neoplastic lesions induced by propylnitrosamines in F344 rats and syrian hamsters. Jpn J Cancer Res (Gann), 77: 131-138, 1986.

6. Moore, MA., Thamavit, W., Tsuda, H., Ito, N.: The influence of subsequent dehydroepiandrosterone, diaminopropane, phenobarbital, butylated hydroxyanisole and butylated hydroxytoluene treatment on the development of preneoplastic and neoplastic lesions in the rat initiated with di-hydroxy-di-N-propyl nitrosamine. Cancer Lett, 30: 153-160, 1986.

7. Hirose, M., Hagiwara, A., Masui, T., Inoue, K., Ito, N.: Combined effects of butylated hydroxyanisole and other antioxidants in induction of forestomach lesions in rats. Cancer Lett, 30: 169-174, 1986.

8. Masui, T., Tsuda, H., Inoue, K., Ogiso, T., Ito, N.: Inhibitory effects of ethoxyquin, 4,4′-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis. Jpn J Cancer Res (Gann), 77: 231-237, 1986.

9. Tatematsu, M., Furihata, C., Mera, Y., Shirai, T., Matsushima, T., Ito, N.: Immunohistochemical demonstration of induction of pyloric glands with low pepsinogen 1 (Pg 1) content in rat stomach by N-methyl-N’-nitro-N-nitrosoguanidine. Jpn J Cancer Res (Gann), 77: 238-243, 1986.

10. Nishio, Y., Kakizoe, T., Ohtani, M., Sato, S., Sugimura, T., Fukushima, S.: L-isoleucine and L-leucine: Tumor promoters of bladder cancer in rats. Science, 231: 843-845, 1986.

11. Ikawa, E., Tsuda, H., Sakata, T., Masui, T., Satoh, K., Sato, K., Ito, N.: Modification potentials of ethyl alcohol and acetaldehyde on development of preneoplastic gultathione S-transferase p-form-positive liver cell foci initiated by diethylnitrosamine in the rat. Cancer Lett, 31: 53-60, 1986.

12. Fukushima, S., Shibata, MA., Shirai, T., Tamano, S., Ito, N.: Roles of urinary sodium ion concentration and pH in promotion by ascorbic acid of urinary bladder carcinogenesis in rats. Cancer Res, 46: 1623-1626, 1986.

13. Ohtani, M., Kakizoe, T., Nishio, Y., Sato, S., Sugimura, T., Fukushima, S., Niijima, T.: Sequential changes of mouse bladder epithelium during induction of invasive carcinomas by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res, 46: 2001-2004, 1986.

14. Shirai, T., Ikawa, E., Fukushima, S., Masui, T., Ito, N.: Uracil-induced urolithiasis and the development of reversible papillomatosis in the urinary bladder of F344 rats. Cancer Res, 46: 2062-2067, 1986.

15. Sato, A., Yonekura, I., Asakawa, M., Nakahara, H., Nakajima, T., Ohta, S., Shirai, T., Ito, N.: Augmentation of ethanol-induced enhancement of dimethylnitrosamine and diethylnitrosamine metabolism by lowered carbohydrate intake. Jpn J Cancer Res (Gann), 77: 125-130, 1986.

16. Moore, MA., Fukushima, S., Ichihara, A., Sato, K., Ito, N.: Intestinal metaplasia and altered enzyme expression in propylnitrosamine-induced syrian hamster cholangiocellular and gallbladder lesions. Virchows Arch [Cell Pathol], 51: 29-38, 1986.

17. Moore, MA., Thamavit, W., Ichihara, A., Sato, K., Ito, N.: Influence of dehydroepiandrosterone, diaminopropane and butylated hydroxyanisole treatment during the induction phase of rat liver nodular lesions in a short-term system. Carcinogenesis, 7: 1059-1063, 1986.

18. Hirose, M., Masuda, A., Inoue, T., Fukushima, S., Ito, N.: Modification by antioxidants and p,p’-diaminodiphenylmethane of 7,12-dimethylbenz[a]anthracene-induced carcinogenesis of the mammary gland and ear duct in CD rats. Carcinogenesis, 7: 1155-1159, 1986.

19. Hirose, M., Inoue, T., Asamoto, M., Tagawa, Y., Ito, N.: Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labeling indices of the glandular stomach and urinary bladder epithelium of
Syrian golden hamsters. Carcinogenesis, 7: 1285-1289, 1986.

20. Moore, MA., Nakamura, T., Thamavit, W., Ichihara, A., Ito, N.: Immunohistochemically demonstrated suppressed expression of tryptophan oxygenase, a marker for liver differentiation, within putative preneoplastic rat liver lesions. Carcinogenesis, 7: 1393-1396, 1986.

21. Hasegawa, R., Tsuda, H., Shirai, T., Kurata, Y., Masuda, A., Ito, N.: Effect of timing of partial hepatectomy on the induction of preneoplastic liver foci in rats given hepatocarcinogens. Cancer Lett, 32: 15-23, 1986.

22. Hirose, M., Thamavit, W., Asamoto, M., Osawa, T., Ito, N.: Inhibition of glutathione S-transferase P type-positive foci development by linolic acid hydroperoxides and their secondary oxidative products in a rat in vivo mid-term test for liver carcinogens. Toxicol Lett, 32: 51-58, 1986.

23. Tsuda, H., Hacker, HJ., Katayama, H., Masui, T., Ito, N., Bannasch, P.: Correlative histochemical studies on preneoplastic and neoplastic lesions in the kidney of rats treated with nitrosamines. Virchows Arch [Cell Pathol], 51: 385-404, 1986.

24. Tatematsu, M., Furihata, C., Katsuyama, T., Miki, K., Honda, H., Konishi, Y., Ito, N.: Gastric and intestinal phenotypic expressions of human signet ring cell carcinomas revealed by their biochemistry, mucin histochemistry, and ultrastructure. Cancer Res, 46: 4866-4872, 1986.

25. Moore, MA., Nakamura, T., Ito, N.: Immunohistochemically demonstrated glucose-6-phosphate dehydrogenase, γ-glutamyl transpeptidase, ornithine decarboxylase and glutathione S-transferase enzymes: absence of direct correlation with cell proliferation in rat liver putative preneoplastic lesions. Carcinogenesis, 7: 1419-1424, 1986.

26. Masui, T., Asamoto, M., Hirose, M., Fukushima, S., Ito, N.: Disappearance of upward proliferation and persistence of downward basal cell proliferation in rat forestomach papillomas induced by butylated hydroxyanisole. Jpn J Cancer Res (Gann), 77: 854-857, 1986.

27. Hasegawa, R., Fukushima, S., Furukawa, F., Takahashi, M., Ito, N.: Aberrant colonic epithelium in the bladder: Report of a case. J Urol, 136: 901-902, 1986.

28. Ito, N., Hirose, M., Fukushima, S., Tsuda, H., Tatematsu, M., Asamoto, M.: Modifying effects of antioxidants on chemical carcinogenesis. Toxicol Pathol, 14: 315-323, 1986.

29. Kurata, Y., Asamoto, M., Hagiwara, A., Masui, T., Fukushima, S.: Promoting effects of various agents in rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett, 32: 125-135, 1986.

30. Shibata, MA., Nakanishi, K., Shibata, M., Masui, T., Miyata, Y., Ito, N.: Promoting effect of sodium chloride in 2-stage urinary bladder carcinogenesis in rats initiated by N-butyl-N- (4-hydroxybutyl)nitrosamine. Urol Res, 14: 201-206, 1986.

31. Ohtani, M., Kakizoe, T., Sato, S., Sugimura, T., Fukushima, S.: Strain differences in mice with invasive bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. J Cancer Res Clin Oncol, 112: 107-110, 1986.

32. Fukushima, S., Shibata, MA., Kurata, Y., Tamano, S., Masui, T.: Changes in the urine and scanning electron microscopically observed appearance of the rat bladder following treatment with tumor promoters. Jpn J Cancer Res (Gann), 77: 1074-1082, 1986.

33. Masui, T., Hirose, M., Imaida, K., Fukushima, S., Tamano, S., Ito, N.: Sequential changes of the forestomach of F344 rats, Syrian golden hamsters, and B6C3F1 mice treated with butylated hydroxyanisole. Jpn J Cancer Res (Gann), 77: 1083-1090, 1986.

34. Nakamura, TA., Fukushima, S., Ito, N., Takai, Y., Tatemoto, Y., Mori, M.: Histochemical observation of lectin-binding patterns in Paget’s disease. Acta Histochem Cytochem, 19: 451-464, 1986.

35. Tatematsu, M., Mera, Y., Kohda, K., Kawazoe, Y., Ito, N.: Ornithine decarboxylase activity and DNA synthesis in rats after long term treatment with butylated hydroxyanisole, sodium saccharin or phenobarbital. Cancer Lett, 33: 119-124, 1986.

36. Shirai, T., Fukushima, S., Ikawa, E., Tagawa, Y., Ito, N.: Induction of prostate carcinoma in situ at high incidence in F344 rats by a combination of 3,2′-dimethyl-4-aminobiphenyl and ethinyl estradiol. Cancer Res, 46: 6423-6426, 1986.

37. Ito, N., Fukushima, S., Tamano, S., Hirose, M., Hagiwara, A.: Dose response in butylated hydroxyanisole induction of forestomach carcinogenesis in F344 rats. J Natl Cancer Inst, 77: 1261-1265, 1986.

38. Ito, N., Hirose, M., Fukushima, S., Tsuda, H., Shirai, T., Tatematsu, M.: Studies on antioxidants: their carcinogenic and modifying effects on chemical carcinogenesis. Fd Chem Toxicol, 24: 1071-1082, 1986.

39. Hayashi, M., Tsuda, H., Okumura, M., Hirose, M., Ito, N.: Histopathological classification of nephroblastomas in slaughtered swine. J Comp Pathol, 96: 35-46, 1986.

40. Fukushima, S., Shirai, T., Hirose, M., Ito, N.: Significance of L-ascorbic acid and urinary electrolytes in promotion of rat bladder carcinogenesis. In: Hayashi, Y. et al (eds.) Diet, Nutrition and Cancer, pp159-168. Tokyo: Japan Sci Soc Press, Tokyo/VNU Sci Press, Utrecht, 1986.

1. Moore, MA., Satoh, K., Kitahara, A., Sato, K., Ito, N.: A protein cross-reacting immunohistochemically with rat glutathione s-transferase placental form as a marker for preneoplasia in syrian hamster pancreatic and hepatocarcinogenesis. Jpn J Cancer Res (Gann), 76: 1-4, 1985.

2. Shirai, T., Imaida, K., Ohshima, M., Fukushima, S., Lee, MS., King, CM., Ito, N.: Different responses to phenobarbital promotion in the development of γ-glutamyltranspeptidase-positive foci in the liver of rats initiated with diethylnitrosamine, N-hydroxy-2-acetylaminofluorene and aflatoxin B1. Jpn J Cancer Res (Gann), 76: 16-19, 1985.

3. Shibata, MA., Hagiwara, A., Tamano, S., Fukushima, S., Ito, N.: Subchronic toxicity study of sodium o-phenylphenate in mice. Toxicol Lett, 25: 239-246, 1985.

4. Shirai, T., Takahashi, M., Fukushima, S., Ito, N.: Marked epithelial hyperplasia of the rat glandular stomach induced by long-term administration of iodoacetamide. Acta Pathol Jpn, 35: 35-43, 1985.

5. Furihata, C., Sato, Y., Matsushima, T., Tatematsu, M.: Induction of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by methylglyoxal. Carcinogenesis, 6: 91-94, 1985.

6. Shirai, T., Ikawa, E., Hirose, M., Thamavit, W., Ito, N.: Modification by five antioxidants of 1,2-dimethylhydrazine-initiated colon carcinogenesis in F344 rats. Carcinogenesis, 6: 637-639, 1985.

7. Thamavit, W., Tatematsu, M., Ogiso, T., Mera, Y., Tsuda, H., Ito, N.: Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase. Cancer Lett, 27: 295-303, 1985.

8. Kurata, Y., Tsuda, H., Tamano, S., Ito, N.: Inhibitory potential of acetaminophen and o-, m-, p-aminophenols for development of γ-glutamyltranspeptidase-positive liver cell foci in rats pretreated with diethylnitrosamine. Cancer Lett, 28: 19-25, 1985.

9. Shirai, T., Hosoda, K., Hirose, K., Hirose, M., Ito, N.: Promoting effects of phenobarbital and 3′-methyl-4-dimethylaminoazobenzene on the appearance of γ-glutamyltranspeptidase positive foci in rat liver pretreated with varying doses of diethylnitrosamine. Cancer Lett, 28: 127-133, 1985.

10. Fukushima, S., Kurata, Y., Ogiso, T., Okuda, M., Miyata, Y., Ito, N.: Pathological analysis of the carcinogenicity of sodium o-phenylphenate and o-phenylphenol. Oncology, 42: 304-311, 1985.

11. Shirai, T., Sakata, T., Fukushima, S., Ikawa, E., Ito, N.: Rat prostate as one of the target organs for 3,2′-dimethyl-4-aminobiphenyl-induced carcinogenesis: Effects of dietary ethinyl estradiol and methyltestosterone. Jpn J Cancer Res (Gann), 76: 803-808, 1985.

12. Ito, N., Fukushima, S., Tsuda, H.: Carcinogenicity and modification of the carcinogenic response by BHA, BHT and other antioxidants. CRC Crit Rev Toxicol, 15: 109-150, 1985.

13. Fukushima, S., Kurata, Y., Tamano, S., Inoue, K., Ito, N.: Promoting effect of trisodium nitrilotriacetate monohydrate on urinary bladder carcinogenesis in rats. Jpn J Cancer Res (Gann), 76: 823-827, 1985.

14. Miyata, Y., Fukushima, S., Hirose, M., Masui, T., Ito, N.: Short-term screening of promoters of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats. Jpn J Cancer Res (Gann), 76: 828-834, 1985.

15. Okamura, T., Fukushima, S., Inoue, K., Ito, N., Ueda, K., Ohtaguro, K.: Sequential studies of rat urinary bladder epithelial lesions induced by ifosfamide (Z4942). J Urol, 134: 778-781, 1985.

16. Tsuda, H., Moore, MA., Asamoto, M., Satoh, K., Tsuchida, S., Sato, K., Ichihara, A., Ito, N.: Comparison of the various forms of glutathione S-transferase with glucose-6-phosphate dehydrogenase and γ-glutamyltranspeptidase as markers of preneoplastic and neoplastic lesions in rat kidney induced by N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res (Gann), 76: 919-929, 1985.

17. Tatematsu, M., Mera, Y., Ito, N., Satoh, K., Sato, K.: Relative merits of immunohistochemical demonstrations of placental, A, B and C forms of glutathione S-transferase and histochemical demonstration of γ-glutamyl transferase as markers of altered foci during liver carcinogenesis in rats. Carcinogenesis, 6: 1621-1626, 1985.

18. Shirai, T., Masuda, A., Fukushima, S., Hosoda, K., Ito, N.: Effects of sodium L-ascorbate and related compounds on rat stomach carcinogenesis initiated by N-methyl-N’-nitro-N-nitrosoguanidine. Cancer Lett, 29: 283-288, 1985.

19. Kishikawa, H., Mizuno, T., Takagi, I., Yamakawa, Y., Shimozato, T., Honda, K., Tatematsu, M.: Nonfunctioning adrenocortical carcinoma in a young girl. Jpn J Surg, 15: 477-482, 1985.

20. Sumitomo, S., Tatemoto, Y., Fukui, S., Nakamura, T., Fukushima, S., Ito, N., Mori, M.: False positive reaction for carcinoembryonic antigen in paget cells. Virchows Arch [Cell Pathol], 49: 395-399, 1985.

21. Ogiso, T., Tatematsu, M., Tamano, S., Tsuda, H., Ito, N.: Comparative effects of carcinogens on the induction of placental glutathione S-transferase-positive liver nodules in a short-term assay and of hepatocellular carcinomas in a long-term assay. Toxicol Pathol, 13: 257-265, 1985.

22. Fukushima, S., Ito, N.: Papilloma, Forestomach, Rat. In: Jones, TC., Mohr, U., Hunt, RD. (eds.) Digestive System, pp289-292. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo, 1985.

23. Fukushima, S., Ito, N.: Squamous Cell Carcinoma, Forestomach, Rat. In: Jones, TC., Mohr, U., Hunt, RD. (eds.) Digestive System, pp292-295. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo, 1985.

24. Tatematsu, M., Ito, N.: Placental type of glutathione-S-transferase as a new marker for liver carcinogenesis. In: Jones, TC., Konishi, Y., Mohr, U. (eds.) The Liver, Salivary Glands, and Exocrine Pancreas of Laboratory Animals, Vol.28, pp145. Exp Pathol, 1985.

25. Moore, MA., Ito, N.: Comparative aspects of propyl nitrosamine carcinogenesis in Syrian golden hamsters. In: Jones, TC., Konishi, Y., Mohr, U. (eds.) The Liver, Salivary Glands, and Exocrine Pancreas of Laboratory Animals, Vol.28, pp145-146. Exp Pathol, 1985.

1. Tatematsu, M., Lurie, AG., Rippey, RM., Conran, PB., Arai, M., Fukushima, S., Ito, N.: Possible mechanistic roles of anatomical and functional vascular changes in rat urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res, 44: 278-284, 1984.

2. Ito, N., Moore, MA., Bannasch, P.: Modification of the development of N-nitrosomorpholine-induced hepatic lesions by 2-acetylaminofluorene, phenobarbital and 4,4′-diaminodiphenylmethane: a sequential histological and histochemical analysis. Carcinogenesis, 5: 335-342, 1984.

3. Furihata, C., Tatematsu, M., Miki, K., Katsuyama, T., Sudo, K., Miyagi, N., Kubota, T., Jin, SS., Kodama, K., Ito, N., Konishi, Y., Suzuki, K., Matsushima, T.: Gastric- and intestinal-type properties of human gastric cancers transplanted into nude mice. Cancer Res, 44: 727-733, 1984.

4. Shirai, T., Arai, M., Sakata, T., Fukushima, S., Ito, N.: Primary carcinomas of urinary bladder diverticula. Acta Pathol Jpn, 34: 417-424, 1984.

5. Tsuda, H., Nakanishi, K., Hatano, A., Okumura, M., Seki, K.: Summational effect of three different hepatopromoters in rats after initiation with diethylnitrosamine. Nagoya Med J, 28: 171-182, 1984.

6. Shirai, T., Ohshima, M., Masuda, A., Tamano, S., Ito, N.: Promotion of 2-(ethylnitrosamino)- ethanol-induced renal carcinogenesis in rats by nephrotoxic compounds: Positive responses with folic acid, basic lead acetate, and N-(3,5-dichlorophenyl)succinimide but not with 2,3-dibromo-1-propanol phosphate. J Natl Cancer Inst, 72: 477-482, 1984.

7. Tsuda, H., Sakata, T., Masui, T., Imaida, K., Ito, N.: Modifying effects of butylated hydroxyanisole, ethoxyquin and acetaminophen on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine. Carcinogenesis, 5: 525-531, 1984.

8. Sato, K., Kitahara, A., Satoh, K., Ishikawa, T., Tatematsu, M., Ito, N.: The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis. Gann, 75: 199-202, 1984.

9. Yanagi, S., Tsuda, H., Sakamoto, M., Fuse, E., Ito, N.: Effects of margarine on hepatocarcinogenesis by N,N’-2,7-fluorenylenebisacetamide in mice. Oncology, 41: 101-105, 1984.

10. Sato, K., Kitahara, A., Yin, Z., Waragai, F., Nishimura, K., Hatayama, I., Ebina, T., Yamazaki, T., Tsuda, H., Ito, N.: Induction by butylated hydroxyanisole of specific molecular forms of glutathione S-transferase and UDP-glucuronyltransferase and inhibition of development of γ-glutamyl transpeptidase-positive foci in rat liver. Carcinogenesis, 5: 473-477, 1984.

11. Shirai, T., Fukushima, S., Ohshima, M., Masuda, A., Ito, N.: Effects of butylated hydroxyanisole, butylated hydroxytoluene, and NaCl on gastric carcinogenesis initiated with N-methyl-N’-nitro-N-nitrosoguanidine in F344 rats. J Natl Cancer Inst, 72: 1189-1198, 1984.

12. Ito, N., Hirose, M., Kurata, Y., Ikawa, E., Mera, Y., Fukushima, S.: Induction of forestomach hyperplasia by crude butylated hydroxyanisole, a mixture of 3-tert and 2-tert isomers, in syrian golden hamsters is due to 3-tert-butylated hydroxyanisole. Gann, 75: 471-474, 1984.

13. Shirai, T., Kurata, Y., Fukushima, S., Ito, N.: Dose-related induction of lung, thyroid and kidney tumors by N-bis(2-hydroxypropyl)nitrosamine given orally to F344 rats. Gann, 75: 502-507, 1984.

14. Fukushima, S., Kurata, Y., Shibata, MA., Ikawa, E., Ito, N.: Promotion by ascorbic acid, sodium erythorbate and ethoxyquin of neoplastic lesions in rats initiated with N-butyl-N-(4-hydroxybutyl) nitrosamine. Cancer Lett, 23: 29-37, 1984.

15. Kitahara, A., Satoh, K., Nishimura, K., Ishikawa, T., Ruike, K., Sato, K., Tsuda, H., Ito, N.: Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis. Cancer Res, 44: 2698-2703, 1984.

16. Miyata, Y., Fukushima, S., Imaida, K., Ito, N.: Promoting effects of unilateral ureteric ligation on two-stage urinary bladder carcinogenesis in rats. Cancer Lett, 23: 265-272, 1984.

17. Tsuda, H., Sakata, T., Shirai, T., Kurata, Y., Tamano, S., Ito, N.: Modification of N-methyl-N-nitrosourea initiated carcinogenesis in the rat by subsequent treatment with antioxidants, phenobarbital and ethinyl estradiol. Cancer Lett, 24: 19-27, 1984.

18. Ito, N., Shirai, T., Fukushima, S., Hirose, M.: Dose-response study of urinary bladder carcinogenesis in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine. J Cancer Res Clin Oncol, 108: 169-173, 1984.

19. Sato, A., Nakajima, T., Koyama, Y., Shirai, T., Ito, N.: Dietary carbohydrate level as a modifying factor of 3′-methyl-4-dimethylaminoazobenzene liver carcinogenesis in rats. Gann, 75: 665-671, 1984.

20. Tsuda, H., Fukushima, S., Imaida, K., Sakata, T., Ito, N.: Modification of carcinogenesis by antioxidants and other compounds. Acta Pharmacol Toxicol, 55: 125-143, 1984.

21. Tsuda, H., Tamano, S., Imaida, K., Ohshima, M., Kitahori, Y., Ito, N.: Three-dimensional observations by scanning electron microscopy on the blood supply and organization of vasculature during hepatocarcinogenesis in rats. Acta Pathol Jpn, 34: 957-970, 1984.

22. Hagiwara, A., Fukushima, S., Kitaori, M., Shibata, M., Ito, N.: Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 75: 763-768, 1984.

23. Imaida, K., Fukushima, S., Shirai, T., Masui, T., Ogiso, T., Ito, N.: Promoting activities of butylated hydroxyanisole, butylated hydroxytoluene and sodium L-ascorbate on forestomach and urinary bladder carcinogenesis initiated with methylnitrosourea in F344 male rats. Gann, 75: 769-775, 1984.

24. Hagiwara, A., Shibata, M., Hirose, M., Fukushima, S., Ito, N.: Long-term toxicity and carcinogenicity study of sodium o-phenylphenate in B6C3F1 mice. Fd Chem Toxicol, 22: 809-814, 1984.

25. Tsuda, H., Takano, T., Shirai, T., Suzuki, M., Baba, S., Ito, N.: Comparative light and scanning electron microscopic observations of nasal cavity carcinogenesis in rats treated with 1,4-dinitrosopiperazine. J Cancer Res Clin Oncol, 108: 186-191, 1984.

26. Fukushima, S., Tsuda, H., Shirai, T., Nakakita, T., Sawaguchi, K., Takahashi, M.: An autopsy case of holoprosencephaly with cyclopia. Nagoya Med J, 29: 1-5, 1984.

27. Ito, N., Ogiso, T., Fukushima, S., Shibata, M., Hagiwara, A.: Carcinogenicity of captafol in B6C3F1 mice. Gann, 75: 853-865, 1984.

28. Tsuda, H., Masui, T., Imaida, K., Fukushima, S., Ito, N.: Promotive effect of primary and secondary bile acids on the induction of γ-glutamyl transpeptidase-positive liver cell foci as a possible endogenous factor for hepatocarcinogenesis in rats. Gann, 75: 871-875, 1984.

29. Tsuda, H., Hasegawa, R., Imaida, K., Masui, T., Moore, MA., Ito, N.: Modifying potential of thirty-one chemicals on the short-term development of γ-glutamyl transpeptidase-positive foci in diethylnitrosamine-initiated rat liver. Gann, 75: 876-883, 1984.

30. Shirai, T., Masuda, A., Hirose, M., Ikawa, E., Ito, N.: Enhancement of N-bis(2- hydroxypropyl)nitrosamine-initiated lung tumor development in rats by bleomycin and N-methyl-N-nitrosourethane. Cancer Lett, 25: 25-31, 1984.

31. Ohtani, M., Fukushima, S., Okamura, T., Sakata, T., Ito, N., Koiso, K., Niijima, T.: Effects of intravesical instillation of antitumor chemotherapeutic agents on bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer, 54: 1525-1529, 1984.

32. Moore, MA., Tsuda, H., Ogiso, T., Mera, Y., Ito, N.: Enhancement of phenotypic instability by α-difluoromethylornithine and butylated hydroxyanisole in rapidly induced rat liver lesions. Cancer Lett, 25: 145-151, 1984.

33. Sakata, T., Shirai, T., Fukushima, S., Hasegawa, R., Ito, N.: Summation and synergism in the promotion of urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine in F344 rats. Gann, 75: 950-956, 1984.

34. Tatematsu, M., Katsuyama, T., Furihata, C., Tsuda, H., Ito, N.: Stable intestinal phenotypic expression of gastric and small intestinal tumor cells induced by N-methyl- N’-nitro-N-nitrosoguanidine or methylnitrosourea in rats. Gann, 75: 957-965, 1984.

35. Yanagi, S., Tsuda, H., Sakamoto, M., Ninomiya, Y., Ito, N.: Evaluation of a histologic classification of mouse liver tumors based on pyruvate kinase isozymes and status of host lipids. J Natl Cancer Inst, 73: 1311-1317, 1984.

36. Fukushima, S., Hagiwara, A., Ogiso, T., Shibata, MA., Kurata, Y., Ito, N.: Spontaneous tumors in F344/DuCrj rats. Nagoya Med J, 29: 163-172, 1984.

37. Ito, N., Fukushima, S., Tsuda, H., Shirai, T., Tatematsu, M., Imaida, K.: Modification of chemical carcinogenesis by antioxidants. In: Fujiki, H. et al (eds.) Cellular Interactions by Environmental Tumor Promoters, pp381-389. Japan Sci Soc Press,Tokyo/VNU Science Press, Utrecht, 1984.

38. Ito, N., Fukushima, S., Shirai, T., Hagiwara, A., Imaida, K.: Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis. In: Borzsonyi, K. et al (eds.) Models, Mechanisms and Etiology of Tumour Promotion, IARC Scientific Publications No.56, pp399-407. International Agency for Research on Cancer, Lyon, 1984.

1. Fukushima, S., Hagiwara, A., Ogiso, T., Shibata, M., Ito, N.: Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-n-butyl-(4-hydroxybutyl)amine. Fd Chem Toxicol, 21: 59-68, 1983.

2. Hotta, K., Yamamoto, Y., Imaida, K., Oshima, M., Fukushima, S., Ito, N.: Membrance potential of rat urinary bladder epithelial cells. Jpn J Physiol, 33: 139-143, 1983.

3. Ito, N., Fukushima, S., Shirai, T., Nakanishi, K., Hasegawa, R., Imaida, K.: Modifying factors in urinary bladder carcinogenesis. Environ Health Perspect, 49: 217-222, 1983.

4. Fukushima, S., Arai, M., Nakanowatari, J., Hibino, T., Okuda, M., Ito, N.: Differences in susceptibility to sodium saccharin among various strains of rats and other animal species. Gann, 74: 8-20, 1983.

5. Shirai, T., Nakanowatari, J., Kurata, Y., Fukushima, S., Ito, N.: Different dose-response relationships in the induction of different types of colonic tumors in Wistar rats by 1,2-dimethylhydrazine. Gann, 74: 21-27, 1983.

6. Takahashi, M., Kokubo, T., Furukawa, F., Kurokawa, Y., Tatematsu, M., Hayashi, Y.: Effect of high salt diet on rat gastric carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine. Gann, 74: 28-34, 1983.

7. Ito, N., Fukushima, S., Hagiwara, A., Shibata, M., Ogiso, T.: Carcinogenicity of butylated hydroxyanisole in F344 rats. J Natl Cancer Inst, 70: 343-352, 1983.

8. Tatematsu, M., Furihata, C., Katsuyama, T., Hasegawa, R., Nakanowatari, J., Saito, D., Takahashi, M., Matsushima, T., Ito, N.: Independent induction of intestinal metaplasia and gastric cancer in rats treated with N-methyl-N’-nitro-N-nitrosoguanidine. Cancer Res, 43: 1335-1341, 1983.

9. Tatematsu, M., Hasegawa, R., Imaida, K., Tsuda, H., Ito, N.: Survey of various chemicals for initiating and promoting activities in a short-term in vivo system based on generation of hyperplastic liver nodules in rats. Carcinogenesis, 4: 381-386, 1983.

10. Imaida, K., Ishihara, Y., Nishio, O., Nakanishi, K., Ito, N.: Carcinogenicity and toxicity tests on p-phenylenediamine in F344 rats. Toxicol Lett, 16: 259-269, 1983.

11. Tsuda, H., Sakata, T., Tamano, S., Okumura, M., Ito, N.: Sequential observations on the appearance of neoplastic lesions in the liver and kidney after treatment with N- ethyl-N-hydroxyethylnitrosamine followed by partial hepatectomy and unilateral nephrectomy. Carcinogenesis, 4: 523-528, 1983.

12. Imaida, K., Oshima, M., Fukushima, S., Ito, N., Hotta, K.: Membrane potentials of urinary bladder epithelium in F344 rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine or sodium saccharin. Carcinogenesis, 4: 659-661, 1983.

13. Ito, N., Fukushima, S., Shirai, T., Nakanishi, K.: Effects of promoters on N-butyl-N- (4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. Environ Health Perspect, 50: 61-69, 1983.

14. Ito, N., Tsuda, H., Hasegawa, R., Imaida, K.: Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver. Environ Health Perspect, 50: 131-138, 1983.

15. Imaida, K., Fukushima, S., Shirai, T., Ohtani, M., Nakanishi, K., Ito, N.: Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of γ-glutamyl transpeptidase-positive foci development in the liver of rats. Carcinogenesis, 4: 895-899, 1983.

16. Tsuda, H., Fukushima, S., Imaida, K., Kurata, Y., Ito, N.: Organ-specific promoting effect of phenobarbital and saccharin in induction of thyroid, liver, and urinary bladder tumors in rats after initiation with N-nitrosomethylurea. Cancer Res, 43: 3292-3296, 1983.

17. Ito, N., Fukushima, S., Imaida, K., Sakata, T., Masui, T.: Induction of papilloma in the forestomach of hamsters by butylated hydroxyanisole. Gann, 74: 459-461, 1983.

18. Ito, N., Tsuda, H., Sakata, T., Hasegawa, R., Tamano, S.: Inhibitory effect of butylated hydroxyanisole and ethoxyquin on the induction of neoplastic lesions in rat liver after an initial treatment with N-ethyl-N-hydroxyethylnitrosamine. Gann, 74: 466-468, 1983.

19. Tsuda, H., Miyata, Y., Hatano, A., Inui, M., Ito, N.: Effects of dietary lithocholic and deoxycholic acids on rat liver. Nagoya Med J, 28: 65-70, 1983.

20. Fukushima, S., Imaida, K., Sakata, T., Okamura, T., Shibata, MA., Ito, N.: Promoting effects of sodium L-ascorbate on two-stage urinary bladder carcinogenesis in rats. Cancer Res., 43: 4454-4457, 1983.

21. Hayashi, M., Tsuda, H., Ito, N.: Histopathological classification of spontaneous hyperplastic liver nodules in slaughtered swine. J Comp Pathol, 93: 603-612, 1983.

22. Tamano, S., Tsuda, H., Fukushima, S., Masui, T., Hosoda, K., Ito, N.: Dose and sex dependent effects of 2-acetylaminofluorene, 3′-methyl-4-dimethylaminoazobenzene and DL-ethionine in induction of γ-glutamyl transpeptidase-positive liver cell foci in rats. Cancer Lett, 20: 313-321, 1983.

23. Fukushima, S., Kurata, Y., Shibata, MA., Ikawa, E., Ito, N.: Promoting effect of sodium o-phenylphenate and o-phenylphenol on two-stage urinary bladder carcinogenesis in rats. Gann, 74: 625-632, 1983.

24. Hirose, M., Fukushima, S., Sakata, T., Inui, M., Ito, N.: Effect of quercetin on two-stage carcinogenesis of the rat urinary bladder. Cancer Lett, 21: 23-27, 1983.

25. Lurie, AG., Tatematsu, M., Nakatsuka, T., Rippey, RM., Ito, N.: Anatomical and functional vascular changes in hamster cheek pouch during carcinogenesis induced by 7,12-dimethylbenz(a)anthracene. Cancer Res, 43: 5986-5994, 1983.

26. Hagiwara, A., Shibata, M., Kurata, Y., Seki, K., Fukushima, S., Ito, N.: Long-term toxicity and carcinogenicity test of ammonia-process caramel colouring given to B6C3F1 mice in the drinking-water. Fd Chem Toxicol, 21: 701-706, 1983.

27. Ohtani, M., Fukushima, S., Ito, N., Koiso, K., Niijima, T.: Effects of intravesical instillation of antitumor drugs on the induction of preneoplastic bladder lesions in rats. Cancer Chemother Pharmacol, 11 (Suppl): S64-S66, 1983.

28. Tsuda, H.: Goiter, adenoma, and carcinoma of the thyroid induced by amitrole and ethylenethiourea, rat. In: Jones, TC., Moher, U., Hunt, RD.(eds.) Endocrine System, pp204-211. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo, 1983.

29. Sato, K., Kitahara, A., Yin, Z., Ebina, T., Satoh, K., Tsuda, H., Ito, N., Dempo, K.: Molecular forms of glutathione S-transferase and UDP-glucuronyltransferase as hepatic preneoplastic marker enzymes. In: Alpert, E., Hirai, H. (eds.) Annals of the New York Academy of Sciences, Vol.417, pp213-223. ANN N.Y. Acad Sci, New York, 1983.

1. Tatematsu, M., Katsuyama, T., Nakanowatari, J., Hasegawa, R., Imaida, K., Fukushima, S., Ito, N.: Region-specific patterns of mucin reaction demonstrated by paradoxical concanavalin A-staining in normal colonic epithelium and in colorectal cancers induced in rats by 1,2-dimethylhydrazine. Gann, 73: 77-84, 1982.

2. Hasegawa, R., Tsuda, H., Ogiso, T., Ohshima, M., Ito, N.: Initiating activities of pyrolysis products of L-lysine and soybean globulin assessed in terms of the induction of γ-glutamyl transpeptidase-positive foci in rat liver. Gann, 73: 158-159, 1982.

3. Fukushima, S., Murasaki, G., Hirose, M., Nakanishi, K., Hasegawa, R., Ito, N.: Histopathological analysis of preneoplastic changes during N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder carcinogenesis in rats. Acta Pathol Jpn, 32: 243-250, 1982.

4. Nakanishi, K., Kurata, Y., Ohshima, M., Fukushima, S., Ito, N.: Carcinogenicity of phenacetin: long-term feeding study in B6C3F1 mice. Int J Cancer, 29: 439-444, 1982.

5. Nakanishi, K., Fukushima, S., Hagiwara, A., Tamano, S., Ito, N.: Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats. J Natl Cancer Inst, 68: 497-500, 1982.

6. Yin, Z., Sato, K., Tsuda, H., Ito, N.: Changes in activities of uridine diphosphate- glucuronyltransferases during chemical hepatocarcinogenesis. Gann, 73: 239-248, 1982.

7. Hasegawa, R., Tatematsu, M., Tsuda, H., Shirai, T., Hagiwara, A., Ito, N.: Induction of hyperplastic liver nodules in hepatectomized rats treated with 3′-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide. Gann, 73: 264-269, 1982.

8. Ito, N., Hagiwara, A., Shibata, M., Ogiso, T., Fukushima, S.: Induction of squamous cell carcinoma in the forestomach of F344 rats treated with butylated hydroxyanisole. Gann, 73: 332-334, 1982.

9. Hasegawa, R., Tatematsu, M., Imaida, K., Murasaki, G., Ito, N., Watanabe, I., Nakazato, M.: Neuroblastoma in situ. Acta Pathol Jpn, 32: 537-546, 1982.

10. Hirose, M., Takahashi, M., Fukushima, S., Shibata, M., Ito, N.: Chronic effects of 1,3-di(4-sulfamoylphenyl)triazene on male ICR mice. Nagoya Med J, 26: 173-177, 1982.

11. Cameron, RG., Imaida, K., Tsuda, H., Ito, N.: Promotive effects of steroids and bile acids on hepatocarcinogenesis initiated by diethylnitrosamine. Cancer Res, 42: 2426-2428, 1982.

12. Imaida, K., Hirose, M., Ogisa, T., Kurata, Y., Ito, N.: Quantitative analysis of initiating and promoting activities of five mycotoxins in liver carcinogenesis in rats. Cancer Lett, 16: 137-143, 1982.

13. Fukushima, S., Hirose, M., Okuda, M., Nakanowatari, J., Hatano, A., Ito, N.: Effect of partial cystectomy on the induction of pre-neoplastic lesions in rat bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by bladder carcinogens and promoters. Urol Res, 10: 115-118, 1982.

14. Takano, T., Shirai, T., Ogiso, T., Tsuda, H., Baba, S., Ito, N.: Sequential changes in tumor development induced by 1,4-dinitrosopiperazine in the nasal cavity of F344 rats. Cancer Res, 42: 4236-4240, 1982.

15. Hasegawa, R., Tsuda, H., Nakanishi, K., Tatematsu, M., Ito, N.: Route-dependent, organ-specific effects of carcinogens on induction of hyperplastic liver nodules in rats. Toxicol Lett, 14: 229-235, 1982.

16. Shirai, T., Hagiwara, A., Kurata, Y., Shibata, M., Fukushima, S., Ito, N.: Lack of carcinogenicity of butylated hydroxytoluene on long-term administraiton to B6C3F1 mice. Fd Chem Toxicol, 20: 861-865, 1982.

17. Ogiso, T., Arai, Y., Fukushima, S., Nishizuka, Y., Ito, N.: Enhancing effect of diethylstilbestrol on urinary bladder carcinogenesis in neonatally castrated male rats. Gann, 73: 862-869, 1982.

18. Shirai, T., Imaida, K., Fukushima, S., Hasegawa, R., Tatematsu, M., Ito, N.: Effects of NaCl, Tween 60 and a low dose of N-ethyl-N’-nitro-N-nitrosoguanidine on gastric carcinogenesis of rat given a single dose of N-methyl-N’-nitro-N-nitrosoguanidine. Carcinogenesis, 3: 1419-1422, 1982.

19. Tsuda, H., Hagiwara, A., Shibata, M., Ohshima, M., Ito, N.：Carcinogenic effect of carbazole in the liver of (C57BL/6N x C3H/HeN)F1 mice. J Natl Cancer Inst, 69: 1383-1389, 1982.

20. Yanagi, S., Sakamoto, M., Tsuda, H., Tatematsu, M., Ito, N., Yamamoto, N., Furuyama, S.: Effect of safflower oil and safflower margarine on hepatic tumorigenesis by N,N’-2,7-fluorenylenebisacetamide. J Nara Med Assoc, 33: 545-548, 1982.

21. Hasegawa, R., Imaida, K., Fukushima, S., Tsuda, H., Ito, N., Masuko, K.: Effect of hemodialysis on amyloid deposition (18 Autopsy Cases). Nagoya Med J, 27: 277-286, 1982.

22. Ito, N., Tsuda, H., Hasegawa, R., Imaida, K.: Sequential observation of pathomorphologic alterations in preneoplastic lesions during the promoting stage of hepatocarcinogenesis and the development of short-term test system for hepatopromoters and hepatocarcinogens. Toxicol Pathol, 10: 37-49, 1982.

23. Ito, N., Tatematsu, M., Nakanishi, K., Tsuda, H.: Analysis of the effect of promoting agents on liver and urinary bladder carcinogenesis in rats. In: Hecker, E., Fusenig, NE., Kunz, W., Marks, F., Thielmann, HW.(eds.) Carcinogenesis. A Comprehensive Survey, Vol.7, pp133-137. Raven Press, New York, 1982.

24. Ito, N., Fukushima, S., Tsuda, H., Shirai, T., Arai, M.: Induction of preneoplastic and neoplastic lesions in rats treated N-nitroso compounds. In: Bartsch, H., O’Neill, IK., Castegnaro, M., Okada, M. (eds.) N-nitroso-compounds: Occurrence and Biological Effects, IARC Scientific Publication Vol.41, pp597-601. International Agency for Research on Cancer, Lyon, 1982.

25. Ito, N., Nakanishi, K., Fukushima, S., Tsuda, H., Shirai, T.: Promoting and inhibiting factors on liver and urinary bladder carcinogenesis in rats. In: Pani, P., Feo, F., Columbano, A. (eds.) Recent Trends in Chemical Carcinogenesis, Vol.1, pp199-213. ESA, Cagliari, 1982.

1. Cameron, R., Imaida, K., Ito, N.: Promotive effects of ethinyl estradiol in hepatocarcinogenesis initiated by diethylnitrosamine in male rats. Gann, 72: 339-340, 1981.

2. Hirose, M., Shibata, M., Hagiwara, A., Imaida, K., Ito, N.: Chronic toxicity of butylated hydroxytoluene in Wistar rats. Fd Cosmet Toxicol, 19: 147-151, 1981.

3. Tatematsu, M., Imaida, K., Ito, N., Togari, H., Suzuki, Y., Ogiu, T.: Sandhoff disease. Acta Pathol Jpn, 31: 503-512, 1981.

4. Tatematsu, M., Imaida, K., Fukushima, S., Arai, M., Mizutani, M., Ito, N.: Cytopathological effect of partial cystectomy of rats. Acta Pathol Jpn, 31: 535-543, 1981.

5. Ito, N., Hirose, M., Shirai, T., Tsuda, H., Nakanishi, K., Fukushima, S.: Lesions of the urinary bladder epithelium in 125 autopsy cases. Acta Pathol Jpn, 31: 545-557, 1981.

6. Cameron, R., Imaida, K., Ito, N.: Promotive effects of deoxycholic acid on hepatocarcinogenesis initiated by diethylnitrosamine in male rats. Gann, 72: 635-636, 1981.

7. Takahashi, M., Shirai, T., Fukushima, S., Ito, N., Kokubo, T., Furukawa, F., Kurata, Y.: Ulcer formation and associated tumor production in multiple sites within the stomach and duodenum of rats treated with N-methyl-N’-nitro-N-nitrosoguanidine. J Natl Cancer Inst, 67: 473-479, 1981.

8. Hirose, M., Imaida, K., Ito, H., Hayashi, M., Ishihara, Y., Ito, N.: Effects of chloroform and dimethylnitrosamine on renal carcinogenesis in unilaterally nephrectomized rats fed formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide. Carcinogenesis, 2: 703-708, 1981.

9. Tamano, S., Tsuda, H., Tatematsu, M., Hasegawa, R., Imaida, K., Ito, N.: Induction of γ-glutamyl transpeptidase positive foci in rat liver by pyrolysis products of amino acids. Gann, 72: 747-753, 1981.

10. Fukushima, S., Ishihara, Y., Nishio, O., Ogiso, T., Shirai, T., Ito, N.: Carcinogenicities of quinoline derivatives in F344 rats. Cancer Lett, 14: 115-123, 1981.

11. Suganuma, T., Katsuyama, T., Tsukahara, M., Tatematsu, M., Sakakura, Y., Murata, F.: Comparative histochemical study of alimentary tracts with special reference to the mucous neck cells of the stomach. Am J Anatomy, 161: 219-238, 1981.

12. Fukushima, S., Hirose, M., Hagiwara, A., Hasegawa, R., Ito, N.: Inhibitory effect of 4,4’-diaminodiphenylmethane on liver, kidney and bladder carcinogenesis in rats ingesting N-ethyl-N-hydroxyethylnitrosamine or N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 2: 1033-1037, 1981.

13. Sato, K., Hatayama, I., Hoshino, K., Imai, F., Tsuchida, S., Sato, T., Nishimura, K., Tatematsu, M., Ito, N.: Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens. Cancer Res, 41: 4147-4153, 1981.

14. Imaida, K., Shirai, T., Tatematsu, M., Takano, T., Ito, N.: Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis. Cancer Lett, 14: 279-283, 1981.

15. Hirose, M., Shirai, T., Tsuda, H., Fukushima, S., Ogiso, T., Ito, N.: Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally. Carcinogenesis, 2: 1299-1302, 1981.

16. Ito, N.: In vivo carcinogenesis of 4-nitroquinoline 1-oxide and related compounds. In: Sugimura, T. (ed.) Carcinogenesis, Vol. 6, pp117-153. Raven Press, New York, 1981.

1. Tada, M., Takahashi, K., Kawazoe, Y., Ito, N.: Binding of quinoline to nucleic acid in a subcellular microsomal system. Chem Biol Interact, 29: 257-266, 1980.

2. Miyata, Y., Hagiwara, A., Nakatsuka, T., Murasaki, G., Arai, M., Ito, N.: Effects of caffeine and saccharin on DNA in the bladder epithelium of rats treated with N-butyl-N-(3-carboxypropyl)nitrosamine. Chem Biol Interact, 29: 291-302, 1980.

3. Hayashi, M., Ishihara, Y., Nishio, O., Tatematsu, M., Makino, M., Asai, T.: Histopathological observations of spontaneous tumors in slaughtered-animals (73 cases). Nagoya Med J, 24: 163-176, 1980.

4. Arai, M., Ito, H., Nakanishi, K., Hasegawa, R., Yoshimura, T., Murasaki, G., Ito, N.: Ultrastructural study of changes of the basement membrane and capillaries of the urinary bladder in rats induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Nagoya Med J, 24: 177-187, 1980.

5. Tatematsu, M., Saito, D., Furihata, C., Miyata, Y., Nakatsuka, T., Ito, N., Sugimura, T.: Initial DNA damage and heritable permanent change in pepsinogen isoenzyme pattern in the pyloric mucosae of rats after short-term administration of N-methyl-N’-nitro-N-nitrosoguanidine. J Natl Cancer Inst, 64: 775-781, 1980.

6. Tatematsu, M., Katsuyama, T., Fukushima, S., Takahashi, M., Shirai, T., Ito, N., Nasu, T.: Mucin histochemistry by paradoxical concanavalin A staining in experimental gastric cancers induced in Wistar rats by N-methyl-N’-nitro-N-nitrosoguanidine or 4-nitroquinoline 1-oxide. J Natl Cancer Inst, 64: 835-843, 1980.

7. Murasaki, G., Miyata, Y., Babaya, K., Arai, M., Fukushima, S., Ito, N.: Inhibitory effect of an aromatic retinoic acid analog on urinary bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 71: 333-340, 1980.

8. Miyata, Y., Nakatsuka, T., Arai, M., Murasaki, G., Nakanishi, K., Ito, N.: Inhibition by an aromatic retinoid of DNA damage induced by the bladder carcinogen N-butyl-N-(3-carboxypropyl)nitrosamine. Gann, 71: 341-348, 1980.

9. Ito, N., Tatematsu, M., Imaida, K., Hasegawa, R., Murasaki, G.: Effects of various promoters on the induction of hyperplastic nodules in rat liver. Gann, 71: 415-416, 1980.

10. Hagiwara, A., Arai, M., Hirose, M., Nakanowatari, J., Tsuda, H., Ito, N.: Chronic effects of norharman in rats treated with aniline. Toxicol Lett, 6: 71-75, 1980.

11. Cohen, SM., Tatematsu, M., Shinohara, Y., Nakanishi, K., Ito, N.: Neovascularization in rats during urinary bladder carcinogenesis induced by N-[4-(5-nitro-2-furyl)thiazolyl]formamide. J Natl Cancer Inst, 65: 145-148, 1980.

12. Nakanishi, K., Hirose, M., Ogiso, T., Hasegawa, R., Arai, M., Ito, N.: Effect of sodium saccharin and caffeine on the urinary bladder of rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 71: 490-500, 1980.

13. Takano, T., Tatematsu, M., Hasegawa, R., Imaida, K., Ito, N.: Dose-response relationship for the promoting effect of phenobarbital on the induction of liver hyperplastic nodules in rats exposed to 2-fluorenylacetamide and carbon tetrachloride. Gann, 71: 580-581, 1980.

14. Hirose, M., Murasaki, G., Imaida, K., Fukushima, S., Ito, N.: Effect of cyclophosphamide on rat urinary bladder epithelium treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 71: 729-732, 1980.

15. Hirose, M., Fukushima, S., Shibata, M., Ito, N.: Chronic effects of oral ethylenecyanohydrin on male rats and mice. Nagoya Med J, 25: 1-5, 1980.

16. Nakanishi, K., Hagiwara, A., Shibata, M., Imaida, K., Tatematsu, M., Ito, N.: Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. J Natl Cancer Inst, 65: 1005-1010, 1980.

17. Takahashi, M., Arai, M., Kokubo, T., Furukawa, F., Kurata, Y., Ito, N.: An ultrastructural study of precancerous and cancerous lesions of the pancreas in Syrian golden hamsters induced by N-nitrosobis(2-oxopropyl)amine. Gann, 71: 825-831, 1980.

18. Ito, N., Tatematsu, M., Nakanishi, K., Hasegawa, R., Takano, T., Imaida, K., Ogiso, T.: The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide. Gann, 71: 832-842, 1980.

19. Tatematsu, M., Takano, T., Hasegawa, R., Imaida, K., Nakanowatari, J., Ito, N.: A sequential quantitative study of the reversibility or irreversibility of liver hyperplastic nodules in rats exposed to hepatocarcinogens. Gann, 71: 843-855, 1980.

20. Ito, N., Nakanishi, K., Hagiwara, A., Shibata, M., Fukushima, S.: Induction of hyperplasic liver nodules by phenobarbital in rats initiated with N-butyl-N-(4- hydroxybutyl)nitrosamine. Gann, 71: 918-919, 1980.

1. Tatematsu, M., Murasaki, G., Nakanishi, K., Miyata, Y., Shinohara, Y., Ito, N.: Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals. Gann, 70: 125-130, 1979.

2. Murasaki, G., Miyata, Y., Shirai, T., Arai, M., Kawachi, T., Ito, N.: Effects of the co-mutagen norharman in rats. Toxicol Lett, 3: 157-161, 1979.

3. Fukushima, S., Shibata, M., Hibino, T., Yoshimura, T., Hirose, M., Ito, N.: Intrahepatic bile duct proliferation induced by 4,4’-diaminodiphenylmethane in rats. Toxicol Appl Pharmacol, 48: 145-155, 1979.

4. Shinohara, Y., Hasegawa, R., Ito, N., Kanayama, M., Kato, T., Wada, Y.: Tyrosinemia. Acta Pathol Jpn, 29: 615-622, 1979.

5. Arai, M., Aoki, Y., Nakanishi, K., Miyata, Y., Mori, T., Ito, N.: Long-term experiment of maximal non-carcinogenic dose of dimethylnitrosamine for carcinogenesis in rats. Gann, 70: 549-558, 1979.

6. Hirose, M., Maekawa, A., Kamiya, S., Odashima, S.: Carcinogenic effect of N-ethyl- and N-amyl-N-nitrosourethans on female Donryu rats. Gann, 70: 653-662, 1979.

7. Lurie, AG., Rippey, RM., Conran, PB., Tatematsu, M., Ito, N.: A technique for multiparametric analysis of hemodynamic changes in rat urinary bladder during carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 70: 717-718, 1979.

8. Tatematsu, M., Nakatsuka, T., Lurie, AG., Rippey, RM., Suzuki, M., Ito, N.: Neovascularization during hamster cheek pouch carcinogenesis induced by 7,12-dimethylbenz[a]anthracene. Gann, 70: 719-720, 1979.

9. Tsuchida, S., Hoshino, K., Sato, T., Ito, N., Sato, K.: Purification of γ-glutamyltranferases from rat hepatomas and hyperplastic hepatic nodules, and comparison with the enzyme from rat kidney. Cancer Res, 39: 4200-4205, 1979.

10. Tatematsu, M., Nakanishi, K., Murasaki, G., Miyata, Y., Hirose, M., Ito, N.: Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats. J Natl Cancer Inst, 63: 1411-1416, 1979.

11. Ito, N., Takahashi, M., Fukushima, S., Shirai, T., Tatematsu, M.: Factors which modify induction of experimental glandular gastric cancer in rats and mice. In: Pfeiffer, CJ.(ed.) Experimental Gastric Cancer. Etiology and Pathogenesis, pp277-301. Gerhard Witzstrock Publising House, Inc., New York, 1979.

12. Imai, F., Takaya, S., Hatayama, I., Sato, T., Ito, N., Sato, K.: Rat hyperplastic hepatic nodules and primary hepatomas retaining abnormally high pyruvate kinase L type activity. In: Colombo, JP., Frei, J., Greengard, O., Knox, WE. (eds.) Enzyme, Vol.24, pp313-321. S. Karger, Basel, 1979.

1. Tatematsu, M., Takahashi, M., Tsuda, H., Ogiso, T., Ito, N.: The administration of reserpine to rats for 75 weeks. Toxicol Lett, 1: 201-205, 1978.

2. Ito, N., Tatematsu, M., Hirose, M., Nakanishi, K., Murasaki, G.: Enhancing effect of chemicals on production of hyperplastic liver nodules induced by N-2-fluorenylacetamide in hepatectomized rats. Gann, 69: 143-144, 1978.

3. Shirai, T., Cohen, SM., Fukushima, S., Hananouchi, M., Ito, N.: Reversible papillary hyperplasia of the rat urinary bladder. Am J Pathol, 91: 33-48, 1978.

4. Hiasa, Y., Ito, N., Ohshima, M., Ohmori, T., Seki, A., Tatsumi, T., Yokoi, H., Iwata, C., Murata, Y., Ito, N.: Ultrastructure of an anaplastic giant-cell carcinoma found 8 years after operation of a papillary carcinoma of the thyroid. Acta Pathol Jpn, 28: 637-644, 1978.

5. Takahashi, M., Shirai, T., Fukushima, S., Hosoda, K., Yoshida, S., Ito, N.: Carcinogenicity of 8-nitroquinoline in Sprague-Dawley rats. Cancer Lett, 4: 265-270, 1978.

6. Shirai, T., Miyata, Y., Nakanishi, K., Murasaki, G., Ito, N.: Hepatocarcinogenicity of polychlorinated terphenyl (PCT) in ICR mice and its enhancement by hexachlorobenzene (HCB). Cancer Lett, 4: 271-275, 1978.

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17. Miyata, Y., Tsuda, H., Matayoshi-Miyasato, K., Fukushima, S., Murasaki, G., Ogiso, T., Ito, N.: Effect of vitamin A acetate on urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats. Gann, 69: 845-848, 1978.

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2. Nagao, M., Yahagi, T., Seino, Y., Sugimura, T., Ito, N.: Mutagenicities of quinoline and its derivatives. Mutation Res, 42: 335-342, 1977.

3. Tsuda, H., Miyata, Y., Murasaki, G., Kinoshita, H., Fukushima, S., Ito, N.: Synergistic effect of urinary bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine, N-[4-(5-nitro-2-furyl)-2-thiazolyl]- formamide, N-2-fluorenylacetamide, and 3,3′-dichlorobenzidine. Gann, 68: 183-192, 1977.

4. Tatematsu, M., Miyata, Y., Mizutani, M., Hananouchi, M., Hirose, M., Ito, N.: Summation effect of N-butyl-N-(4-hydroxybutyl)nitrosamine, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide, N-2-fluorenyl- acetamide, and 3,3′-dichlorobenzidine on urinary bladder carcinogenesis in rats. Gann, 68: 193-202, 1977.

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15. Fukushima, S., Hibino, T., Shibata, M., Tsuda, H., Shirai, T., Takahashi, M., Ito, N.: Effect of iodoacetamide or Tween 60 on methyl-nitrosocyanamide carcinogenesis in rat glandular and forestomach. Gann, 68: 813-818, 1977.

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